Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.001
Suryakanta Swain, Debashsish Ghose
{"title":"4D printing and its potential applications in the healthcare sector","authors":"Suryakanta Swain, Debashsish Ghose","doi":"10.18231/j.ijpp.2024.001","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.001","url":null,"abstract":"","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"10 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the prescribing pattern of use of PPI with respect to “FDA-Approved Indications and Doses for PPI Therapy.” Materials and Methods: After obtaining approval from the Institutional Ethics Committee, a cross-sectional study was carried out among 400 inpatients in a tertiary care hospital in Bangalore. The data were collected from the patient case profile and prescriptions and noted in a self-designed data collection form. The statistical analysis of the collected data was performed using SPSS software and Excel. Results: The study, conducted on 400 patients, revealed a male majority (60%) and a female representation of 40%. Proton Pump Inhibitors (PPIs), mainly Pantoprazole (74.70%), were frequently prescribed, notably in General Medicine (220 patients). PPI use was generally appropriate: indication (99%), dose (97%), frequency (92.8%), and duration (91.8%). However, irrational prescriptions were noted: indication (1%), dose (3%), frequency (7.3%), and duration (8.3%). 139 drug interactions were identified, categorized into Major (39.6%), Moderate (46%), and Minor (14.4%). For example, Ondansetron and tramadol exhibited a major interaction. Among PPI combinations, 93.75% could affect CYP2C19 metabolism, and 6.3% had additive/synergistic toxicity potential.
目的分析根据 "FDA 批准的 PPI 治疗适应症和剂量 "使用 PPI 的处方模式。材料与方法：在获得机构伦理委员会批准后，对班加罗尔一家三级医院的 400 名住院患者进行了横断面研究。研究人员从患者病例和处方中收集数据，并在自行设计的数据收集表中进行记录。使用 SPSS 软件和 Excel 对收集到的数据进行了统计分析。研究结果对 400 名患者进行的研究显示，男性占多数（60%），女性占 40%。质子泵抑制剂（PPI），主要是泮托拉唑（74.70%），是常用处方药，尤其是在全科（220 名患者）中。一般来说，PPI 的使用是适当的：适应症（99%）、剂量（97%）、频率（92.8%）和持续时间（91.8%）。但也有不合理的处方：适应症（1%）、剂量（3%）、频率（7.3%）和持续时间（8.3%）。共发现 139 种药物相互作用，分为严重（39.6%）、中度（46%）和轻微（14.4%）。例如，昂丹司琼与曲马多发生了严重相互作用。在 PPI 联合用药中，93.75% 的药物会影响 CYP2C19 的代谢，6.3% 的药物可能具有相加/协同毒性。
{"title":"A study on appropriate use and stewardship of proton pump inhibitors","authors":"Naresh Mondal, Shilpi Maity, Alamki Phawa, Bireswar Roy, E. Satheesh Kumar, Narayana Swamy V.B","doi":"10.18231/j.ijpp.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.010","url":null,"abstract":"Objective: To analyze the prescribing pattern of use of PPI with respect to “FDA-Approved Indications and Doses for PPI Therapy.” Materials and Methods: After obtaining approval from the Institutional Ethics Committee, a cross-sectional study was carried out among 400 inpatients in a tertiary care hospital in Bangalore. The data were collected from the patient case profile and prescriptions and noted in a self-designed data collection form. The statistical analysis of the collected data was performed using SPSS software and Excel. Results: The study, conducted on 400 patients, revealed a male majority (60%) and a female representation of 40%. Proton Pump Inhibitors (PPIs), mainly Pantoprazole (74.70%), were frequently prescribed, notably in General Medicine (220 patients). PPI use was generally appropriate: indication (99%), dose (97%), frequency (92.8%), and duration (91.8%). However, irrational prescriptions were noted: indication (1%), dose (3%), frequency (7.3%), and duration (8.3%). 139 drug interactions were identified, categorized into Major (39.6%), Moderate (46%), and Minor (14.4%). For example, Ondansetron and tramadol exhibited a major interaction. Among PPI combinations, 93.75% could affect CYP2C19 metabolism, and 6.3% had additive/synergistic toxicity potential.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"41 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.009
M. Khalse, Kamlesh Patel, Varsha Pawar
Azole antifungal agents are effective agents for treating scalp ailments such as seborrheic dermatitis. Luliconazole (LZ) is a new azole with unique effects against clinically important dermatomycotic fungi. This study examines the impact of different topical formulation of Luliconazole vs Ketoconazole (KZ) on damaged hair cuticle repair after 5 and 10 washes, using SEM images and sensory Analysis.In this in-vitro study,twelve damaged hair tresses were divided into two groups, and treated with LZ and KZ formulations. Both groups underwent pretreatment with 20% Sodium Laureth sulfate (SLES) and damage induction using 9% HO and 20% ammonium solution, followed by respective LZ (Lupizol ZS, manufactured by Lupin Ltd, India) and KZ therapies. SEM imaging and expert sensory analysis were conducted at baseline, after 5, and 10 washes to evaluate surface characterization like cuticle upliftment, smoothness, and softness.After five washes, LZ-treated hair exhibited smooth, intact cuticles with no upliftment, improving to grade 1 cuticle damage. In