Assessment of the assembly behaviour and physicochemical parameters for the tetradecyltrimethylammonium bromide and promazine hydrochloride mixture: Impact of monohydroxy organic compounds

Abstract

This study investigates the assembly behaviour and physicochemical parameters of a drug-surfactant mixture comprising tetradecyltrimethylammonium bromide (TTAB) and promazine hydrochloride (PMZ) in water and aq. solutions of monohydroxy organic compounds (ethanol (EtOH), 1-propanol (1-PrOH), and 2-butanol (2-BuOH)) using conductometric method. The interaction between TTAB and PMZ has been characterized with the assessment of physicochemical quantities (critical micelle concentration (CMC), counter ion binding (β) and thermodynamic parameters (standard Gibbs energy (\({\Delta G}_{{\varvec{m}}}^{{\varvec{o}}}\)), enthalpy (\({\Delta H}_{{\varvec{m}}}^{{\varvec{o}}}\)), and entropy (\({\Delta S}_{{\varvec{m}}}^{{\varvec{o}}}\))). The introduction of PMZ with TTAB surfactant resulted in a reduction of the CMC value and an augmentation of the magnitude of β. The inclusion of alcohols causes the delaying creation of micelles above 5% w/w of all alcohols employed. The enhancement of CMC values was acquired with the increase of temperature for TTAB and PMZ mixture. The micellization of the TTAB + PMZ system was obtained as spontaneous with \({-\Delta G}_{{\varvec{m}}}^{{\varvec{o}}}\) values. The observed values of \({\Delta H}_{{\varvec{m}}}^{0}\) and \({\Delta S}_{{\varvec{m}}}^{0}\) indicate that, the entropy plays the main roles in the assembly of TTAB + PMZ in aq. media, while the association is governed by the joint contribution from enthalpy and entropy in aq. alcohol solutions. The hydrophobic interaction is the key forces of interaction between TTAB and PMZ in water medium, whereas hydrophobic and ion-induced dipole are the probable interaction in aq. alcohol media. The thermodynamic of transfer and entropy enthalpy compensation parameters are computed and described with proper logics.