Precision medicine in myocardial infarction: Nanotheranostic strategies

Nano Select Pub Date : 2023-12-13 DOI:10.1002/nano.202300127
Alexander Shao‐Rong Pang, Vishalli Dinesh, Natalie Yan‐Lin Pang, Tarini Dinesh, Kimberley Yun‐Lin Pang, G. W. Yip, B. Bay, Dinesh Kumar Srinivasan
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Abstract

Myocardial infarction (MI) is the most prevalent non‐communicable disease worldwide. Nanotheranostics have made significant progress in the biomedical field, presenting an avenue to overcome the limitations of conventional approaches towards MI, in which personalized interventions have enhanced nanotherapeutic efficacy. The pharmacokinetics and pharmacodynamics of nanoscale materials have been modified through alteration of their physical and chemical properties such as structure, size, and surface, thereby improving target sensitivity and specificity. This revolutionary technology has also been accomplished through precision therapeutics in MI. In this review, we discuss advanced nanoparticle designs utilized in the diagnosis and treatment of MI that could be applied to deliver personalized treatment and improve patient outcomes.
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心肌梗塞的精准医疗:纳米治疗策略
心肌梗塞(MI)是全球最普遍的非传染性疾病。纳米otheranostics 在生物医学领域取得了重大进展,为克服心肌梗塞传统治疗方法的局限性提供了一条途径,其中个性化干预增强了纳米治疗效果。通过改变纳米级材料的结构、尺寸和表面等物理和化学特性,纳米级材料的药代动力学和药效学得到了改变,从而提高了靶点的敏感性和特异性。这一革命性技术也已通过 MI 的精准治疗得以实现。在这篇综述中,我们将讨论在心肌梗死诊断和治疗中使用的先进纳米粒子设计,这些设计可用于提供个性化治疗并改善患者预后。
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