Architectonics of parenchymal organs of white rats under conditions of induced immunosuppression and the use of Interferon lambda

Abstract

Violation of the functioning of the organs of the immune system, both in humans and in animals, is due to the influence of unfavorable factors of natural and anthropogenic origin on the body, as well as infectious diseases of various etiologies. The article discusses changes in the architectonics  of parenchymal organs of white laboratory rats after exposure to the drug interferon lambda on  the  background  of  cyclophosphamide (CF). It was found that modeling of immunosuppression through the use of CF led to a decrease  in  the  number  of  lymphoid  cells and the appearance of foci of accumulation of  blast  cells  and  megakaryocytes,  which indicates a lesion of lymphoid and hematopoietic tissues. In addition, an immunosuppressive effect on the spleen was revealed, the mass coefficient of which in the group with the use of CF was increased 3.53 times, in the group with the simultaneous use of CF and the drug interferon lambda – 2.75 times relative to the control group.  There was also a decrease in the mass coefficient of the thymus  by  47.6-50.0%  in  the  same  groups, which can be regarded as damage to the organs  of  the  immune  system.  The negative effect of CF on the spleen was confirmed by histological examination. Thus, when inducing immunosuppression, the loss of  white pulp was 73.0-77.5% relative to the group of control animals, which is 20.0% higher than in rats treated with interferon lambda, which may indicate a positive immunotropic effect of the drug under study. In addition, no significant morphological changes were detected  when  the  body  of  healthy  rats  was  exposed  to  interferon  lambda  in  the  studied organs, the morphological picture is similar to that of intact animals, which may indicate the safety of its use to animals.