The role of brain perfusion SPECT in the diagnosis of frontotemporal dementia: A systematic review

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2024-01-08 DOI:10.1111/jon.13189

Bruno S. Athanasio, Ana Cecília de Sena Oliveira, Ana Luísa Pedrosa, Rafael S. Borges, Avelar O. M. Neto, Rafael A. Oliveira, Elisa de Paula França de Resende, Renata Freire de Moraes, Paulo Caramelli, Leonardo Cruz de Souza

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Abstract

Background and Purpose

Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. The clinical distinction between FTD, Alzheimer's disease (AD), and other dementias is a clinical challenge. Brain perfusion SPECT may contribute to the diagnosis of FTD, but its value is unclear.

Methods

We performed a systematic review to investigate the diagnostic accuracy of the brain SPECT in (1) distinguishing FTD from AD and other dementias and (2) differentiating FTD variants.

Results

Overall, 391 studies were retrieved on the initial search and 35 studies composed the final selection, comprising a total number of 3142 participants of which 1029 had FTD. The sensitivity and the specificity for the differential diagnosis of FTD versus AD ranged from 56% to 88% and from 51% to 93%, respectively. SPECT is not superior to the clinical method of diagnosis, but the combination of SPECT with clinical data seems to improve the diagnostic accuracy.

Conclusion

Brain perfusion SPECT has a limited value in the diagnostic framework of FTD. SPECT can be performed when FDG-PET is not available. SPECT is recommended only for selected cases when the diagnosis is challenging using conventional methods.

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脑灌注 SPECT 在额颞叶痴呆症诊断中的作用：系统综述。

背景和目的：额颞叶痴呆（FTD）是先证痴呆的第二大常见病因。临床上如何区分 FTD、阿尔茨海默病（AD）和其他痴呆症是一个难题。脑灌注 SPECT 可能有助于 FTD 的诊断，但其价值尚不明确：我们进行了一项系统性综述，研究脑SPECT在以下方面的诊断准确性：（1）区分FTD与AD和其他痴呆症；（2）区分FTD变体：初步检索共检索到 391 项研究，最终筛选出 35 项研究，共有 3142 名参与者，其中 1029 人患有 FTD。鉴别诊断FTD与AD的敏感性和特异性分别为56%至88%和51%至93%。SPECT并不优于临床诊断方法，但将SPECT与临床数据相结合似乎能提高诊断的准确性：结论：脑灌注 SPECT 在 FTD 诊断框架中的价值有限。在没有 FDG-PET 的情况下，可以进行 SPECT。只有在使用传统方法难以诊断的特定病例中，才建议使用SPECT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!