Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients.

IF 2 4区医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI:10.1159/000535900

Hui Xiao, Yuan Liu, Ni Guo, Ling Jin, Zhenyu Wang, Shufen Lin, Yixiu Lin, Shaoyang Zheng, Yuheng Tan, Nachuan Luo, Xing Liu, Chengguo Zuo

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Abstract

Introduction: This study investigated the clinical characteristics of and risk factors for microcystic macular edema (MME) in patients with chronic primary angle-closure glaucoma (CPACG) and primary open-angle glaucoma (POAG).

Methods: This retrospective observational study included 1,588 eyes from 926 glaucoma inpatients and analyzed the patients' basic demographic information, visual field parameters, macular scans, and peripapillary retinal nerve fiber layer thickness.

Results: Our findings were that the incidence rate of MME was 3.97% (34/857) in CPACG and 5.88% (43/731) in POAG. MME was predominantly diagnosed at an advanced stage in CPACG (almost 100%) compared to POAG (93.02%). MME was most frequently involved in the inferior (83.12%) quadrant of the peri-macular region in both CPACG and POAG. Risk factors for MME occurrence in CPACG and POAG included lower visual field mean deviation (OR = 1.14, 95%: CI 1.05-1.24, p = 0.003; OR = 1.14, 95% CI: 1.06-1.21, p < 0.001) and younger age (OR = 0.92, 95% CI: 0.88-0.96, p < 0.001; OR = 0.96, 95% CI: 0.93-0.99, p = 0.003), while female sex (OR = 0.30, 95% CI: 0.11-0.84, p = 0.022) reduced the MME occurrence in POAG.

Conclusion: MME could develop in both CPACG and POAG patients, occurring earlier in POAG. The inferior peri-macular region is commonly affected. Younger age and poorer visual field are risk factors for MME in glaucoma patients.

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慢性原发性闭角型青光眼和原发性开角型青光眼患者微囊性黄斑水肿的临床特征。

导言：本研究调查了慢性原发性闭角型青光眼（CPACG）和原发性开角型青光眼（POAG）患者微囊性黄斑水肿（MME）的临床特征和风险因素：这项回顾性观察研究纳入了926名青光眼住院患者的1588只眼睛，分析了患者的基本人口学信息、视野参数、黄斑扫描和毛细血管周围视网膜神经纤维层厚度：我们的研究结果表明，CPACG 患者的 MME 发病率为 3.97%（34/857），POAG 患者的 MME 发病率为 5.88%（43/731）。与 POAG（93.08%）相比，MME 在 CPACG（几乎 100%）中主要诊断为晚期。在 CPACG 和 POAG 中，MME 最常累及黄斑周围的下象限（83.12%）。CPACG和POAG发生MME的危险因素包括视野平均偏差（MD）较低（OR=1.14，95% CI：1.06-1.21，P< 0.001）和年龄较小（OR=0.96，95% CI：0.93-0.99，P= 0.003），而女性（OR=0.30，95% CI：0.11-0.84，P= 0.022）会降低POAG的MME发生率：结论：CPACG 和 POAG 患者都可能发生 MME，POAG 患者的发生率更高。下黄斑周围区域常受影响。年龄较小和视野较差是青光眼患者发生 MME 的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.