contrast, KZ-treated hair continued to show substantial upliftment without damage grade improvement. After ten washes, LZ maintained grade 1 damage and 0 µm upliftment, while KZ-treated strands persisted in showing considerable cuticular distress. Sensory analysis supported these results, with LZ improving hair smoothness and softness by 2.42x and 2.72x respectively, after ten washes, significantly outperforming KZ. Visually, LZ-treated hair appeared smoother and healthier, indicating its greater effectiveness in enhancing hair integrity post-washing.The botanical conditioner-based formulation of LZ is more efficacious in enhancing hair integrity post-washing compared to the Ketoconazole formulation. Well-controlled human studies are required to further establish the clinical effects on human participants.
{"title":"Effectiveness of luliconazole vs ketoconazole topical formulation in reversing damaged hair cuticle","authors":"M. Khalse, Kamlesh Patel, Varsha Pawar","doi":"10.18231/j.ijpp.2024.009","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.009","url":null,"abstract":"Azole antifungal agents are effective agents for treating scalp ailments such as seborrheic dermatitis. Luliconazole (LZ) is a new azole with unique effects against clinically important dermatomycotic fungi. This study examines the impact of different topical formulation of Luliconazole vs Ketoconazole (KZ) on damaged hair cuticle repair after 5 and 10 washes, using SEM images and sensory Analysis.In this in-vitro study,twelve damaged hair tresses were divided into two groups, and treated with LZ and KZ formulations. Both groups underwent pretreatment with 20% Sodium Laureth sulfate (SLES) and damage induction using 9% HO and 20% ammonium solution, followed by respective LZ (Lupizol ZS, manufactured by Lupin Ltd, India) and KZ therapies. SEM imaging and expert sensory analysis were conducted at baseline, after 5, and 10 washes to evaluate surface characterization like cuticle upliftment, smoothness, and softness.After five washes, LZ-treated hair exhibited smooth, intact cuticles with no upliftment, improving to grade 1 cuticle damage. In contrast, KZ-treated hair continued to show substantial upliftment without damage grade improvement. After ten washes, LZ maintained grade 1 damage and 0 µm upliftment, while KZ-treated strands persisted in showing considerable cuticular distress. Sensory analysis supported these results, with LZ improving hair smoothness and softness by 2.42x and 2.72x respectively, after ten washes, significantly outperforming KZ. Visually, LZ-treated hair appeared smoother and healthier, indicating its greater effectiveness in enhancing hair integrity post-washing.The botanical conditioner-based formulation of LZ is more efficacious in enhancing hair integrity post-washing compared to the Ketoconazole formulation. Well-controlled human studies are required to further establish the clinical effects on human participants.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.002
Abid Ali Sheikh, M. Makhdoomi, Abid Hussain Rather, T. A. Lone, Nisar Ahmad Syed
Thyroid cancer stands as the predominant malignancy within the endocrine system, comprising about 1% of newly identified cancer instances. Papillary Thyroid Cancer (PTC) is the predominant form of thyroid cancer, representing 80% or more of thyroid malignancies. Thyroid carcinoma harbours assorted genetic alterations which are highly prevalent, several of these characteristics are unique to this form of cancer. The conventional oncogenic genetic modifications frequently observed in thyroid carcinoma encompass RAS mutations RET/PTC rearrangements and PAX8-peroxisome proliferator-activated receptor g (PPARg) fusion oncogene. The lately discovered activating mutation in BRAF (the gene for the B-type RAF kinase, BRAF) the most widespread genetic modification in thyroid cancer (30-83%). RKIP (RAF kinase inhibitory protein) had formerly been delineated as a phospholipid binding protein. Mammalian RKIP/PEBP differs from other identified proteins and its role is still being clarified. RKIP over-expression can inhibit MEK interaction with RAF-1 and B-RAF. It plays a role in thyroid cancer progression and lymph node metastasis. So, elucidating mutational profile and protein expression of above cell signalling molecules will be very useful in determining a proper therapeutic target for anti-cancer molecules. Given that tumors often possess numerous genetic and cell signalling abnormalities, thus inhibiting a single signalling pathway is often therapeutically inefficacious, more success could be foreseen with agents directed against multiple cellular pathways.By determining the genetic profile and protein expression of mentioned MAP Kinase pathway molecules new targets can be identified for chemotherapic drugs and novel strategies will be charted out to make modifications in the map kinase pathway with the aim to stop the occurrence and distant metastasis of thyroid cancer.
