Potential Antiviral Effect of Korean Forest Wild Mushrooms Against Feline Coronavirus (FCoV)

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-01-01 DOI:10.1615/intjmedmushrooms.2024052483
Rhim Ryoo, Hyorim Lee, Youngki Park
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Abstract

Coronaviruses (CoV), are among the major viruses causing the common cold in humans. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is high-risk human pathogens that derived from bat coronaviruses, although several other animals serve as CoV hosts, contributing to human infection. As the human activity area expanded, viruses previously prevalent only in animals mutated and became threats to humans as well, leading to worldwide epidemics. Therefore, controlling CoV infections in animals is essential to prevent CoV-related human infections. Feline coronavirus (FCoV) could be reportedly used as an alternative model for SARS-CoV-2. Traditionally, mushrooms are not only foods but are also consumed to prevent diseases. Importantly, certain edible and medicinal mushrooms display antibacterial and antiviral effects against respiratory pathogens, they could thus be tested as potential coronavirus treatment agents. Therefore, in this study, we investigated if wild forest mushrooms with various, reported physiological activities could exhibit an antiviral activity against CoV, using FCoV as a SARS-CoV-2 model infecting Crandell Rees Feline Kidney cells. We measured the antiviral activity of overall 11 wild mushrooms and our results demonstrated that Pleurotus ostreatus and Phallus luteus displayed the highest antiviral efficacy of 55.33%, followed by Tricholoma bakamatsutake at 43.77%. Grifola frondosa, Morchella esculenta, and Sarcodon imbricatus exhibited mild efficacy of 29.21%; We also tested Amanita caesareoides, Marasmius siccus, Pachyma hoelen, Phallus rubrovolvata, and Sparassis latifolia but could not detect any antiviral activity in their case. Our study confi
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韩国森林野生蘑菇对猫冠状病毒(FCoV)的潜在抗病毒作用
冠状病毒(CoV)是引起人类普通感冒的主要病毒之一。严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)是源自蝙蝠冠状病毒的高危人类病原体,尽管其他几种动物也是冠状病毒的宿主,也会造成人类感染。随着人类活动范围的扩大,以前只在动物中流行的病毒发生了变异,对人类也构成了威胁,导致了全球性的流行病。因此,控制动物中的 CoV 感染对于预防与 CoV 相关的人类感染至关重要。据报道,猫冠状病毒(FCoV)可作为 SARS-CoV-2 的替代模型。传统上,蘑菇不仅是食物,还可以用来预防疾病。重要的是,某些食用和药用蘑菇对呼吸道病原体有抗菌和抗病毒作用,因此可以作为潜在的冠状病毒治疗药物进行试验。因此,在本研究中,我们以感染 Crandell Rees 猫肾细胞的 FCoV 作为 SARS-CoV-2 模型,研究了具有各种生理活性的森林野生蘑菇是否具有抗 CoV 病毒的活性。我们对 11 种野生蘑菇的抗病毒活性进行了测定,结果表明牛肝菌(Pleurotus ostreatus)和牛肝菌(Phallus luteus)的抗病毒效力最高,为 55.33%,其次是白蘑(Tricholoma bakamatsutake),为 43.77%。我们还测试了 Amanita caesareoides、Marasmius siccus、Pachyma hoelen、Phallus rubrovolvata 和 Sparassis latifolia,但没有检测到任何抗病毒活性。我们的研究证实
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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