Myo-inositol versus metformin effects on clinical features, endocrine and metabolic profiles in infertile women with polycystic ovary syndrome: A randomized controlled trial

IF 0.5 Q4 REPRODUCTIVE BIOLOGY Asian Pacific Journal of Reproduction Pub Date : 2023-12-01 DOI:10.4103/2305-0500.390300
N.S.V. Le, Minh Tam Le, T. N. Cao
{"title":"Myo-inositol versus metformin effects on clinical features, endocrine and metabolic profiles in infertile women with polycystic ovary syndrome: A randomized controlled trial","authors":"N.S.V. Le, Minh Tam Le, T. N. Cao","doi":"10.4103/2305-0500.390300","DOIUrl":null,"url":null,"abstract":"\n \n To compare the effectiveness of inositol and metformin on the clinical characteristics, and endocrine and metabolic profiles of infertile polycystic ovarian syndrome (PCOS) women from Vietnam.\n \n \n \n From June 2018 to August 2022, a randomized trial was undertaken at the Hue Center for Endocrinology and Reproduction on infertile women aged 18 to 40 years with polycystic ovarian syndrome. The clinical, endocrine, and metabolic features of these individuals were assessed before and after 3 months of treatment with 2 g of inositol or 1700 mg of metformin per day. Natural pregnancy rates, adverse effects, and tolerance of inositol were recorded.\n \n \n \n The study included 171 infertile PCOS women who were eligible to participate and took part in the baseline assessment, of whom 132 women participated in data analysis after 3 months. After metformin treatment, 42.1% of women with oligomenorrhea experienced regular menstruation. Metformin significantly lowered body mass index (BMI), waist circumference and testosterone levels, but had no effect on other clinical characteristics, endocrine profiles, or metabolic profiles. 29.2% Of women reported experiencing side effects. 21% Of them attained pregnancy, which resulted in 17.1% of live births. In the inositol group, the rate of regular cycle increased by 18.2% and the total testosterone concentration significantly decreased. In overweight/obese women with PCOS, inositol significantly decreased weight, BMI, waist and hip circumferences (P<0.05). 100% Of women tolerated inositol and continued treatment. 18.9% Of them became pregnant, leading to 17% of live births.\n \n \n \n Metformin and inositol can improve weight and waist circumference in overweight/obese infertile women with PCOS. Metformin is associated with a higher rate of regular menstruation, whereas inositol is associated with a lower rate of adverse effects. The spontaneous conception, clinical pregnancy, and live birth rates between two groups are comparable.\n","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"535 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Reproduction","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/2305-0500.390300","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"REPRODUCTIVE BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

To compare the effectiveness of inositol and metformin on the clinical characteristics, and endocrine and metabolic profiles of infertile polycystic ovarian syndrome (PCOS) women from Vietnam. From June 2018 to August 2022, a randomized trial was undertaken at the Hue Center for Endocrinology and Reproduction on infertile women aged 18 to 40 years with polycystic ovarian syndrome. The clinical, endocrine, and metabolic features of these individuals were assessed before and after 3 months of treatment with 2 g of inositol or 1700 mg of metformin per day. Natural pregnancy rates, adverse effects, and tolerance of inositol were recorded. The study included 171 infertile PCOS women who were eligible to participate and took part in the baseline assessment, of whom 132 women participated in data analysis after 3 months. After metformin treatment, 42.1% of women with oligomenorrhea experienced regular menstruation. Metformin significantly lowered body mass index (BMI), waist circumference and testosterone levels, but had no effect on other clinical characteristics, endocrine profiles, or metabolic profiles. 29.2% Of women reported experiencing side effects. 21% Of them attained pregnancy, which resulted in 17.1% of live births. In the inositol group, the rate of regular cycle increased by 18.2% and the total testosterone concentration significantly decreased. In overweight/obese women with PCOS, inositol significantly decreased weight, BMI, waist and hip circumferences (P<0.05). 100% Of women tolerated inositol and continued treatment. 18.9% Of them became pregnant, leading to 17% of live births. Metformin and inositol can improve weight and waist circumference in overweight/obese infertile women with PCOS. Metformin is associated with a higher rate of regular menstruation, whereas inositol is associated with a lower rate of adverse effects. The spontaneous conception, clinical pregnancy, and live birth rates between two groups are comparable.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肌醇与二甲双胍对多囊卵巢综合征不孕妇女临床特征、内分泌和代谢特征的影响:随机对照试验
目的:比较肌醇和二甲双胍对越南多囊卵巢综合征(PCOS)不孕妇女的临床特征、内分泌和代谢特征的有效性。 2018年6月至2022年8月,顺化内分泌与生殖中心对18至40岁患有多囊卵巢综合征的不孕妇女进行了随机试验。在每天服用 2 克肌醇或 1700 毫克二甲双胍治疗 3 个月前后,对这些人的临床、内分泌和代谢特征进行了评估。同时还记录了自然怀孕率、不良反应以及对肌醇的耐受性。 该研究包括171名符合条件并参加了基线评估的多囊卵巢综合征不孕妇女,其中132名妇女参加了3个月后的数据分析。接受二甲双胍治疗后,42.1%的少经妇女月经正常。二甲双胍能明显降低体重指数(BMI)、腰围和睾酮水平,但对其他临床特征、内分泌特征或代谢特征没有影响。29.2%的妇女表示出现了副作用。其中 21% 的妇女怀孕,活产率为 17.1%。在肌醇组中,正常周期的比率增加了 18.2%,总睾酮浓度显著下降。在患有多囊卵巢综合症的超重/肥胖妇女中,肌醇能明显降低体重、体重指数、腰围和臀围(P<0.05)。100%的妇女能够耐受肌醇并继续接受治疗。其中 18.9% 的妇女怀孕,活产率为 17%。 二甲双胍和肌醇可以改善患有多囊卵巢综合症的超重/肥胖不孕妇女的体重和腰围。二甲双胍与较高的月经规律率有关,而肌醇与较低的不良反应率有关。两组患者的自然受孕率、临床妊娠率和活产率相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Asian Pacific Journal of Reproduction
Asian Pacific Journal of Reproduction Veterinary-Veterinary (all)
CiteScore
1.70
自引率
0.00%
发文量
588
审稿时长
9 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.
期刊最新文献
Myo-inositol versus metformin effects on clinical features, endocrine and metabolic profiles in infertile women with polycystic ovary syndrome: A randomized controlled trial Seasonal stress on semen quality profiles, seminal biochemical and oxidative stress attributes in endangered Teressa goat of Andaman and Nicobar Islands Embryonic, genetic and clinical outcomes of fresh versus vitrified oocyte: A retrospective cohort study Expression of VEGF165 and VEGF165b during ovarian follicular development Oxidative stress in male infertility and therapeutic approach: A mini-review
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1