{"title":"Papillary thyroid cancer and its gene polymorphism; A molecular mechanistic perspective","authors":"Abid Ali Sheikh, M. Makhdoomi, Abid Hussain Rather, T. A. Lone, Nisar Ahmad Syed","doi":"10.18231/j.ijpp.2024.002","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.002","url":null,"abstract":"Thyroid cancer stands as the predominant malignancy within the endocrine system, comprising about 1% of newly identified cancer instances. Papillary Thyroid Cancer (PTC) is the predominant form of thyroid cancer, representing 80% or more of thyroid malignancies. Thyroid carcinoma harbours assorted genetic alterations which are highly prevalent, several of these characteristics are unique to this form of cancer. The conventional oncogenic genetic modifications frequently observed in thyroid carcinoma encompass RAS mutations RET/PTC rearrangements and PAX8-peroxisome proliferator-activated receptor g (PPARg) fusion oncogene. The lately discovered activating mutation in BRAF (the gene for the B-type RAF kinase, BRAF) the most widespread genetic modification in thyroid cancer (30-83%). RKIP (RAF kinase inhibitory protein) had formerly been delineated as a phospholipid binding protein. Mammalian RKIP/PEBP differs from other identified proteins and its role is still being clarified. RKIP over-expression can inhibit MEK interaction with RAF-1 and B-RAF. It plays a role in thyroid cancer progression and lymph node metastasis. So, elucidating mutational profile and protein expression of above cell signalling molecules will be very useful in determining a proper therapeutic target for anti-cancer molecules. Given that tumors often possess numerous genetic and cell signalling abnormalities, thus inhibiting a single signalling pathway is often therapeutically inefficacious, more success could be foreseen with agents directed against multiple cellular pathways.By determining the genetic profile and protein expression of mentioned MAP Kinase pathway molecules new targets can be identified for chemotherapic drugs and novel strategies will be charted out to make modifications in the map kinase pathway with the aim to stop the occurrence and distant metastasis of thyroid cancer.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"55 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.003
Prakash Raj K, Rajakarthikeyan U, Saranraj L, Sivakumar L, R. Yuvhraj, Buvaneshvaran K
Transdermal drug delivery devices (TDDS), often known as "patches," are dosage forms designed to transfer a therapeutically effective amount of medicine over a patient's skin. Transdermal distribution establishes one of the most important channels for a revolutionary medication delivery method. Transdermal drug delivery has various advantages over traditional delivery methods, such as oral and injection; however, its efficacy is restricted. Transdermal administration traditionally entails pushing a patch containing a medicinal substance onto the skin, which is both convenient and painless, as well as therapeutic first-pass metabolism. It can deliver medications through the skin portal to systemic circulation at a predefined rate while maintaining therapeutically efficacious concentrations for an extended period of time. Around 74% of medications are taken orally, and one has been discovered to be less effective than expected.In this present review article, it covers a brief outline of various recent approaches in their development for transdermal patches.
