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A Paradigm Shift in Prosthodontics: Analog to Digital 修复学的范式转变:模拟到数字
IF 0.3 Pub Date : 2024-04-18 DOI: 10.4103/jss.jss_100_23
Sapna Rani, Pankaj Dhawan, Jigyasa Gupta, Juhi Singhla
Evolution happens in our everyday lifestyles in each field and prosthodontics is no exception to it. A new technology of sufferers is predicted to have new aspirations and desires. To fulfill these desires, it is our obligation to be updated with each expertise and capabilities about new developments in prosthodontics, so that these aspirations can be met. Although conventional techniques have worked satisfactorily for decades, with the growth of digital dentistry, conventional methods have become redundant. Digital methods are more accurate, efficient, less time-consuming, simpler, faster, and believed to have a better potential than conventional methods. This paper gives perception of trends and standards applied in modern prosthodontics and how they have an edge with the existing traditional or conventional methods used in the field.
在我们的日常生活中,每个领域都在发生变化,口腔修复学也不例外。据预测,新技术的患者会有新的愿望和需求。为了满足这些愿望,我们有义务不断更新有关修复学新发展的专业知识和能力,从而满足这些愿望。尽管传统技术几十年来一直在令人满意地发挥作用,但随着数字牙科技术的发展,传统方法已经变得多余。与传统方法相比,数字化方法更准确、更高效、更省时、更简单、更快捷,而且被认为具有更好的潜力。本文介绍了现代口腔修复学的发展趋势和标准,以及它们与该领域现有的传统或常规方法相比的优势。
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引用次数: 0
Proportion of Urinary Tract Infection in Children between 6 Months to 5 Years of Age Presenting with Fever 6 个月至 5 岁儿童尿路感染伴发热的比例
IF 0.3 Pub Date : 2024-04-15 DOI: 10.4103/jss.jss_265_23
S. Mundada, Ayush Kumar
Fever serves as the most frequent cause of visits to emergency/outpatient pediatric departments among children under the age of five. Very frequently, the youngster is given antibiotics on an arbitrary basis without receiving the proper examination for a urinary tract infection (UTI). This study’s goals were to assess the prevalence of UTIs in febrile children between 6 months and 5 years of age. To study the proportion of UTIs in children between 6 months and 5 years presenting with fever. To study the association of various risk factors with UTI. This Cross-sectional Descriptive observational research was done in the Pediatric department of tertiary care hospital from August 2020 to December 2022, in febrile kids between 6 months and 5 years age group using different variables. Association between two qualitative variables was seen by using Chi-square/Fischer’s exact test. A P < 0.05 was considered statistically significant whereas a P < 0.001 was considered highly significant. Among the total study population, it was found that 5.58% of the patients with fever without focus had a UTI, while the majority of patients, 94.42% did not have a UTI but had fever without a specific focus. In UTI cases, urine culture growth patterns showed the presence of different isolates, including Escherichia coli (30.43%), Klebsiella (56.52%), Pseudomonas aeruginosa (8.7%), and Candida (4.34%). In the present research, the overall occurrence of UTI in children <5 years with fever without focus was 5.58%. Patients with significant pyuria and positive urine culture (UTI) were 43.75% and with significant pyuria but the sterile culture was 56.25%. So, it is concluded that significant pyuria can be sterile pyuria and cannot be labeled as UTI without confirmation on the urine culture report.
