A 28-day subacute oral toxicity study of Apis cerana (Fabricius) honey in Wistar rats

IF 0.7 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY international food research journal Pub Date : 2023-12-20 DOI:10.47836/ifrj.30.6.11
Hongju Du, Peng Zhang, Shan Zheng, Yanmin Nie, Wenjing Zhang, Ying Feng, Jun-yu Ning, Guojun Li, Shan Gao
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Abstract

The use of honey as food and medicine is widespread, but insufficient data support that it is safe, especially when consumed in high doses. As a result, the present work aimed to investigate the potential toxicity using a repeated dose oral toxicity study. In the toxicity study, Wistar rats were divided into five groups, and orally administered with distilled water (control), 3, 6, 12, and 24 g/kg body weight (BW)/day of honey for 28 days in a row. Body weight, food consumption, clinical pathology, and histopathology were then examined. Significant suppression of body weight, food consumption, and body weight gain was observed at the dose of 24 g/kg BW in both sexes. Honey administration had no statistically significant effect on any of the haematological parameters. The clinical observations, blood coagulation and biochemical parameters, target organs, or histopathology did not reveal any additional nor other treatment-related adverse effects. Mild pathological changes in hepatic tissues were observed in the control, 12, or 24 g/kg BW dose groups, which were common spontaneous lesions unrelated to honey treatment. In the 24 g/kg BW group, one male rat showed non-specific reactions such as focal basophilic change of renal tubule cells, which were also regarded as spontaneous lesions. Based on these results, the no-observed-adverse-effect level (NOAEL) of honey in this repeat dose oral toxicity study was determined to be 12 g/kg BW in both sexes of Wistar rats.
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陶瓷蜂(Fabricius)蜂蜜对 Wistar 大鼠为期 28 天的亚急性毒性口服研究
蜂蜜被广泛用作食品和药物,但没有足够的数据证明它是安全的,尤其是在大剂量食用时。因此,本研究旨在通过重复剂量口服毒性研究来调查蜂蜜的潜在毒性。在毒性研究中,Wistar 大鼠被分为五组,连续 28 天分别口服蒸馏水(对照组)、3、6、12 和 24 克/千克体重(BW)/天的蜂蜜。然后对体重、食量、临床病理学和组织病理学进行检查。在每公斤体重 24 克的剂量下,雌雄大黄蜂的体重、食量和体重增加均受到显著抑制。在统计学上,服用蜂蜜对任何血液学参数都没有显著影响。临床观察、血液凝固和生化参数、靶器官或组织病理学均未发现任何其他与治疗相关的不良反应。对照组、12 克/千克体重组和 24 克/千克体重组的肝组织出现了轻微的病理变化,这是常见的自发性病变,与蜂蜜治疗无关。在每千克体重 24 克剂量组中,一只雄性大鼠出现了非特异性反应,如肾小管细胞局灶性嗜碱性改变,这也被视为自发性病变。根据上述结果,在这项重复剂量口服毒性研究中,确定蜂蜜对 Wistar 大鼠的无观测不良效应水平为每公斤体重 12 克。
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来源期刊
international food research journal
international food research journal Agricultural and Biological Sciences-Food Science
CiteScore
1.40
自引率
0.00%
发文量
75
期刊介绍: The International Food Research Journal (IFRJ) publishes papers in English, six (6) issues a year with the coverage of: Food Science and Technology Nutrition and Dietetics Agriculture, multidisciplinary Chemistry, multidisciplinary The scope of the Journal includes: Food Science, Food Technology and Food Biotechnology Product Development and Sensory Evaluation Food Habits, Nutrition, and Health Food Safety and Quality Food Chemistry, Food Microbiology, Food Analysis and Testing Food Engineering Food Packaging Food Waste Management Food Entrepreneur Food Regulatory Post-Harvest Food Management Food Supply Chain Management Halal Food and Management
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