Transgenic Embryo Implantation Excerpts from The Life Cycle of The Programmed Mouse, an Art and Biology Residency in an Experimental Animal Production and Research Facility

Adam Zaretsky
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Abstract

This is an excerpt from a record of a bioart residency in the transgenic mouse production facility at i3S, University Porto, Porto, Portugal, EU 2022: Art/sci research-creation, field notes and bioart from the i3S transgenic mouse production facility. The transgenic mouse production facility at i3S is an animal facility that breeds specific transgenic mutants for lab research. This means that the mice are genetically modified and bred to produce stable litters of similarly mutant pups. In other words, the mice are genetically modified in such a way that their offspring are altered in a specific hereditary and multigenerational way. Covering the life cycle of the programmed mouse, we asked for hands-on experience as much as possible and learned through doing/witnessing: mouse sperm/egg collection, cryopreservation, fertilization, embryo mutagenic microinjection, implantation of embryos in a pseudopregnant surrogate, embryo dissection for tissue culture, surgery, breeding, and euthanasia. Delving into software studies, there was an exploration of CRISPR/vector design apps and transgenic animal facility management apps. We also accessed global networks for stable pedigree proof of genomic standardization as well as animal care and use in the transgenic core. Learning that the mice were often disease models, created to infect with live contagious diseases or inborn with developmental disabilities (degenerative enhancements), we arranged for some animal enrichment arts. Learning of the often-difficult life of scientists and graduate students, we also took the time to enrich the scientists with an action painting to live music enrichment lab. This form of in depth and experiential research is an advanced version of medical anthropology or science technology studies field working with subjective, literary, informed, morbid, and humorous artistic outcomes.
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转基因胚胎植入 摘自《程序化小鼠的生命周期》,实验动物生产和研究机构的艺术与生物学实习项目
本文摘自在葡萄牙波尔图波尔图大学 i3S 转基因小鼠生产设施的生物艺术驻留记录,欧盟 2022 年:来自 i3S 转基因小鼠生产设施的艺术/科学研究-创作、现场笔记和生物艺术。i3S 的转基因小鼠生产设施是为实验室研究培育特定转基因突变体的动物设施。这意味着小鼠是经过基因改造的,繁殖后能产生稳定的类似突变体幼仔。换句话说,对小鼠进行基因改造后,它们的后代会以特定的遗传和多代方式发生改变。 在程序小鼠的整个生命周期中,我们要求尽可能多地亲身体验,并通过亲手操作/亲眼目睹来学习:小鼠精子/卵子的采集、冷冻保存、受精、胚胎诱变显微注射、胚胎植入假孕代孕体、用于组织培养的胚胎解剖、手术、繁殖和安乐死。在软件研究方面,我们探索了 CRISPR/载体设计应用程序和转基因动物设施管理应用程序。我们还访问了全球网络,以获得基因组标准化的稳定血统证明,以及转基因核心的动物护理和使用。了解到小鼠通常是疾病模型,用于感染活体传染性疾病或先天性发育障碍(退行性增强),我们安排了一些动物强化艺术。了解到科学家和研究生的生活往往比较艰苦,我们还抽出时间为科学家们安排了现场音乐丰富实验室。这种深入的体验式研究形式是医学人类学或科学技术研究领域的高级版本,其艺术成果具有主观性、文学性、知情性、病态性和幽默性。
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