发烧是五岁以下儿童到儿科急诊/门诊就诊的最常见原因。很多时候,儿童在没有接受适当的尿路感染(UTI)检查的情况下就被随意使用抗生素。这项研究的目的是评估 6 个月至 5 岁发热儿童中尿路感染的发病率。研究 6 个月至 5 岁发热儿童中尿路感染的比例。研究各种风险因素与尿毒症的关联。 这项横断面描述性观察研究于 2020 年 8 月至 2022 年 12 月在三级医院儿科进行,采用不同变量对 6 个月至 5 岁发热儿童进行研究。两个定性变量之间的关联采用卡方/费舍尔精确检验。P < 0.05 被认为具有统计学意义,而 P < 0.001 则被认为具有高度意义。 研究发现,在所有研究人群中,有 5.58%的发热但无病灶的患者患有尿毒症,而大多数患者(94.42%)没有尿毒症,但有发热但无特定病灶。在 UTI 病例中,尿培养生长模式显示存在不同的分离菌,包括大肠埃希菌(30.43%)、克雷伯菌(56.52%)、铜绿假单胞菌(8.7%)和念珠菌(4.34%)。 在本研究中,5 岁以下儿童发热但无病灶的UTI 总发生率为 5.58%。脓尿明显且尿培养(UTI)阳性的患者占 43.75%,脓尿明显但无菌培养阳性的患者占 56.25%。因此,结论是明显的脓尿可能是无菌性脓尿,在没有尿培养报告确认的情况下,不能将其标注为 UTI。
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引用次数: 0
Renal Manifestation of Mixed Connective Tissue Disease 混合性结缔组织病的肾脏表现
IF 0.3 Pub Date : 2024-03-14 DOI: 10.4103/jss.jss_74_20
Shalini Ashok, Meenakshi Kalyan, Vamsavardhan Reddy, S. Sumangala
A young female presented with facial puffiness and swelling in both lower limbs for 3 months, distension of the abdomen, and breathlessness on exertion for 1 month with a history of hypertension and hypothyroid on regular treatment. On general physical examination, there were pallor, bilateral pitting edema, tachycardia, and blood pressure of 190/100 mmHg. Abdominal examination revealed shifting dullness. Respiratory and cardiovascular systems were normal. Fundoscopy revealed Grade 1 papilledema, and the rest of the neurological examination was unremarkable. Investigations showed normocytic normochromic anemia, serum creatinine of 1.6 mg/dl, and hypoalbuminemia; urine R/E showed significant proteinuria; and anti-U1 ribonucleoprotein particle antibodies were positive. Two-dimensional echocardiography showed mild concentric left ventricular hypertrophy and mild pericardial effusion. Ultrasonography abdomen showed bilateral renal parenchymal disease and moderate ascites. Renal biopsy revealed diffuse proliferative glomerulonephritis and lupus nephritis Class IV. Renal manifestation is very rare in mixed connective tissue disease as an initial presentation
一名年轻女性因面部浮肿、双下肢浮肿 3 个月、腹部胀痛、用力时呼吸困难 1 个月就诊,有高血压和甲状腺功能减退病史,并接受正规治疗。一般体格检查时,患者面色苍白、双侧点状水肿、心动过速,血压为 190/100 mmHg。腹部检查发现腹胀。呼吸和心血管系统正常。眼底镜检查发现 1 级乳头水肿,其他神经系统检查无异常。检查结果显示,患者患有正常红细胞性贫血,血清肌酐为 1.6 毫克/分升,低白蛋白血症;尿液 R/E 显示大量蛋白尿;抗 U1 核糖核蛋白颗粒抗体呈阳性。二维超声心动图显示轻度同心左心室肥厚和轻度心包积液。腹部超声波检查显示双侧肾实质病变和中度腹水。肾活检显示弥漫性增生性肾小球肾炎和狼疮性肾炎 IV 级。在混合性结缔组织病中,以肾脏表现为首发症状非常罕见
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引用次数: 0
The Study of COVID-19 Infection in Health-Care Workers Post-COVID Vaccination 医护人员接种 COVID 疫苗后感染 COVID-19 的研究
IF 0.3 Pub Date : 2024-03-13 DOI: 10.4103/jss.jss_329_22
K. Kinge, Roshni C. Miranda, Priyanka Dnyanoba Chate
Indian Council of Medical Research report in April 2021 showed the incidence of breakthrough infection ranged from 0.02% to 0.04%, in spite of immunization with the COVID vaccine. Hence, the current study was done to find out postvaccination occurrence of COVID-19 in health-care workers (HCWs) and describe the characteristics of postvaccination illness. The objectives of this study were to find out postvaccination COVID-19 illness characteristics such as severity, outcome, and required treatment in HCWs. An analytical cross-sectional study was conducted over the duration of 3 months from July to September 2021 on 988 HCWs. The data were collected using Google Forms made available on social media platforms. Continuous data were analyzed by Mann–Whitney test and categorical variables using the Chi-square test or Fisher’s exact test. Seventy-two (7.2%) out of 988 HCWs that participated in the study were tested COVID-19 positive (56.9% by reverse transcription–polymerase chain reaction, 38.9% by rapid antigen, and 4.16% by CBNAAT) postvaccination. The observed breakthrough infection was 3.84%. There were 18.3% and 5.6% cases of confirmed COVID-19 infection postpartial and complete vaccination, respectively (P = 0.000455). Those HCWs who had direct patient contact i. e., doctors and hospital staff 62 (6.7%) were more infected than other categories of HCWs (P = 0.010). Out of 72 cases who tested positive for COVID-19 infection, 52 were mild, 18 were moderate, and 2 were severe cases. Complete vaccination with two doses of the indigenous COVID vaccine is highly effective to bring down COVID illness-related hospitalization, severity, and death.
