Improvement in Motor Skills, Attention, and Working Memory in Mild Cognitive Impairment and Alzheimer’s Disease Patients Using COSMA Cognitive App

Aikaterini Christogianni, Kartheka Bojan, Elizabeta Mukaetova-Ladinska, V. T. Sriramm, G. Murthy, Gopukumar Kumarpillai
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Abstract

There are a rapid growth of adults with cognitive impairments and an increasing need for cognitive stimulation and rehabilitation to delay cognitive deterioration. COSMA, a cognitive gaming app, was developed to assist cognitive stimulation in people with cognitive decline and dementia. Therefore, the study was conducted to investigate the effectiveness of COSMA in people with mild cognitive impairment (MCI) and early Alzheimer’s disease (AD). The study involved a treatment group who played COSMA at home and during laboratory visits for 28 days and a control group who played only during laboratory visits. Each group was measured on days 1–14–28, where recordings of playing COSMA and Cambridge Neuropsychological Test Automated Battery (CANTAB) tests were taken. The results showed that the MCI treatment group improved sensorimotor skills in 14 days, sustained attention, spatial planning, working and visual memory, and learning in 28 days. The AD treatment group improved in sustained attention in 14 and 28 days and showed a lower cognitive decline in working memory compared to the AD control group in 28 days. Both control groups did not show any level of improvement. Even though the progression of the MCI was faster than that of the early AD, the study showed inspired results of cognitive improvement in both groups. COSMA showed evidence that cognitive stimulation and rehabilitation are possible in MCI and AD and that it is an effective and efficient non-pharmacological therapeutic tool in these groups of patients.

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使用 COSMA 认知应用程序提高轻度认知障碍和阿尔茨海默病患者的运动技能、注意力和工作记忆能力
成人认知障碍患者数量迅速增长,越来越需要认知刺激和康复来延缓认知退化。COSMA是一款认知游戏应用,旨在帮助认知能力下降和痴呆症患者进行认知刺激。因此,本研究旨在探讨COSMA对轻度认知障碍(MCI)和早期阿尔茨海默病(AD)患者的疗效。在这项研究中,治疗组在28天的时间里在家和在实验室访问期间玩COSMA,而对照组只在实验室访问期间玩。每组在第1-14-28天进行测量,记录播放COSMA和剑桥神经心理测试自动电池(CANTAB)测试。结果显示,MCI治疗组在14天内改善了感觉运动技能,在28天内改善了持续注意力、空间规划、工作和视觉记忆以及学习能力。阿尔茨海默病治疗组在14天和28天的持续注意力方面有所改善,与阿尔茨海默病对照组相比,在28天的工作记忆方面表现出较低的认知衰退。两个对照组都没有表现出任何程度的改善。尽管轻度认知障碍的进展比早期阿尔茨海默病的进展要快,但研究显示,两组患者的认知能力都得到了令人鼓舞的改善。COSMA显示认知刺激和康复在轻度认知损伤和AD中是可能的,并且在这些患者群体中是一种有效和高效的非药物治疗工具。
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