The effect of n-3 polyunsaturated fatty acids on inflammation status in cancer patients: Updated systematic review and dose- and time-response meta-analysis

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-12-24 DOI:10.1016/j.phanu.2023.100372
Mehrdad Jamali , Meysam Zarezadeh , Parsa Jamilian , Zohreh Ghoreishi
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Abstract

Background

Reducing inflammation levels can potentially reduce treatment-induced complications in cancer patients. This meta-analysis aimed to determine the effect of n-3 PUFAs on three main biomarkers of inflammation: tumor necrosis factor-α(TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6).

Methods

A systematic search was conducted on PubMed, Scopus, and the Web of Science databases to find relevant studies. The difference between the intervention and control arms results was assessed by standardized mean differences (SMD) along with a 95% confidence interval.

Result

The study found that the SMD for TNF-α, CRP, and IL-6 was −0.63(95%CI:−0.89,−0.37, P < 0.001), −0.27(95%CI:−0.64,0.10, P = 0.15), −0.59(95%CI:−0.89,−0.29, P < 0.001) respectively, comparing the effects of n-3 PUFAs on study subjects compared to control. Subgroup analyses revealed heterogeneity sources for TNF-α and IL-6 but not for CRP. The study did not detect any indication of publication bias in the cases of TNF-α and CRP but detected it for IL-6.

Conclusion

N-3 PUFAs caused a significant reduction in levels of TNF-α IL-6 but not CRP in cancer patients. The findings support that n-3 PUFAs could be used as an add-on treatment for cancer patients, possibly because they reduce inflammation and do not have any known side effects in moderate doses.

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n-3 多不饱和脂肪酸对癌症患者炎症状态的影响:最新系统综述及剂量和时间反应荟萃分析
背景降低炎症水平有可能减少癌症患者因治疗引起的并发症。这项荟萃分析旨在确定 n-3 PUFAs 对肿瘤坏死因子-α(TNF-α)、C 反应蛋白(CRP)和白细胞介素-6(IL-6)这三种主要炎症生物标志物的影响。方法在 PubMed、Scopus 和 Web of Science 数据库中进行系统搜索,以找到相关研究。结果研究发现,TNF-α、CRP和IL-6的SMD为-0.63(95%CI:-0.89,-0.37,P = 0.001)、-0.27(95%CI:-0.64,0.10,P = 0.15)、-0.59(95%CI:-0.89,-0.29,P = 0.001)。亚组分析显示,TNF-α和IL-6存在异质性,但CRP不存在异质性。结论n-3 PUFAs能显著降低癌症患者的TNF-α IL-6水平,但不能降低CRP水平。研究结果表明,n-3 PUFAs 可作为癌症患者的辅助治疗药物,这可能是因为适量的 n-3 PUFAs 可减轻炎症反应,而且没有任何已知的副作用。
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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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