Meaning in life and Parkinson’s disease in the UK Biobank

IF 1.9 Q3 CLINICAL NEUROLOGY Clinical Parkinsonism Related Disorders Pub Date : 2024-01-01 DOI:10.1016/j.prdoa.2023.100231

Angelina R. Sutin , Martina Luchetti , Yannick Stephan , Antonio Terracciano

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Abstract

Introduction

Meaning in life is an aspect of eudaimonic well-being associated with lower dementia risk. This research examines whether this protective association extends to Parkinson’s disease (PD).

Methods

Participants (N = 153,569) from the UK Biobank reported on their meaning in life. Cases of PD were identified through health records.

Results

Meaning in life was associated with a 50 % lower likelihood of prevalent PD (OR = 0.68, 95 % CI = 0.59–0.78). Over the 5-year follow-up, meaning was associated with a 35 % lower risk of incident PD (HR = 0.74, 95 % CI = 0.65–0.83), an association robust to sociodemographic characteristics, depression, history of seeking mental health care, smoking, physical activity, and genetic risk and not moderated by age, sex, education, deprivation, or genetic risk.

Conclusions

Meaning in life is associated with lower risk of incident PD, an association independent of other major risk factors and generalizable across sociodemographic groups. Meaning is a promising target of intervention for common neurodegenerative diseases.

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英国生物数据库中的生命意义与帕金森病

导言：人生意义是与降低痴呆症风险相关联的幸福感的一个方面。本研究探讨了这种保护性关联是否延伸至帕金森病（PD）。方法来自英国生物库的参与者（N = 153,569 人）报告了他们的生活意义。结果生活意义与帕金森病发病率降低 50% 相关（OR = 0.68，95 % CI = 0.59-0.78）。在为期5年的随访中，"生活中的意义 "与帕金森病发病风险降低35%有关（HR = 0.74, 95 % CI = 0.65-0.83），这种关联与社会人口特征、抑郁、寻求心理保健的历史、吸烟、体育锻炼和遗传风险密切相关，且不受年龄、性别、教育程度、贫困程度或遗传风险的影响。对于常见的神经退行性疾病，意义是一个很有前景的干预目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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