印度医学研究委员会 2021 年 4 月的报告显示,尽管接种了 COVID 疫苗,但突破性感染的发生率为 0.02% 至 0.04%。因此,本研究旨在了解医护人员接种 COVID-19 疫苗后的发病情况,并描述接种后疾病的特征。 本研究的目的是了解医护人员接种 COVID-19 疫苗后的疾病特征,如严重程度、结果和所需治疗。 在 2021 年 7 月至 9 月的 3 个月期间,对 988 名医护人员进行了横断面分析研究。数据使用社交媒体平台上提供的谷歌表格收集。连续数据采用曼-惠特尼检验进行分析,分类变量采用卡方检验或费雪精确检验进行分析。 在参与研究的 988 名医务人员中,有 72 人(7.2%)在接种疫苗后被检测出 COVID-19 阳性(56.9% 通过反转录聚合酶链反应检测,38.9% 通过快速抗原检测,4.16% 通过 CBNAAT 检测)。观察到的突破性感染率为 3.84%。接种部分疫苗和完全接种疫苗后分别有 18.3% 和 5.6% 的病例确诊感染 COVID-19(P = 0.000455)。与病人直接接触的医护人员(即医生和医院工作人员)中,62 人(6.7%)的感染率高于其他类别的医护人员(P = 0.010)。在 72 例 COVID-19 感染检测呈阳性的病例中,52 例为轻度感染,18 例为中度感染,2 例为重度感染。 完全接种两剂本土 COVID 疫苗对降低 COVID 相关疾病的住院率、严重程度和死亡率非常有效。
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引用次数: 0
Physical Fitness in Children with Thalassemia Major Measured With 6-min Walk Test 用 6 分钟步行测试测量重型地中海贫血症儿童的体能
IF 0.3 Pub Date : 2024-02-19 DOI: 10.4103/jss.jss_129_23
T. Karthiga, G. Y. Imtiaz, S. Hariharan
Thalassemia major is a common type of genetic disorder found in improvement in the medical field, the life expectancy of these children was also increased so there arises a need to promote the quality of life of such patients. A lot of studies concentrate on various aspects of the life of thalassemia major, but no study was done to assess the physical fitness of such children which is quite important to regularize their exercise sessions. The objective of this study was to find out the physical fitness of children with thalassemia patients. Nonexperimental study designed with 20 individuals diagnosed with thalassemia in major age groups between 7 and 18 both boys and girls. The outcome measure used in this study was 6-min walk test (6 MWT). The mean distance covered in 6 min was 351.3 m on average. There was increase in heart rate and blood pressure after completion of the test, whereas oxygen saturation was found to drop post-6 MWT among these patients. Thalassemia major patients are found with this physical fitness when assessed with 6 MWT.
