Роль нейтрофилов опухолевого микроокружения в прогрессии люминального HER2-негативного раннего рака молочной железы

Abstract

Background. Luminal Her2-negative breast cancers is the most common type of tumor in women diagnosed with early-stage breast cancer. Stromal cells and immune cells in tumor microenvironment have been reported to have significant value in prognosis of cancers. The prognostic role of tumor-associated neutrophils in early breast cancer remains mostly unclear. Materials. The dataset consisted of 60 patients with early luminal HER2-negative breast cancer treated in Botkin Hospital. We first estimated basic morphological signs: tumor size, tumor grade by Nottingham Score, tumor-infiltrating lymphocytes, lymphovascular invasion, hormonal receptors status, proliferative index, regional lymph nodes status. The expressions of intratumoral CD15-neutrophyls was studied using immunohistochemistry. Results. High tumor-associated neutrophils concentration was correlated with tumor size, high grade tumors, proliferative index, tumor-infiltrating lymphocytes, lymphovascular invasion and positive regional lymph nodes. Conclusions: Tumor-associated neutrophils predicted a worse prognosis in early luminal Her2-negative breast cancer.