Comparative Analysis of Direct Cold Atmospheric Plasma Treatment vs. Plasma Activated Water for the Deactivation of Omicron Variant of SARS-CoV-2

IF 2.6 3区物理与天体物理 Q3 ENGINEERING, CHEMICAL Plasma Chemistry and Plasma Processing Pub Date : 2024-01-28 DOI:10.1007/s11090-024-10449-9

Reema, Deepjyoti Basumatary, Heremba Bailung, Kamatchi Sankaranarayanan

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Abstract

Cold atmospheric plasma (CAP) has gaining potential, and very effective to curb or deactivate the various microorganisms such as bacteria and virus. Lately, the major outbreak SARS-CoV-2 infection has affected humanity largely with added complexity of its ability to mutate to variants such as Omicron. We have earlier shown the effectiveness of CAP on SARS-CoV-2 spike protein and, in this study, we have evaluated the effectiveness of CAP to deactivate Omicron. We studied the ability of the binding of Angiotensin converting Enzyme Protein (ACE2) protein to the plasma treated spike S1-S2 protein and spike Receptor binding domain (RBD) using Cold atmospheric plasma direct treatment as well as Plasma activated water (PAW). Results have shown the binding efficiency of Omicron spike protein to ACE2 decrease with increase in treatment time with both direct treatment and PAW as evidenced using spectroscopic techniques. The reactive species (RONS) play a major role in the efficient deactivation of the binding of ACE2 to the Omicron spike protein. Correspondingly, the comparison between the efficiency between direct treatment and PAW has also been discussed.

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直接冷大气等离子处理与等离子活化水在灭活 SARS-CoV-2 奥米克龙变异体方面的比较分析

冷大气等离子体（CAP）具有越来越大的潜力，在抑制或灭活细菌和病毒等各种微生物方面非常有效。最近，大规模爆发的 SARS-CoV-2 感染在很大程度上影响了人类，其变异能力（如 Omicron）也增加了复杂性。我们早些时候已经证明了 CAP 对 SARS-CoV-2 尖峰蛋白的有效性，在本研究中，我们评估了 CAP 对 Omicron 失活的有效性。我们使用冷大气等离子体直接处理法和等离子体活化水（PAW）研究了血管紧张素转换酶蛋白（ACE2）与等离子体处理过的尖峰 S1-S2 蛋白和尖峰受体结合域（RBD）的结合能力。结果表明，无论是直接处理还是等离子活化水处理，随着处理时间的延长，奥米克龙穗蛋白与 ACE2 的结合效率都会降低，这一点可以通过光谱技术得到证明。活性物种（RONS）在有效失活 ACE2 与 Omicron spike 蛋白的结合中发挥了重要作用。相应地，我们还讨论了直接处理和 PAW 的效率比较。

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来源期刊

Plasma Chemistry and Plasma Processing 工程技术-工程：化工

CiteScore

5.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Publishing original papers on fundamental and applied research in plasma chemistry and plasma processing, the scope of this journal includes processing plasmas ranging from non-thermal plasmas to thermal plasmas, and fundamental plasma studies as well as studies of specific plasma applications. Such applications include but are not limited to plasma catalysis, environmental processing including treatment of liquids and gases, biological applications of plasmas including plasma medicine and agriculture, surface modification and deposition, powder and nanostructure synthesis, energy applications including plasma combustion and reforming, resource recovery, coupling of plasmas and electrochemistry, and plasma etching. Studies of chemical kinetics in plasmas, and the interactions of plasmas with surfaces are also solicited. It is essential that submissions include substantial consideration of the role of the plasma, for example, the relevant plasma chemistry, plasma physics or plasma–surface interactions; manuscripts that consider solely the properties of materials or substances processed using a plasma are not within the journal’s scope.