重型地中海贫血症是一种常见的遗传性疾病,随着医疗水平的提高,这些儿童的预期寿命也有所延长,因此有必要提高这类患者的生活质量。很多研究都集中在重型地中海贫血症患者生活的各个方面,但却没有研究对这些儿童的体能进行评估,而体能对于他们定期锻炼是非常重要的。 本研究旨在了解地中海贫血患儿的体能状况。 这项非实验性研究的对象是 20 名被诊断患有地中海贫血症的儿童,年龄主要集中在 7 到 18 岁之间,包括男孩和女孩。本研究采用的结果测量方法是 6 分钟步行测试(6 MWT)。 6 分钟的平均行走距离为 351.3 米。测试完成后,心率和血压均有所上升,但发现这些患者在 6 分钟步行测试后血氧饱和度有所下降。 地中海贫血症重症患者在进行 6 MWT 评估时,体能状况良好。
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引用次数: 0
A Prospective Observational Study on Drug Utilization in Renal Impaired Patients at Tertiary Care Teaching Hospital 关于三级教学医院肾功能受损患者药物使用情况的前瞻性观察研究
IF 0.3 Pub Date : 2024-01-15 DOI: 10.4103/jss.jss_267_22
Varunsingh Saggu, Dhwani Patel, Cyril Sajan, Hemrajsingh Rajput, Rajesh Hadia
Renal impairment is characterized by a progressive decline in glomerular filtration rate, a significant public health issue worldwide associated with high morbidity and mortality. In most cases, renal impairment is associated with comorbidities such as hypertension and diabetes, which require multiple drug therapy during a course of treatment, leading to polypharmacy. The objective of this study was to assess the prescribing pattern of drugs in renal-impaired patients at Dhiraj General Hospital. A total of 150 patients with renal impairment were finally recruited after strictly obeying the selection criteria in this cross-sectional, observational study conducted over 6 months in a tertiary care teaching hospital, directorate general of hydrocarbons. Relevant data were extracted by interviewing the patients and from prescriptions, case records, and investigational reports. Of the total 150 patients, 94 (63%) were male and 56 (37%) female. The highest numbers of patients were in the age group >60 years (59 patients, 39.3%). Anemia was the most common comorbidity (143 patients, 95%) observed, followed by hypertension (129 patients, 86%) and diabetes mellitus (64 patients, 43%). A total of 1693 drugs were prescribed to 150 renal-impaired patients. Each patient received an average of 11.19 ± 3.51 (8%) drugs. Polypharmacy was seen in all patients. Drugs acting on the cardiovascular system constituted the bulk of the prescriptions (25.87%), followed by gastrointestinal (GI) drugs (18.72%), vitamins and minerals (14.94%), and antibiotics (8.33%). There is polypharmacy in patients with renal impairment due to associated comorbidities. The prevalence of polypharmacy was high in patients with chronic kidney disease (CKD). Antihypertensive drugs, drugs used for the GI system, antibiotics, and antidiabetic drugs were frequently used in CKD patients.
肾功能损害的特征是肾小球滤过率逐渐下降,这是一个与高发病率和高死亡率相关的全球重大公共卫生问题。在大多数情况下,肾功能损害与高血压和糖尿病等合并症有关,在治疗过程中需要多种药物治疗,从而导致多重用药。 本研究旨在评估迪拉吉综合医院肾功能受损患者的处方用药模式。 在这项为期 6 个月的横断面观察性研究中,一家碳氢化合物总局的三级教学医院严格遵守筛选标准,最终招募了 150 名肾功能受损患者。通过与患者面谈以及从处方、病例记录和调查报告中提取相关数据。 在总共 150 名患者中,男性 94 人(占 63%),女性 56 人(占 37%)。年龄大于 60 岁的患者最多(59 人,占 39.3%)。贫血是最常见的合并症(143 名患者,95%),其次是高血压(129 名患者,86%)和糖尿病(64 名患者,43%)。150 名肾功能受损患者共接受了 1693 种药物治疗。每位患者平均服用 11.19 ± 3.51(8%)种药物。所有患者均使用多种药物。心血管系统药物占处方的大部分(25.87%),其次是胃肠道药物(18.72%)、维生素和矿物质(14.94%)以及抗生素(8.33%)。 肾功能损害患者由于伴有合并症,因此会同时使用多种药物。慢性肾脏病(CKD)患者使用多种药物的比例很高。慢性肾脏病患者经常使用抗高血压药物、消化系统药物、抗生素和抗糖尿病药物。
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引用次数: 0
Cerebral venous sinus thrombosis 脑静脉窦血栓形成
IF 0.3 Pub Date : 2023-09-01 DOI: 10.4103/jss.jss_294_22
Cyril Sajan, Varunsingh Saggu, Maitri Mahant, Dilsar Gohel, Foram Bhatt, Elizabeth Jacob
