Periodontitis and postoperative inflammation in gastric cancer patients: Propensity score analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-01-15 DOI:10.1111/odi.14865

Mio Sasaki, Hideo Shigeishi, Hiromi Nishi, Natsuki Hamada, Honami Kitasaki, Kanako Yano, Yoshino Kaneyasu, Susumu Horikoshi, Hiroyuki Kawaguchi, Kouji Ohta

{"title":"Periodontitis and postoperative inflammation in gastric cancer patients: Propensity score analysis.","authors":"Mio Sasaki, Hideo Shigeishi, Hiromi Nishi, Natsuki Hamada, Honami Kitasaki, Kanako Yano, Yoshino Kaneyasu, Susumu Horikoshi, Hiroyuki Kawaguchi, Kouji Ohta","doi":"10.1111/odi.14865","DOIUrl":null,"url":null,"abstract":"Objective: The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer.Subjects and methods: This retrospective cohort study analyzed data from 140 gastric cancer patients who underwent surgery at Hiroshima University Hospital between May 2019 and May 2022. Periodontal inflamed surface area (PISA) scores were determined to assess periodontitis severity using modified Nesse's methods. Propensity score matching was used to compare patients with high and low PISA scores (> or < the median PISA score of 92.4, respectively). Propensity scores were calculated using a logistic regression model, based on 17 clinical parameters: age, sex, smoking, alcohol consumption, hypertension, diabetes, dyslipidemia, cardiovascular disease, stroke, clinical stage, surgical procedure, surgical approach, neoadjuvant chemotherapy, surgery duration, blood loss during surgery, remaining teeth, and denture use.Results: Thirty-seven patients were propensity-score-matched. Participants with high PISA scores had a higher incidence of surgical site infection (10.5%) than those with low PISA scores (5.3%). Moreover, participants with high PISA scores had significantly higher C-reactive protein levels on postoperative days 1 than those with low PISA scores.Conclusion: Preoperative periodontitis may determine the level of postoperative systemic inflammation in patients with gastric cancer.","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.14865","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer.

Subjects and methods: This retrospective cohort study analyzed data from 140 gastric cancer patients who underwent surgery at Hiroshima University Hospital between May 2019 and May 2022. Periodontal inflamed surface area (PISA) scores were determined to assess periodontitis severity using modified Nesse's methods. Propensity score matching was used to compare patients with high and low PISA scores (> or < the median PISA score of 92.4, respectively). Propensity scores were calculated using a logistic regression model, based on 17 clinical parameters: age, sex, smoking, alcohol consumption, hypertension, diabetes, dyslipidemia, cardiovascular disease, stroke, clinical stage, surgical procedure, surgical approach, neoadjuvant chemotherapy, surgery duration, blood loss during surgery, remaining teeth, and denture use.

Results: Thirty-seven patients were propensity-score-matched. Participants with high PISA scores had a higher incidence of surgical site infection (10.5%) than those with low PISA scores (5.3%). Moreover, participants with high PISA scores had significantly higher C-reactive protein levels on postoperative days 1 than those with low PISA scores.

Conclusion: Preoperative periodontitis may determine the level of postoperative systemic inflammation in patients with gastric cancer.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胃癌患者的牙周炎和术后炎症：倾向得分分析

研究目的本研究旨在明确胃癌患者术前牙周炎与术后全身炎症之间的关系：这项回顾性队列研究分析了2019年5月至2022年5月期间在广岛大学医院接受手术的140名胃癌患者的数据。采用改良内塞法确定牙周炎症表面积（PISA）评分，以评估牙周炎的严重程度。采用倾向得分匹配法比较 PISA 得分高和低的患者（分别大于或小于 PISA 中位数 92.4 分）。采用逻辑回归模型计算倾向得分，该模型基于 17 项临床参数：年龄、性别、吸烟、饮酒、高血压、糖尿病、血脂异常、心血管疾病、中风、临床分期、手术方式、手术方法、新辅助化疗、手术持续时间、手术失血量、剩余牙齿和义齿使用情况：37名患者进行了倾向评分匹配。PISA得分高的患者手术部位感染发生率（10.5%）高于PISA得分低的患者（5.3%）。此外，PISA评分高的患者术后第1天的C反应蛋白水平明显高于PISA评分低的患者：结论：术前牙周炎可能决定胃癌患者术后全身炎症的程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.