{"title":"A small review on recent advances in transdermal drug delivery system","authors":"Prakash Raj K, Rajakarthikeyan U, Saranraj L, Sivakumar L, R. Yuvhraj, Buvaneshvaran K","doi":"10.18231/j.ijpp.2024.003","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.003","url":null,"abstract":"Transdermal drug delivery devices (TDDS), often known as \"patches,\" are dosage forms designed to transfer a therapeutically effective amount of medicine over a patient's skin. Transdermal distribution establishes one of the most important channels for a revolutionary medication delivery method. Transdermal drug delivery has various advantages over traditional delivery methods, such as oral and injection; however, its efficacy is restricted. Transdermal administration traditionally entails pushing a patch containing a medicinal substance onto the skin, which is both convenient and painless, as well as therapeutic first-pass metabolism. It can deliver medications through the skin portal to systemic circulation at a predefined rate while maintaining therapeutically efficacious concentrations for an extended period of time. Around 74% of medications are taken orally, and one has been discovered to be less effective than expected.In this present review article, it covers a brief outline of various recent approaches in their development for transdermal patches.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.008
K. Katariya, Tushar Gosai, Akshay Hasmukhbhai Parmar
Hypertension (HTN) is a chronic condition with severe complications, so early detection and effective management are essential to prevent cardiovascular events and reduce the associated economic burden. This study aims to compare the cost-effectiveness of enalapril, amlodipine, and their combination in terms of blood pressure reduction, considering overall efficacy and economic implications. A prospective, observational cost-effectiveness analysis was conducted in 150 newly diagnosed hypertensive patients who were prescribed either enalapril (5 mg), amlodipine (5 mg), or enalapril plus amlodipine (2.5 mg each). The primary outcome was the difference in systolic and diastolic blood pressure between baseline and follow-up, as well as the evaluation of overall efficacy and cost. Based on the data, statistical analysis was carried out using ANOVA and post hoc Tukey tests for drug efficacy, and cost-effectiveness was compared using MS Excel. After 30 days, all treatments significantly reduced systolic and diastolic blood pressure (p = 0.0001). The combination therapy with a lower dose showed superior efficacy in blood pressure reduction and was most cost-effective, requiring less expense for a 1 mmHg reduction in blood pressure compared to individual drugs with a higher dose. Quality of life assessment favored low-dose combination therapy, with fewer reported adverse effects. The combinationof amlodipine and enalapril at a lower dose demonstrated superior cost-effectiveness, efficacy in blood pressure reduction, and a favorable impact on patients' quality of life compared to individual drugs at a higher dose. This suggests that combination therapy may be a preferred option in the management of hypertension, emphasizing the importance of considering both clinical and economic factors in treatment decisions.
{"title":"Cost-effective analysis of enalapril, amlodipine, and enalapril plus amlodipine combination in newly diagnosed patients of hypertension: A pharmacoeconomic comparison of the antihypertensive efficacy of drugs","authors":"K. Katariya, Tushar Gosai, Akshay Hasmukhbhai Parmar","doi":"10.18231/j.ijpp.2024.008","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.008","url":null,"abstract":"Hypertension (HTN) is a chronic condition with severe complications, so early detection and effective management are essential to prevent cardiovascular events and reduce the associated economic burden. This study aims to compare the cost-effectiveness of enalapril, amlodipine, and their combination in terms of blood pressure reduction, considering overall efficacy and economic implications. A prospective, observational cost-effectiveness analysis was conducted in 150 newly diagnosed hypertensive patients who were prescribed either enalapril (5 mg), amlodipine (5 mg), or enalapril plus amlodipine (2.5 mg each). The primary outcome was the difference in systolic and diastolic blood pressure between baseline and follow-up, as well as the evaluation of overall efficacy and cost. Based on the data, statistical analysis was carried out using ANOVA and post hoc Tukey tests for drug efficacy, and cost-effectiveness was compared using MS Excel. After 30 days, all treatments significantly reduced systolic and diastolic blood pressure (p = 0.0001). The combination therapy with a lower dose showed superior efficacy in blood pressure reduction and was most cost-effective, requiring less expense for a 1 mmHg reduction in blood pressure compared to individual drugs with a higher dose. Quality of life assessment favored low-dose combination therapy, with fewer reported adverse effects. The combinationof amlodipine and enalapril at a lower dose demonstrated superior cost-effectiveness, efficacy in blood pressure reduction, and a favorable impact on patients' quality of life compared to individual drugs at a higher dose. This suggests that combination therapy may be a preferred option in the management of hypertension, emphasizing the importance of considering both clinical and economic factors in treatment decisions.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"55 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.005
R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath
Monoclonal antibodies (mAbs) have transformed modern medicine through precision targeting and therapeutic efficacy. This summary summarises the development, applications, and comparative characteristics of mAbs in the context of antiviral medicines and antibiotic treatment durations. Monoclonal antibodies are designed to target specific antigens with great affinity and specificity, making them important for diagnostics and treatments. Anti-virulence mAbs, a type of mAb, target pathogen virulence factors rather than pathogens themselves, providing a promising technique for combating infectious diseases while limiting resistance development. When comparing the duration of antibiotic medication versus mAb treatment, mAbs frequently provide a shorter and more tailored therapeutic regimen. This can lead to better patient outcomes, less resistance, and a lower risk of side effects associated with long-term antibiotic usage. Antigen selection, hybridoma creation, antibody synthesis, purification, and characterization are all steps in the mAb development process, with advances like recombinant DNA technology improving efficiency and scalability.
