MALIGNANT NEOPLASMS OF THE RESPIRATORY AND THORACIC ORGANS IN THE REMOTE PERIOD IN MALES OF ALTAI KRAI AFFECTED BY FIRST NUCLEAR TEST AT SEMIPALATINSK TEST SITE

Abstract

The morbidity of malignant neoplasms of respiratory organs and thorax in the remote period in the male population born from 1932 to 1949 in rural settlements of Altai Krai and traced during the first trial was evaluated. Purpose: To study the morbidity of malignant neoplasms of respiratory and thoracic organs in the remote period in the male population born in 1932-1949 and located in the zone of influence of the first test. METHODS: The cohort study was based on the examination of anonymized data and operational information on first-time detected and morphologically verified cases of malignant neoplasms from 2007 to 2016. A cohort fixed by the date of the first nuclear test of 6383 individuals was studied. The main (exposed) cohort included 2291 people and the control (unexposed) cohort included 4092 people. In the cohort, 156 cases of respiratory and thoracic malignant neoplasm were identified. Person-time incidence rate PtR, standard error (mPtR) and confidence intervals (95% CI) were calculated. The incidence of respiratory and thoracic malignant neoplasms, structure and relative risk were assessed. Statistical processing of data was performed using Microsoft Office 2016 licensed software. Results: The number of person-years spent at risk of respiratory and thoracic malignant neoplasms in the male population in the main cohort is equal to 16731 person-years, in the control cohort - 30747. The person-time incident rate (PtR) in the main cohort was 436.32 105 person-years, with an mPtR of 51.07 and confidence intervals (95% CI) of 334.18 to 538.45, while in the control cohort the PTR was 269.95 105 person-years with an mPtR of 29.63 and (95% CI) of 210.68 to 329.21, respectively. Leading localizations: bronchial and lung and laryngeal malignancies. Conclusions. We found an increased relative risk of respiratory and thoracic malignancies in the male population in the remote period (RR=1.616; (95% CI) 1.180 - 2.214), with a standard error of relative risk (s) equal to 0.160.