Cerebral venous sinus thrombosis (CVST) is a relatively uncommon but important cause of stroke-like disease, accounting for fewer than 1% of all strokes. CVST is more common in females and infants. CVST patients are most common in the third decade, with a female-to-male ratio of 5:1.5. The incidence of CVST has been found to be high in developing countries, particularly in South-East Asia. Headache is the most prevalent clinical sign of CVST, occurring in 88% to 93% of patients, followed by a seizure in 37% to 71%, focal neurological deficit in 20% to 54%, and isolated increased intracranial pressure in 23%.[1] A 34-year-old male came to the tertiary care hospital with complaints of headache, vomiting, and vertigo for 1 day. Headache is insidious, progressive, nonradiating, holocephalic, severe in intensity and associated with vertigo and dizziness, and giddiness, he also complained about nausea and vomiting (10–12 episodes/day) containing food and water. The patient had no family history but has been chronic tobacco chewer for 10 years. Past medical history revealed that he was admitted to the hospital before for the same complaints and he also had right lower vein deep-vein thrombosis 6 months back. His magnetic imaging resonance reports and protein S and C deficiency reports revealed that he was suffering from CVST. He was prescribed with anticoagulants and other supportive treatments that include antiemetic, analgesics, and multivitamins, which cause faster and better recovery of patients.
脑静脉窦血栓形成(CVST)是中风类疾病中相对少见但却很重要的病因,只占中风总数的不到 1%。CVST 在女性和婴儿中更为常见。CVST 患者多见于第三个十年,男女比例为 5:1.5。在发展中国家,尤其是东南亚,CVST 的发病率很高。头痛是 CVST 最常见的临床表现,88%-93% 的患者会出现头痛,其次是癫痫发作(37%-71%)、局灶性神经功能缺损(20%-54%)和孤立性颅内压增高(23%)。头痛呈隐匿性、进行性、非放射性、全脑性、剧烈,伴有眩晕、头晕和目眩,他还主诉恶心和呕吐(10-12 次/天),呕吐物中含有食物和水。患者没有家族病史,但长期咀嚼烟草已有 10 年之久。既往病史显示,他曾因同样的主诉入院治疗,6 个月前还患过右下静脉深静脉血栓。他的磁共振成像报告以及蛋白质 S 和 C 缺乏症报告显示,他患有 CVST。医生给他开了抗凝剂和其他辅助治疗药物,包括止吐药、镇痛药和多种维生素,这些药物能让患者更快更好地康复。
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引用次数: 0
Training medical students in cognitive, intrapersonal, and interpersonal domain competencies: Existing challenges and role of medical teachers 对医学生进行认知、个人和人际领域能力的培训:现有挑战和医学教师的作用
IF 0.3 Pub Date : 2023-09-01 DOI: 10.4103/jss.jss_178_22
Saurabh Ram Bihari Shrivastava, Mira Duan Raharjo, Bayu Pratama, Tasi'ah Nur, Nurul Maziyyah, K. Pratidina, Achcia Maliny, Yanuarti Retnaningrum
The medical students of the current generation are expected to perform a wide range of activities targeted toward the acquisition of a multitude of skills and the attainment of various learning competencies. The purpose of the current review is to explore the challenges in the cognitive, interpersonal, and intrapersonal domains, and to propose an educational plan to respond to the challenges defined in the cognitive domain. An extensive search of all materials related to the topic was carried out on the PubMed and Google Scholar search engines and a total of 39 articles were selected based on their suitability with the current review objectives. Keywords used in the search include critical thinking and medical education in the title alone only. The findings of a committee reported that a successful health-care professional will essentially require competence in three domains, namely cognitive, intrapersonal, and interpersonal domain. However, the careful analysis of the medical education delivery system across different parts of the world suggests that we are falling short in our efforts to adequately expose medical students' to these competencies. In the global mission to improve the quality of health-care delivery, we have to take specific measures to ensure the attainment of the desired competencies, and the involvement of teachers will be crucial. In conclusion, considering the dynamism in the health sector, it is the responsibility of educators to enhance the attainment of cognitive competencies of the students. Further, students should be encouraged to reflect, and experiential learning should be regularly practiced to equip the students with intrapersonal skills. Finally, we also have to focus on the attainment of interpersonal competencies, as it prepares them to work as effective members of the team.
