High sensitivity and ultra-low concentration range photoacoustic spectroscopy based on trapezoid compound ellipsoid resonant photoacoustic cell and partial least square

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2023-12-30 DOI:10.1016/j.pacs.2023.100583

Qiaoyun Wang , Shunyuan Xu , Ziheng Zhu , Jilong Wang , Xin Zou , Chu Zhang , Qiang Liu

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Abstract

A high sensitivity and ultra-low concentration range photoacoustic spectroscopy (PAS) gas detection system, which was based on a novel trapezoid compound ellipsoid resonant photoacoustic cell (TCER-PAC) and partial least square (PLS), was proposed to detect acetylene (C₂H₂) gas. In the concentration range of 0.5 ppm ∼ 10.0 ppm, the limit of detection (LOD) values of TCER-PAC-based PAS system without data processing was 66.4 ppb, which was lower than that of the traditional trapezoid compound cylindrical resonant photoacoustic cell (TCCR-PAC). The experimental results indicated that the TCER-PAC had higher sensitivity than of TCCR-PAC. Within the concentration range of 12.5 ppb ∼ 125.0 ppb, the LOD and limit of quantification (LOQ) of TCER-PAC-based PAS system combined with PLS regression algorithm were 1.1 ppb and 3.7 ppb, respectively. The results showed that higher detection sensitivity and lower LOD were obtained by PAS system with TCER-PAC and PLS than that of TCCR-PAC-based PAS system.

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基于梯形复合椭球谐振光声单元和偏最小二乘法的高灵敏度和超低浓度范围光声光谱技术

基于新型梯形复合椭球谐振光声池（TCER-PAC）和偏最小二乘法（PLS）的高灵敏度和超低浓度范围光声谱（PAS）气体检测系统被提出来用于检测乙炔（C2H2）气体。在 0.5 ppm ～ 10.0 ppm 的浓度范围内，基于 TCER-PAC 的 PAS 系统在不进行数据处理的情况下的检出限（LOD）值为 66.4 ppb，低于传统的梯形复合圆柱谐振光声电池（TCCR-PAC）。实验结果表明，TCER-PAC 的灵敏度高于 TCCR-PAC。在 12.5 ppb ∼ 125.0 ppb 的浓度范围内，基于 TCER-PAC 的 PAS 系统结合 PLS 回归算法的检测灵敏度（LOD）和定量限（LOQ）分别为 1.1 ppb 和 3.7 ppb。结果表明，与基于 TCCR-PAC 的 PAS 系统相比，基于 TCER-PAC 和 PLS 的 PAS 系统具有更高的检测灵敏度和更低的 LOD。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.