{"title":"Methylene blue-mediated photodynamic therapy for the treatment of oral leukoplakia","authors":"Akanksha Bhandari, Akansha Budakoti, Manjari Chaudhary","doi":"10.4103/jss.jss_97_23","DOIUrl":null,"url":null,"abstract":"Objective: To evaluate the efficacy of methylene blue-mediated photodynamic therapy (MB-PDT) for the treatment of oral leukoplakia (OL) and compare it to systemic Vitamin A therapy. Materials and Methods: Forty clinically and histopathologically confirmed cases of OL were included. They were divided into two groups: 20 were given systemic Vitamin A therapy and on the other group MB-PDT for 30 days. Pre- and posttreatment assessment of size of lesion and clinical appearance were done and followed up for 1 year to check for recurrence and delayed side effects. Results: The reduction in size of lesion pre- and posttreatment was statistically nonsignificant in the Vitamin A Group, but statistically highly significant in the PDT group according to unpaired t-test with no immediate or delayed side effects seen in both the groups. Conclusion: Both the treatment methods showed response in terms of reduction of size of lesion, but MB-PDT was a better treatment option for OL. Clinical Relevance: Oral cancer is often preceded by various premalignancies, OL being the most common among them. Early diagnosis and intervention will prevent malignant transformation thereby reducing the cost, side effect and mortality associated with oral cancer. Considering the prevalence, symptomless nature of OL, an effective, well-accepted mode of treatment with minimal side effects is of utmost need.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Scientific Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jss.jss_97_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To evaluate the efficacy of methylene blue-mediated photodynamic therapy (MB-PDT) for the treatment of oral leukoplakia (OL) and compare it to systemic Vitamin A therapy. Materials and Methods: Forty clinically and histopathologically confirmed cases of OL were included. They were divided into two groups: 20 were given systemic Vitamin A therapy and on the other group MB-PDT for 30 days. Pre- and posttreatment assessment of size of lesion and clinical appearance were done and followed up for 1 year to check for recurrence and delayed side effects. Results: The reduction in size of lesion pre- and posttreatment was statistically nonsignificant in the Vitamin A Group, but statistically highly significant in the PDT group according to unpaired t-test with no immediate or delayed side effects seen in both the groups. Conclusion: Both the treatment methods showed response in terms of reduction of size of lesion, but MB-PDT was a better treatment option for OL. Clinical Relevance: Oral cancer is often preceded by various premalignancies, OL being the most common among them. Early diagnosis and intervention will prevent malignant transformation thereby reducing the cost, side effect and mortality associated with oral cancer. Considering the prevalence, symptomless nature of OL, an effective, well-accepted mode of treatment with minimal side effects is of utmost need.
目的评估亚甲蓝介导的光动力疗法(MB-PDT)治疗口腔白斑病(OL)的疗效,并将其与全身性维生素 A 治疗进行比较。材料与方法:纳入 40 例经临床和组织病理学证实的 OL 病例。他们被分为两组:20 人接受全身维生素 A 治疗,另一组接受 MB-PDT 治疗 30 天。治疗前和治疗后对病灶大小和临床表现进行评估,并随访一年,以检查复发和延迟副作用。结果根据非配对 t 检验,维生素 A 组治疗前和治疗后皮损面积的缩小在统计学上无显著性差异,但 PDT 组在统计学上有高度显著性差异,且两组均未出现即刻或延迟副作用。结论两种治疗方法在缩小病灶方面都有反应,但 MB-PDT 是治疗 OL 的更好选择。临床意义:口腔癌发生前往往存在各种前恶性肿瘤,OL 是其中最常见的一种。早期诊断和干预可预防恶性转化,从而降低与口腔癌相关的费用、副作用和死亡率。考虑到 OL 的普遍性和无症状性,最需要的是一种有效、广为接受且副作用最小的治疗模式。