Paracetamol add-on treatment for perioperative pain management in dogs undergoing single-site thoracolumbar hemilaminectomy: a prospective clinical study

IF 0.2 4区 农林科学 Q4 VETERINARY SCIENCES Vlaams Diergeneeskundig Tijdschrift Pub Date : 2023-12-20 DOI:10.21825/vdt.90044
N.C. Burger, T. Bosmans, S. Bhatti, S. Ooms, B.J.G. Broeckx, I. Polis, L. van Ham, I. Cornelis
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Abstract

In this prospective, double-blinded, randomized, clinical trial, it was evaluated whether paracetamol, as an adjunct to NSAID and opioid analgesia, might limit the requirements for intraoperative fentanyl and postoperative methadone administration in dogs undergoing a singlesite thoracolumbar hemilaminectomy for surgical treatment of an intervertebral disc extrusion. Twelve client-owned dogs were randomly assigned to two multimodal analgesia groups: NSAID + paracetamol group (group NP) and NSAID + placebo group (group N). Intraoperative analgesic assessment was based on the clinical evaluation of a nociceptive response, whereas postoperative analgesic assessment was determined by using the short form of the Glasgow Composite Pain Scale. No statistically significant difference was found in both groups for the intraoperative need for fentanyl (P = 0.18). The probability of having to administer rescue analgesia postoperatively was significantly higher in group N than in group NP (P = 0.01). For both groups, there were no serious side effects reported, nor was any significant difference found between both groups regarding the occurrence of side effects (P = 0.55). Despite multimodal perioperative pain management consisting of a full μ-agonist opioid, a NSAID and paracetamol, intraoperative rescue analgesia was still required, although the need for postoperative opioid based analgesia was significantly lower in group NP.
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为接受单部位胸腰椎半椎板切除术的狗提供扑热息痛附加治疗以控制围手术期疼痛:一项前瞻性临床研究
在这项前瞻性、双盲、随机临床试验中,研究人员评估了扑热息痛作为非甾体抗炎药和阿片类镇痛药的辅助药物,是否可以限制因椎间盘突出症而接受单点胸腰椎半椎板切除术的狗对术中芬太尼和术后美沙酮用药的需求。12 只客户饲养的狗被随机分配到两个多模式镇痛组:非甾体抗炎药+扑热息痛组(NP 组)和非甾体抗炎药+安慰剂组(N 组)。术中镇痛评估基于痛觉反应的临床评估,而术后镇痛评估则通过格拉斯哥综合疼痛量表的简表来确定。两组术中芬太尼用量差异无统计学意义(P = 0.18)。N 组术后需要使用镇痛抢救的概率明显高于 NP 组(P = 0.01)。两组均未报告严重的副作用,两组的副作用发生率也无明显差异(P = 0.55)。尽管围术期疼痛治疗采用了多种模式,包括全效μ-激动剂阿片类药物、非甾体抗炎药和扑热息痛,但仍需要术中抢救性镇痛,不过术后阿片类药物镇痛的需求在NP组明显降低。
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来源期刊
Vlaams Diergeneeskundig Tijdschrift
Vlaams Diergeneeskundig Tijdschrift 农林科学-兽医学
CiteScore
0.40
自引率
0.00%
发文量
29
审稿时长
>36 weeks
期刊介绍: The Vlaams Diergeneeskundig Tijdschrift (ISSN 0303-9021) is a scientific journal that is published bimonthly (six issues per year). It presents mainly clinical topics and addresses itself to two very different readerships: the local Dutch speaking veterinarians in Belgium and the Netherlands, and the international veterinary and biomedical research community. Each issue contains scientific papers either in English, or in Dutch with an English abstract.
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