Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review.

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0113895575277085231123165546
Wen-Zhe Nie, Qing-Kun Shen, Zhe-Shan Quan, Hong-Yan Guo, Ya-Mei Li
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Abstract

Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structural modification, biological activity and structure-activity relationship of usnic acid were reviewed to provide reference for the development of usnic acid derivatives.

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松萝酸衍生物的生物活性和结构-活性关系:综述。
鸟苷酸具有多种生物活性,在抗菌、免疫刺激、抗病毒、抗真菌、抗炎和抗寄生虫等领域被广泛研究。在此基础上,人们将 usnic 酸作为结构修饰的先导化合物。为了提高烟酸的生物活性和溶解性,学者们进行了大量的结构修饰,发现一些烟酸衍生物更具有潜在的研究价值。本文综述了烟酸的结构修饰、生物活性和构效关系,为烟酸衍生物的开发提供参考。
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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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