A Low Cost, Flexible Atmospheric Pressure Plasma Jet Device With Good Antimicrobial Efficiency

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2023-12-13 DOI:10.1109/TRPMS.2023.3342709
Fellype do Nascimento;Aline da Graça Sampaio;Noala Vicensoto Moreira Milhan;Aline Vidal Lacerda Gontijo;Philipp Mattern;Torsten Gerling;Eric Robert;Cristiane Yumi Koga-Ito;Konstantin Georgiev Kostov
{"title":"A Low Cost, Flexible Atmospheric Pressure Plasma Jet Device With Good Antimicrobial Efficiency","authors":"Fellype do Nascimento;Aline da Graça Sampaio;Noala Vicensoto Moreira Milhan;Aline Vidal Lacerda Gontijo;Philipp Mattern;Torsten Gerling;Eric Robert;Cristiane Yumi Koga-Ito;Konstantin Georgiev Kostov","doi":"10.1109/TRPMS.2023.3342709","DOIUrl":null,"url":null,"abstract":"Plasma sources suitable to generate low-temperature plasmas has been fundamental for the advances in plasma medicine. In this research field, plasma sources must comply with stringent conditions for clinical applications. The main requirement to be met is the patient and operator’s safety and the ethical requirement of effectivity, which encompasses the electrical regulations, potential device toxicity, and effectiveness in relation to the desired treatment. All these issues are addressed by the German prestandard DIN SPEC 91315:2014–06 (DINSpec), which deals with the safety limits, risk assessment, and biological efficacy of plasma sources aimed for medical applications. In this work, a low cost, user-friendly, and flexible atmospheric pressure plasma jet (APPJ) device was characterized following the DINSpec guidelines. The device, which is still under development, proved to be safe for medical applications. It is capable of producing an APPJ with low patient leakage current and ultraviolet emission, gas temperature lower than 40 °C, production of harmful gases within the safety limits and low cytotoxicity. The most differentiating feature is that the device presented good antimicrobial efficacy even operating at frequency of the order of just a few hundred Hz, a value below that of most devices reported in the literature.","PeriodicalId":46807,"journal":{"name":"IEEE Transactions on Radiation and Plasma Medical Sciences","volume":"8 3","pages":"307-322"},"PeriodicalIF":4.6000,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Radiation and Plasma Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10359143/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Plasma sources suitable to generate low-temperature plasmas has been fundamental for the advances in plasma medicine. In this research field, plasma sources must comply with stringent conditions for clinical applications. The main requirement to be met is the patient and operator’s safety and the ethical requirement of effectivity, which encompasses the electrical regulations, potential device toxicity, and effectiveness in relation to the desired treatment. All these issues are addressed by the German prestandard DIN SPEC 91315:2014–06 (DINSpec), which deals with the safety limits, risk assessment, and biological efficacy of plasma sources aimed for medical applications. In this work, a low cost, user-friendly, and flexible atmospheric pressure plasma jet (APPJ) device was characterized following the DINSpec guidelines. The device, which is still under development, proved to be safe for medical applications. It is capable of producing an APPJ with low patient leakage current and ultraviolet emission, gas temperature lower than 40 °C, production of harmful gases within the safety limits and low cytotoxicity. The most differentiating feature is that the device presented good antimicrobial efficacy even operating at frequency of the order of just a few hundred Hz, a value below that of most devices reported in the literature.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
具有良好抗菌效率的低成本、灵活的常压等离子喷射装置
适合产生低温等离子体的等离子体源是等离子体医学发展的基础。在这一研究领域,等离子源必须符合临床应用的严格条件。需要满足的主要要求是病人和操作者的安全以及有效性的道德要求,其中包括电气法规、潜在的设备毒性以及与所需治疗相关的有效性。德国预标准 DIN SPEC 91315:2014-06(DINSpec)解决了所有这些问题,该标准涉及医疗应用等离子源的安全限制、风险评估和生物功效。在这项工作中,我们根据 DINSpec 指南,对一种低成本、用户友好且灵活的常压等离子体喷射(APPJ)设备进行了鉴定。该设备仍在开发中,但已证明可安全用于医疗应用。它能够生产出患者漏电流和紫外线辐射低、气体温度低于 40 {/deg}C、有害气体产生量在安全范围内、细胞毒性低的 APPJ。最与众不同的是,该设备即使在几百赫兹的频率下工作,也能产生良好的抗菌效果,这一数值低于文献中报道的大多数设备。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
期刊最新文献
Affiliate Plan of the IEEE Nuclear and Plasma Sciences Society Table of Contents IEEE Transactions on Radiation and Plasma Medical Sciences Information for Authors IEEE Transactions on Radiation and Plasma Medical Sciences Publication Information Three-Gamma Imaging in Nuclear Medicine: A Review
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1