当代医科学生需要从事各种活动,以掌握多种技能和达到各种学习能力。本综述旨在探讨认知、人际和人内领域的挑战,并提出应对认知领域挑战的教育计划。我们在 PubMed 和谷歌学术搜索引擎上对所有与该主题相关的资料进行了广泛搜索,并根据其与本次综述目标的契合程度共筛选出 39 篇文章。搜索中使用的关键词仅包括标题中的批判性思维和医学教育。一个委员会的研究结果表明,一名成功的医护人员基本上需要具备三个领域的能力,即认知领域、人际领域和个人领域。然而,对世界各地医学教育体系的仔细分析表明,我们在让医学生充分接触这些能力方面做得不够。在提高医疗服务质量的全球任务中,我们必须采取具体措施,确保达到所需的能力,而教师的参与将是至关重要的。总之,考虑到卫生部门的活力,教育工作者有责任提高学生的认知能力。此外,应鼓励学生进行反思,并定期开展体验式学习,以培养学生的个人能力。最后,我们还必须注重培养学生的人际交往能力,因为这有助于他们成为团队中的有效成员。
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引用次数: 0
Newer prospects of regenerative endodontics: A comprehensive and updated review of literature 再生牙髓学的新前景:全面、最新的文献综述
IF 0.3 Pub Date : 2023-09-01 DOI: 10.4103/jss.jss_214_22
M. Khan, M. Jindal
In pediatric dental patients, the management of nonvital immature teeth with undeveloped root in endodontic practice pose difficult and cumbersome clinical situations or challenges for the dental practitioners owing to the various factors, namely, the shorter root with thinner dentinal walls and the lack of apical closure make the affected tooth difficult to obturate conventionally and also make more vulnerable to root fracture. Conventionally, apexification and later apical barrier/plug endodontic modalities have been widely undertaken for such affected teeth. However, such treatment approaches have several intrinsic shortcomings such as uncertain long-term treated tooth prognosis. Since recent years, a biologically based therapeutic endodontic approach known as regenerative endodontic therapy has been or being extensively explored or studied to overcome the drawbacks of previous conventional treatment modalities and also to improve the long-term prognosis of the affected immature nonvital teeth in children and adolescents. Regenerative endodontics is a rapidly evolving subject and also a promising treatment modality for the scientific researchers and clinicians, respectively. Hence, the present article aims to comprehensively and critically appraise the recent literature pertaining to regenerative endodontic procedures. The relevant literature regarding the regenerative endodontics was searched in electronic databases. The articles were retrieved using Boolean operators with relevant keywords/Medical Subject Headings. The included relevant articles were critically appraised in the present review. The latest important aspects of regenerative endodontic have been described in a systematic manner for its better understanding and deeper insights for the general and pediatric dental professionals.
