Lipid index to quantify the absorbed lipids in retrieved UHMWPE components of joint arthroplasty

IF 1 4区医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-24 DOI:10.3233/bme-230183

Hideyuki Sakoda, Yusuke Tsuboko, Yoshihiro Okamoto, Eiichi Yamamoto, Takashi Imagama, Takashi Sakai, Hidetoshi Hamada, Nobuhiko Sugano

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Abstract

BACKGROUND:The ultra-high molecular weight polyethylene (UHMWPE) component of artificial joints is one of the most important factors affecting the clinical outcomes of joint arthroplasty. Although the possibility of in vivo UHMWPE degradation caused by absorbed lipids has been reported, a quantitative evaluation of this phenomenon has not yet been performed. OBJECTIVE:This study aimed to establish the lipid index (LI) as a quantitative indicator of the amount of absorbed lipids and the first step to quantify their effects on UHMWPE. METHODS:The LI was defined using the infrared spectrum obtained with a Fourier-transform infrared spectrophotometer and verified using the retrieved UHMWPE components. RESULTS:The LI was consistent with the amount of extract recovered in reflux extraction with hexane. In addition, the LI could replace lipid extraction for calculating the oxidation index (OI) because the value obtained by subtracting the LI from the OI showed good agreement with the OI obtained after lipid extraction. CONCLUSION:The LI represents the amount of lipids absorbed by UHMWPE and is useful for quantitatively evaluating the effects of lipids on UHMWPE. In addition, the LI enables OI measurements that are unaffected by absorbed lipids without requiring troublesome lipid-extraction procedures.

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用于量化关节成形术中超高分子量聚乙烯回收组件中吸收的脂质的脂质指数

背景：人工关节的超高分子量聚乙烯（UHMWPE）组件是影响关节置换术临床效果的最重要因素之一。虽然有报道称吸收的脂质可能导致体内超高分子量聚乙烯降解，但尚未对这一现象进行定量评估。目的：本研究旨在确定脂质指数（LI），作为吸收脂质量的定量指标和量化脂质对超高分子量聚乙烯影响的第一步。方法：使用傅立叶变换红外分光光度计获得的红外光谱来定义脂质指数，并使用回收的超高分子量聚乙烯成分进行验证。结果：LI 与正己烷回流提取中回收的提取物量一致。此外，LI 可以代替脂质萃取来计算氧化指数（OI），因为从 OI 中减去 LI 后得到的值与脂质萃取后得到的 OI 非常一致。结论：LI 表示超高分子量聚乙烯吸收的脂质量，有助于定量评估脂质对超高分子量聚乙烯的影响。此外，LI 还能测量不受吸收脂质影响的 OI，而无需麻烦的脂质提取程序。

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来源期刊

Bio-medical materials and engineering 工程技术-材料科学：生物材料

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.