Allogenic Simple Limbal Epithelial Transplantation: An Approach to Bilateral Recurrent Pterygia and Limbal Stem Cell Deficiency

Shefali Mazumdar, Samya Singh, Nandini Asija, Lavi Madhur
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Abstract

A 44-year-old man presented with bilateral total limbal stem cell deficiency after multiple failed surgeries for recurrent pterygia in both eyes over the last 11 years. His best corrected visual acuity (BCVA) in both eyes at the time of presentation was hand movement, projection of rays accurate. Owing to bilateral involvement, allogenic simple limbal epithelial transplantation (Allo SLET) was performed in the right eye. The limbal biopsy was taken from the wife of the patient. Complete ocular surface epithelialization was achieved in 26 days. The patient has completed 15 months of postoperative follow-up with stable ocular surface and BCVA 6/12 in the RE. He is on systemic and topical immunosuppressants with no side effects to date.
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异基因单纯睑缘上皮移植:治疗双侧复发性翼状胬肉和角膜干细胞缺乏症的方法
一名 44 岁的男子在过去 11 年中因双眼复发性翼状胬肉进行了多次手术,但均以失败告终。就诊时,他双眼的最佳矫正视力(BCVA)为手能动,光线投射准确。由于双侧受累,他的右眼接受了异基因单纯角膜缘上皮移植术(Allo SLET)。眼睑缘活检取自患者的妻子。眼表上皮在 26 天内完全上皮化。患者术后随访 15 个月,眼表稳定,RE 的 BCVA 为 6/12。他一直在使用全身和局部免疫抑制剂,至今没有出现副作用。
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