在儿童牙科患者中,牙髓治疗实践中对牙根未发育的非活体未成熟牙齿的管理给牙科医生带来了困难和繁琐的临床情况或挑战,这是由多种因素造成的,即较短的牙根和较薄的牙本质壁以及缺乏根尖封闭使得患牙难以用传统方法封闭,也更容易发生根折。传统上,对这类患牙广泛采用根尖封闭和后来的根尖屏障/根管治疗方法。然而,这些治疗方法都有一些固有的缺陷,比如治疗后牙齿的长期预后不确定。近年来,一种被称为再生牙髓疗法的基于生物学的牙髓治疗方法已经或正在被广泛探索或研究,以克服以往传统治疗方法的弊端,并改善儿童和青少年受影响的未成熟非活髓牙的长期预后。对于科研人员和临床医生来说,再生牙髓学是一个发展迅速的课题,也是一种前景广阔的治疗模式。因此,本文旨在全面、批判性地评估与再生牙髓治疗程序相关的最新文献。本文在电子数据库中搜索了有关再生牙髓术的相关文献。使用布尔运算符和相关关键词/医学主题词检索文章。本综述对收录的相关文章进行了严格评估。本综述系统地描述了再生牙髓学的最新重要方面,以便普通牙科和儿童牙科专业人员更好地理解和深入了解。
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引用次数: 0
Correlation of serum prostate-specific antigen with gleason's score/grade group in prostate cancers and their histopathological findings: A 4-year retrospective study at a tertiary care center 前列腺癌患者血清前列腺特异性抗原与格里森评分/分级组及其组织病理学结果的相关性:一家三级医疗中心的四年回顾性研究
IF 0.3 Pub Date : 2023-09-01 DOI: 10.4103/jss.jss_75_22
Ritu Sharma, Megha Bansal, H. Sharma, Nikhilesh Kumar, Vinish, Monika Gupta, Manju Sirohi
Background: Prostate-specific antigen (PSA) has been widely used as a screening method in different prostatic pathology including prostate cancer. The malignant potential of prostate cancer is associated with tumor volume at diagnosis and studies of the correlation between serum PSA levels and Gleason's grading which remains one of the most powerful predictors of prostate cancer. Aim: To correlate serum PSA and Gleason's score/Group grade in various neoplastic prostatic biopsies and to study their histopathological findings at a tertiary care center. Materials and Methods: This study uses PSA as a screening tool and to correlate serum PSA level to Gleason scores/group grades in various neoplastic and nonneoplastic prostatic biopsies, received at the Department of Pathology, T. S. Misra Medical College and Hospital, Lucknow during 4 years from June 2016 to July 2020. Results: The mean serum PSA value in benign prostatic hyperplasia (BPH) without prostatitis cases was 1.80 ng/ml and BPH with prostatitis was 5.86 and in malignant cases was 55.2 ng/ml. Serum PSA in the range of 0–4 ng/ml was significantly associated with benign lesions and a value of more than 20 ng/ml was significantly associated with malignant lesions. The most frequent Gleason score was 7 and Grade group II was the highest in number. The highest incidence of malignancies and prostatic hyperplasia occurred among the 60–69 years of age group. PSA values increased significantly (P < 0.05) in prostatic carcinoma cases (Group grade II and III). Conclusion: PSA is a valid, sensitive, and early screening method for the diagnosis of both neoplastic and nonneoplastic lesions of the prostate. PSA values correlated significantly with Gleason's score/grade groups of prostatic carcinoma.
背景:前列腺特异性抗原(PSA前列腺特异性抗原(PSA)已被广泛用作包括前列腺癌在内的各种前列腺病理学的筛查方法。前列腺癌的恶性潜能与诊断时的肿瘤体积有关,而血清 PSA 水平与 Gleason 分级之间的相关性研究仍是前列腺癌最有力的预测指标之一。目的:在一家三级医疗中心对各种肿瘤性前列腺活检组织中的血清 PSA 和 Gleason 评分/组分级进行相关性分析,并研究其组织病理学结果。材料和方法:本研究使用 PSA 作为筛查工具,并对勒克瑙 T. S. Misra 医学院和医院病理科在 2016 年 6 月至 2020 年 7 月的 4 年间接收的各种肿瘤性和非肿瘤性前列腺活检组织的血清 PSA 水平与 Gleason 评分/组别等级进行相关性分析。结果:无前列腺炎的良性前列腺增生症(BPH)病例的平均血清 PSA 值为 1.80 纳克/毫升,有前列腺炎的良性前列腺增生症病例的平均血清 PSA 值为 5.86 纳克/毫升,恶性病例的平均血清 PSA 值为 55.2 纳克/毫升。血清 PSA 值在 0-4 纳克/毫升范围内与良性病变明显相关,超过 20 纳克/毫升则与恶性病变明显相关。最常见的 Gleason 评分是 7 分,II 级组数量最多。恶性肿瘤和前列腺增生发病率最高的年龄组为 60-69 岁。前列腺癌病例(II 级和 III 级组)的 PSA 值明显升高(P < 0.05)。结论PSA 是诊断前列腺肿瘤性和非肿瘤性病变的有效、敏感和早期筛查方法。PSA 值与前列腺癌的格里森评分/分级组明显相关。
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