Association between human blood metabolome and the risk of hypertension

IF 2.9 Q2 Biochemistry, Genetics and Molecular Biology BMC Genetics Pub Date : 2023-12-15 DOI:10.1186/s12863-023-01180-z
Nannan Dai, Yujuan Deng, Baishi Wang
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Abstract

Hypertension, commonly referred to as high blood pressure, is a chronic medical condition characterized by persistently elevated blood pressure levels. It is a prevalent global health issue, affecting a significant portion of the population worldwide. Hypertension is often asymptomatic, making it a silent but potentially dangerous condition if left untreated. Genetic instruments for 1,091 were from a recent comprehensive metabolome genome-wide association study (GWAS). Summary statistics of diastolic blood pressure (DBP) and systolic blood pressure (SBP) involving 757,601 sample size were analyzed. Two-sample Mendelian Randomization (MR) was conducted to assess causal effect of metabolites on DBP and SBP risk, and reverse MR analysis was performed to identify the DBP/SBP causal effect on blood metabolites. Twelve and twenty-two metabolites were identified to be associated with DBP and SBP, respectively. Sensitive analysis showed four metabolites had robustness association on BP. Reverse MR demonstrated DBP and SBP could decrease the tricosanoyl sphingomyelin (d18:1/23:0)* level and increase the 2-hydroxyhippurate (salicylurate) level in blood, respectively. Our findings reveal an association between blood metabolites and blood pressure (DBP and SBP), suggesting potential therapeutic targets for hypertension intervention.

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人体血液代谢组与高血压风险之间的关系
高血压俗称高血脂,是一种以血压持续升高为特征的慢性疾病。它是一个普遍的全球性健康问题,影响着全球相当一部分人口。高血压通常没有症状,因此如果不及时治疗,虽然无声无息,但却有潜在的危险。最近的一项综合性代谢组全基因组关联研究(GWAS)提供了 1,091 个基因工具。对涉及 757601 个样本量的舒张压(DBP)和收缩压(SBP)进行了汇总统计分析。通过双样本孟德尔随机化(MR)评估代谢物对 DBP 和 SBP 风险的因果效应,并通过反向 MR 分析确定 DBP/SBP 对血液代谢物的因果效应。结果发现,分别有 12 种和 22 种代谢物与 DBP 和 SBP 相关。敏感性分析表明,四种代谢物与血压有稳健的相关性。反向 MR 显示,DBP 和 SBP 可分别降低血液中三糖酰鞘磷脂(d18:1/23:0)*的水平和增加 2-羟基海波酸盐(水杨酸盐)的水平。我们的研究结果揭示了血液代谢物与血压(DBP 和 SBP)之间的关系,为高血压干预提供了潜在的治疗靶点。
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来源期刊
BMC Genetics
BMC Genetics 生物-遗传学
CiteScore
4.30
自引率
0.00%
发文量
77
审稿时长
4-8 weeks
期刊介绍: BMC Genetics is an open access, peer-reviewed journal that considers articles on all aspects of inheritance and variation in individuals and among populations.
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