单克隆抗体（mAbs）通过精准靶向和疗效改变了现代医学。本摘要从抗病毒药物和抗生素疗程的角度总结了 mAbs 的发展、应用和比较特性。单克隆抗体是针对特定抗原设计的，具有很强的亲和力和特异性，因此在诊断和治疗中非常重要。抗病毒 mAb 是 mAb 的一种，以病原体毒力因子而非病原体本身为靶标，为抗击传染病并限制抗药性的产生提供了一种前景广阔的技术。如果比较抗生素药物治疗和 mAb 治疗的持续时间，mAb 往往能提供更短、更有针对性的治疗方案。这能为患者带来更好的治疗效果，减少抗药性，并降低长期使用抗生素产生副作用的风险。抗原选择、杂交瘤创建、抗体合成、纯化和表征是 mAb 开发过程中的所有步骤，重组 DNA 技术等进步提高了效率和可扩展性。
{"title":"The impact of monoclonal antibodies in preventing antimicrobial resistance (AMR)","authors":"R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath","doi":"10.18231/j.ijpp.2024.005","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.005","url":null,"abstract":"Monoclonal antibodies (mAbs) have transformed modern medicine through precision targeting and therapeutic efficacy. This summary summarises the development, applications, and comparative characteristics of mAbs in the context of antiviral medicines and antibiotic treatment durations. Monoclonal antibodies are designed to target specific antigens with great affinity and specificity, making them important for diagnostics and treatments. Anti-virulence mAbs, a type of mAb, target pathogen virulence factors rather than pathogens themselves, providing a promising technique for combating infectious diseases while limiting resistance development. When comparing the duration of antibiotic medication versus mAb treatment, mAbs frequently provide a shorter and more tailored therapeutic regimen. This can lead to better patient outcomes, less resistance, and a lower risk of side effects associated with long-term antibiotic usage. Antigen selection, hybridoma creation, antibody synthesis, purification, and characterization are all steps in the mAb development process, with advances like recombinant DNA technology improving efficiency and scalability.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"117 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.007
Jijo P. Abraham, Reena R. Giri, Kavita M. Jaiswal
This cross-sectional study aims to assess the prescribing practices of physicians at a rural hospital in Western India, focusing on adherence to WHO prescribing indicators. The main research question addressed the extent of alignment with optimal prescribing standards. 1: Evaluate prescribing patterns in a rural hospital using WHO indicators. 2: Assess alignment with WHO standards and identify areas for improvement. 3: Understand demographic influences on prescribing. 4: Provide insights for optimizing rural healthcare delivery.A prospective, descriptive, cross-sectional approach was employed in the outpatient department of the rural hospital. A total of 604 prescriptions were sampled over two months, and data were collected using a random sampling method. The study followed ethical standards, and prescriptions were analyzed for demographic characteristics, prescribing patterns, and adherence to WHO indicators. The average number of drugs per prescription was 3.5, indicating a tendency towards polypharmacy. While 86% of drugs were prescribed generically, the study revealed areas of suboptimal adherence to WHO prescribing indicators, including antibiotic prescriptions (29%) and injectable use (50%). The analysis also highlighted disparities in prescribing patterns based on gender and age. The study provides valuable insights into prescribing practices in a rural healthcare setting, emphasizing the need for interventions to streamline prescriptions and enhance adherence to global standards. The identified areas for improvement include addressing polypharmacy, promoting generic prescribing, and optimizing antibiotic and injectable use.
