ADR assessment of isoniazid induced psychosis: Case report and review of literature

K. K. Kurup, KP Shamabanu, NK Khadeejathul Nifana Nasrin, MM Hafshath, Muhammed Sinan Abdul Karim
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Abstract

Tuberculosis ranks among the top 10 causes of death globally and stands as the primary cause attributed to a single infectious agent. Among all antitubercular drugs, Isoniazid is most important role in the management of pulmonary tuberculosis.Various neuropsychiatric adverse effects have been documented in association with the use of isoniazid, both in therapeutic and overdose scenarios. This case report describes a 68-year-old male with multiple health issues, including disseminated tuberculosis, developed drug-induced psychosis, likely due to isoniazid in his anti-tubercular therapy. This case underscores the challenges of psychiatric adverse effects in tuberculosis treatment and emphasizes the importance of prompt recognition and intervention.
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异烟肼诱发精神病的 ADR 评估:病例报告和文献综述
结核病是全球十大死因之一,也是由单一传染源引起的主要死因。在所有抗结核药物中,异烟肼在肺结核的治疗中扮演着最重要的角色。有记录显示,在治疗和过量使用异烟肼的情况下,会出现各种神经精神方面的不良反应。本病例报告描述了一名 68 岁的男性患者,他有多种健康问题,包括播散性肺结核,但却出现了药物性精神病,这很可能是由于他在抗结核治疗中使用了异烟肼。本病例强调了结核病治疗中精神疾病不良反应所带来的挑战,并强调了及时识别和干预的重要性。
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