Determination of phytochemical and antibacterial properties of Momordica charantia seed extracts

Celal Bayar Üniversitesi Fen Bilimleri Dergisi Pub Date : 2023-11-22 DOI:10.18466/cbayarfbe.1292919

Mehzat Altun, Zerife Orhan

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Abstract

In recent years, it is essential to discover safe and effective antibacterial drugs because of rising antibiotic-resistant bacteria. In traditional medicine, plant extracts including biological active components have been used for therapeutic purposes. We aimed to evaluate the antimicrobial properties of the aqueous seed extract of Momordica charantia (M.charantia) on 9 pathogenic bacteria. The antibacterial activity of the extract was assessed against strains using disc diffusion and broth microdilution tests. A total of 21 constituents were identified from M.charantia seeds. Alcohols, esters, aldehydes, monoterpenes, and monoterpenoids were found as the prevalent groups. The seed extract showed the greatest antimicrobial activity on B.subtilis and S.aureus with an inhibition zone diameter (IZD) value of 15.75±0.50 mm and 15.25±0.957 mm, respectively. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) test results ranged from 12.5 to 100 (mg/mL). The seed extract of M.charantia could be used for the cure of bacterial infections as a new natural drug.

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确定 Momordica charantia 种子提取物的植物化学成分和抗菌特性

近年来，由于抗生素耐药菌的不断增加，发现安全有效的抗菌药物至关重要。在传统医学中，包括生物活性成分在内的植物提取物一直被用于治疗目的。我们的目的是评估 Momordica charantia（M.charantia）种子水提取物对 9 种病原菌的抗菌特性。采用盘扩散和肉汤微稀释试验评估了提取物对菌株的抗菌活性。从木香种子中总共鉴定出 21 种成分。醇类、酯类、醛类、单萜烯类和单萜烯类为主要成分。种子提取物对枯草杆菌和金黄色葡萄球菌的抗菌活性最强，抑菌区直径（IZD）分别为 15.75±0.50 mm 和 15.25±0.957 mm。最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测试结果介于 12.5 至 100（mg/mL）之间。黑木耳种子提取物可作为一种新的天然药物用于治疗细菌感染。

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Celal Bayar Üniversitesi Fen Bilimleri Dergisi

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