Recent advances in the epithelial barrier theory.

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2024-04-03 DOI:10.1093/intimm/dxae002
Yagiz Pat, Duygu Yazici, Paolo D'Avino, Manru Li, Sena Ardicli, Ozge Ardicli, Yasutaka Mitamura, Mübeccel Akdis, Raja Dhir, Kari Nadeau, Ioana Agache, Ismail Ogulur, Cezmi A Akdis
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Abstract

The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, and industrialization, affecting human health. Introducing new chemicals without any reasonable control of their health effects through these years has led to documented adverse effects, especially on the skin and mucosal epithelial barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- and nano-plastics, diesel exhaust, cigarette smoke, and ozone, have been shown to compromise the epithelial barrier integrity. This disruption is linked to the opening of the tight-junction barriers, inflammation, cell death, oxidative stress, and metabolic regulation. Consideration must be given to the interplay of toxic substances, underlying inflammatory diseases, and medications, especially in affected tissues. This review article discusses the detrimental effect of environmental barrier-damaging compounds on human health and involves cellular and molecular mechanisms.

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上皮屏障理论的最新进展。
上皮屏障理论认为,近年来慢性非传染性疾病(尤其是自身免疫性和过敏性疾病)的增加与破坏上皮屏障的环境因素有关。六十多年来,由于无节制的增长、现代化和工业化,全球污染和环境有毒物质暴露日益严重,影响了人类健康。这些年来,在没有对新化学物质的健康影响进行合理控制的情况下引入这些物质,导致了有记录的不良影响,尤其是对皮肤和粘膜上皮屏障的影响。这些物质,如微粒物质、洗涤剂、表面活性剂、食品乳化剂、微塑料和纳米塑料、柴油废气、香烟烟雾和臭氧,已被证明会损害上皮屏障的完整性。这种破坏与紧密连接屏障的开放、炎症、细胞死亡、氧化应激和代谢调节有关。必须考虑有毒物质、潜在炎症疾病和药物的相互作用,尤其是在受影响的组织中。这篇综述文章讨论了破坏环境屏障的化合物对人体健康的有害影响,并涉及细胞和分子机制。
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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
期刊最新文献
Dysfunction of type 1 and type 2 immune cells: a lesson from exhausted-like ILC2s and their activation-induced cell death. The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset? The role of dendritic cells in the instruction of helper T cells in the allergic march. Ro5-4864, a translocator protein ligand, regulates T cell-mediated inflammatory responses in skin. JunB is required for CD8+ T cell responses to acute infections.
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