The efficacy of HDDPiW-jSB solution on docetaxel-induced alopecia of rats.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI:10.1080/15569527.2023.2300790
Bilgin Demir, Buket Demirci, Canten Tataroglu, Sabri Barutca, Duygu Barutca
{"title":"The efficacy of HDDPiW-jSB solution on docetaxel-induced alopecia of rats.","authors":"Bilgin Demir, Buket Demirci, Canten Tataroglu, Sabri Barutca, Duygu Barutca","doi":"10.1080/15569527.2023.2300790","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.</p><p><strong>Material and methods: </strong>Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.</p><p><strong>Results: </strong>In the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.</p><p><strong>Conclusion: </strong>Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"113-119"},"PeriodicalIF":1.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutaneous and Ocular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569527.2023.2300790","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.

Material and methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.

Results: In the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.

Conclusion: Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
HDDPiW-jSB 溶液对多西他赛引起的大鼠脱发的疗效。
研究目的化疗诱导性脱发(CIA)是癌症患者最常见的副作用之一,但目前尚无有效的药物治疗方法。本研究旨在研究新开发的 HDDPiW-jSB 溶液对多西他赛(DTX)诱导的大鼠脱发模型的保护作用:给 6-8 个月大的大鼠注射多西他赛(10 毫克/千克/周)三周。HDDPiW-jSB 溶液在 DTX 一周前开始使用,每周一次或两次,连续使用 4 周。用苏木精-伊红和免疫组织化学染色法对大鼠毛囊进行评估:在该研究的第一阶段,使用 DTX(10 毫克/千克/三次)成功地导致了脱发。在研究的第二阶段,使用 HDDPiW-jSB 溶液并没有明显改变对照组的研究参数。该溶液改善了 DTX 诱导的脱发大鼠组皮肤样本中的新生毛囊数量和 Bcl-2 水平,尤其是在每周使用两次的情况下。此外,Caspase 3 的水平也有所下降。结论:外用 HDDPiW-jSB 溶液对皮肤是安全的:结论:外用 HDDPiW-jSB 溶液可有效、安全地保护 DTX 引起的脱发大鼠模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
期刊最新文献
Effect of elamipretide and methylprednisolone treatment on optic nerve, retina and brain damage in a methanol poisoning model: biochemical and histopathological evaluation. Effects on corneal endothelium of intravitreal injection of anti-VEGF drugs. Correction. Isotretinoin increases non-insulin-based surrogate markers of insulin resistance in acne vulgaris patients. The treatment efficacy of 7.5% dapsone gel in papulopustular rosacea: a prospective study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1