A 28-day subacute oral toxicity study of Apis cerana (Fabricius) honey in Wistar rats

IF 0.7 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY international food research journal Pub Date : 2023-12-20 DOI:10.47836/ifrj.30.6.11
Hongju Du, Peng Zhang, Shan Zheng, Yanmin Nie, Wenjing Zhang, Ying Feng, Jun-yu Ning, Guojun Li, Shan Gao
{"title":"A 28-day subacute oral toxicity study of Apis cerana (Fabricius) honey in Wistar rats","authors":"Hongju Du, Peng Zhang, Shan Zheng, Yanmin Nie, Wenjing Zhang, Ying Feng, Jun-yu Ning, Guojun Li, Shan Gao","doi":"10.47836/ifrj.30.6.11","DOIUrl":null,"url":null,"abstract":"The use of honey as food and medicine is widespread, but insufficient data support that it is safe, especially when consumed in high doses. As a result, the present work aimed to investigate the potential toxicity using a repeated dose oral toxicity study. In the toxicity study, Wistar rats were divided into five groups, and orally administered with distilled water (control), 3, 6, 12, and 24 g/kg body weight (BW)/day of honey for 28 days in a row. Body weight, food consumption, clinical pathology, and histopathology were then examined. Significant suppression of body weight, food consumption, and body weight gain was observed at the dose of 24 g/kg BW in both sexes. Honey administration had no statistically significant effect on any of the haematological parameters. The clinical observations, blood coagulation and biochemical parameters, target organs, or histopathology did not reveal any additional nor other treatment-related adverse effects. Mild pathological changes in hepatic tissues were observed in the control, 12, or 24 g/kg BW dose groups, which were common spontaneous lesions unrelated to honey treatment. In the 24 g/kg BW group, one male rat showed non-specific reactions such as focal basophilic change of renal tubule cells, which were also regarded as spontaneous lesions. Based on these results, the no-observed-adverse-effect level (NOAEL) of honey in this repeat dose oral toxicity study was determined to be 12 g/kg BW in both sexes of Wistar rats.","PeriodicalId":13754,"journal":{"name":"international food research journal","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"international food research journal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.47836/ifrj.30.6.11","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The use of honey as food and medicine is widespread, but insufficient data support that it is safe, especially when consumed in high doses. As a result, the present work aimed to investigate the potential toxicity using a repeated dose oral toxicity study. In the toxicity study, Wistar rats were divided into five groups, and orally administered with distilled water (control), 3, 6, 12, and 24 g/kg body weight (BW)/day of honey for 28 days in a row. Body weight, food consumption, clinical pathology, and histopathology were then examined. Significant suppression of body weight, food consumption, and body weight gain was observed at the dose of 24 g/kg BW in both sexes. Honey administration had no statistically significant effect on any of the haematological parameters. The clinical observations, blood coagulation and biochemical parameters, target organs, or histopathology did not reveal any additional nor other treatment-related adverse effects. Mild pathological changes in hepatic tissues were observed in the control, 12, or 24 g/kg BW dose groups, which were common spontaneous lesions unrelated to honey treatment. In the 24 g/kg BW group, one male rat showed non-specific reactions such as focal basophilic change of renal tubule cells, which were also regarded as spontaneous lesions. Based on these results, the no-observed-adverse-effect level (NOAEL) of honey in this repeat dose oral toxicity study was determined to be 12 g/kg BW in both sexes of Wistar rats.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
陶瓷蜂(Fabricius)蜂蜜对 Wistar 大鼠为期 28 天的亚急性毒性口服研究
蜂蜜被广泛用作食品和药物,但没有足够的数据证明它是安全的,尤其是在大剂量食用时。因此,本研究旨在通过重复剂量口服毒性研究来调查蜂蜜的潜在毒性。在毒性研究中,Wistar 大鼠被分为五组,连续 28 天分别口服蒸馏水(对照组)、3、6、12 和 24 克/千克体重(BW)/天的蜂蜜。然后对体重、食量、临床病理学和组织病理学进行检查。在每公斤体重 24 克的剂量下,雌雄大黄蜂的体重、食量和体重增加均受到显著抑制。在统计学上,服用蜂蜜对任何血液学参数都没有显著影响。临床观察、血液凝固和生化参数、靶器官或组织病理学均未发现任何其他与治疗相关的不良反应。对照组、12 克/千克体重组和 24 克/千克体重组的肝组织出现了轻微的病理变化,这是常见的自发性病变,与蜂蜜治疗无关。在每千克体重 24 克剂量组中,一只雄性大鼠出现了非特异性反应,如肾小管细胞局灶性嗜碱性改变,这也被视为自发性病变。根据上述结果,在这项重复剂量口服毒性研究中,确定蜂蜜对 Wistar 大鼠的无观测不良效应水平为每公斤体重 12 克。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
international food research journal
international food research journal Agricultural and Biological Sciences-Food Science
CiteScore
1.40
自引率
0.00%
发文量
75
期刊介绍: The International Food Research Journal (IFRJ) publishes papers in English, six (6) issues a year with the coverage of: Food Science and Technology Nutrition and Dietetics Agriculture, multidisciplinary Chemistry, multidisciplinary The scope of the Journal includes: Food Science, Food Technology and Food Biotechnology Product Development and Sensory Evaluation Food Habits, Nutrition, and Health Food Safety and Quality Food Chemistry, Food Microbiology, Food Analysis and Testing Food Engineering Food Packaging Food Waste Management Food Entrepreneur Food Regulatory Post-Harvest Food Management Food Supply Chain Management Halal Food and Management
期刊最新文献
Effect of chitosan coating and drying on quality of Bombay duck (Harpodon nehereus) Effects of organic acid treatments combined with modified atmosphere packaging on survival of pathogens and quality parameters of meatballs Antihypertensive effects of condiments prepared from fermented legumes: A review Effectiveness of washing with atung (Parinarium glaberimum Hassk) solution on quantity and quality of dark meat yellowfin tuna (Thunnus albacares) surimi Isomerisation of lactose to lactulose in an aqueous solution containing arginine
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1