{"title":"Assessing prescribing practices in a rural hospital: A cross-sectional study using WHO prescribing indicators","authors":"Jijo P. Abraham, Reena R. Giri, Kavita M. Jaiswal","doi":"10.18231/j.ijpp.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.007","url":null,"abstract":"This cross-sectional study aims to assess the prescribing practices of physicians at a rural hospital in Western India, focusing on adherence to WHO prescribing indicators. The main research question addressed the extent of alignment with optimal prescribing standards. 1: Evaluate prescribing patterns in a rural hospital using WHO indicators. 2: Assess alignment with WHO standards and identify areas for improvement. 3: Understand demographic influences on prescribing. 4: Provide insights for optimizing rural healthcare delivery.A prospective, descriptive, cross-sectional approach was employed in the outpatient department of the rural hospital. A total of 604 prescriptions were sampled over two months, and data were collected using a random sampling method. The study followed ethical standards, and prescriptions were analyzed for demographic characteristics, prescribing patterns, and adherence to WHO indicators. The average number of drugs per prescription was 3.5, indicating a tendency towards polypharmacy. While 86% of drugs were prescribed generically, the study revealed areas of suboptimal adherence to WHO prescribing indicators, including antibiotic prescriptions (29%) and injectable use (50%). The analysis also highlighted disparities in prescribing patterns based on gender and age. The study provides valuable insights into prescribing practices in a rural healthcare setting, emphasizing the need for interventions to streamline prescriptions and enhance adherence to global standards. The identified areas for improvement include addressing polypharmacy, promoting generic prescribing, and optimizing antibiotic and injectable use.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"53 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.004
Mehreen Imran, Semira
This is a dive into the history of several groundbreaking psychiatric drugs and their discoveries. The article begins by exploring the curious origin of the word “serendipity” following Horace Walpole’s encounter with a fairytale. This captivating emergence of “serendipity” is followed by an account of lithium discovered in 1817. About a century and a half later, lithium would receive FDA approval, becoming a cornerstone in the treatment of mania.The narrative meanders to other drugs that have a similar thread of serendipity woven into their beginnings— chlordiazepoxide, meprobamate, chlorpromazine, finally halting at iproniazid, an anti-tubercular agent that unexpectedly revealed its mood-enhancing potential and paved the way for the development of monoamine oxidase inhibitors as antidepressants.The authors navigate through the intricacies of chance and discovery that have influenced the trajectory of psychiatric drug development, leading to unexpected breakthroughs that have forever left their mark on the undeniably vast landscape that is mental health.
{"title":"Serendipity in psychotropic drugs: Unearthing the origins","authors":"Mehreen Imran, Semira","doi":"10.18231/j.ijpp.2024.004","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.004","url":null,"abstract":"This is a dive into the history of several groundbreaking psychiatric drugs and their discoveries. The article begins by exploring the curious origin of the word “serendipity” following Horace Walpole’s encounter with a fairytale. This captivating emergence of “serendipity” is followed by an account of lithium discovered in 1817. About a century and a half later, lithium would receive FDA approval, becoming a cornerstone in the treatment of mania.The narrative meanders to other drugs that have a similar thread of serendipity woven into their beginnings— chlordiazepoxide, meprobamate, chlorpromazine, finally halting at iproniazid, an anti-tubercular agent that unexpectedly revealed its mood-enhancing potential and paved the way for the development of monoamine oxidase inhibitors as antidepressants.The authors navigate through the intricacies of chance and discovery that have influenced the trajectory of psychiatric drug development, leading to unexpected breakthroughs that have forever left their mark on the undeniably vast landscape that is mental health.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"114 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijpp.2024.006
V. V. Sarode, Sadhna P. Gautam
One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.
{"title":"Investigation of effect of ellagic acid on premature ovarian insufficiency","authors":"V. V. Sarode, Sadhna P. Gautam","doi":"10.18231/j.ijpp.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijpp.2024.006","url":null,"abstract":"One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"54 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：