Distribution and insecticide resistance profile of the major malaria vector Anopheles funestus group across the African continent Répartition et profil de résistance aux insecticides du groupe Anopheles Funestus, principal vecteur du paludisme, à travers le continent africain

IF 1.6 3区 农林科学 Q2 ENTOMOLOGY Medical and Veterinary Entomology Pub Date : 2024-02-02 DOI:10.1111/mve.12706
Dimitri W. Wangrawa, Joel O. Odero, Francesco Baldini, Fredros Okumu, Athanase Badolo
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Abstract

There has been significant progress in malaria control in the last 2 decades, with a decline in mortality and morbidity. However, these gains are jeopardised by insecticide resistance, which negatively impacts the core interventions, such as insecticide-treated nets (ITN) and indoor residual spraying (IRS). While most malaria control and research efforts are still focused on Anopheles gambiae complex mosquitoes, Anopheles funestus remains an important vector in many countries and, in some cases, contributes to most of the local transmission. As countries move towards malaria elimination, it is important to ensure that all dominant vector species, including An. funestus, an important vector in some countries, are targeted. The objective of this review is to compile and discuss information related to A. funestus populations' resistance to insecticides and the mechanisms involved across Africa, emphasising the sibling species and their resistance profiles in relation to malaria elimination goals. Data on insecticide resistance in An. funestus malaria vectors in Africa were extracted from published studies. Online bibliographic databases, including Google Scholar and PubMed, were used to search for relevant studies. Articles published between 2000 and May 2023 reporting resistance of An. funestus to insecticides and associated mechanisms were included. Those reporting only bionomics were excluded. Spatial variation in species distribution and resistance to insecticides was recorded from 174 articles that met the selection criteria. It was found that An. funestus was increasingly resistant to the four classes of insecticides recommended by the World Health Organisation for malaria vector control; however, this varied by country. Insecticide resistance appears to reduce the effectiveness of vector control methods, particularly IRS and ITN. Biochemical resistance due to detoxification enzymes (P450s and glutathione-S-transferases [GSTs]) in An. funestus was widely recorded. However, An. funestus in Africa remains susceptible to other insecticide classes, such as organophosphates and neonicotinoids. This review highlights the increasing insecticide resistance of An. funestus mosquitoes, which are important malaria vectors in Africa, posing a significant challenge to malaria control efforts. While An. funestus has shown resistance to the recommended insecticide classes, notably pyrethroids and, in some cases, organochlorides and carbamates, it remains susceptible to other classes of insecticides such as organophosphates and neonicotinoids, providing potential alternative options for vector control strategies. The study underscores the need for targeted interventions that consider the population structure and geographical distribution of An. funestus, including its sibling species and their insecticide resistance profiles, to effectively achieve malaria elimination goals.

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非洲大陆主要疟疾病媒按蚊群体的分布和杀虫剂抗药性概况Répartition et profil de résistance aux insecticides du groupe Anopheles Funestus, principal vecteur du paludisme, à travers le continent africain
过去 20 年间,疟疾控制工作取得了重大进展,死亡率和发病率均有所下降。然而,杀虫剂抗药性危及了这些成果,对驱虫蚊帐(ITN)和室内滞留喷洒(IRS)等核心干预措施产生了负面影响。虽然大多数疟疾控制和研究工作仍集中在冈比亚按蚊上,但在许多国家,真按蚊仍是重要的病媒,在某些情况下,真按蚊造成了当地的大部分传播。随着各国逐步消灭疟疾,必须确保所有主要病媒物种,包括一些国家的重要病媒按蚊,都是消灭的目标。本综述旨在汇编和讨论有关非洲疟原虫种群对杀虫剂的抗药性及相关机制的信息,并强调与消除疟疾目标相关的同胞种及其抗药性概况。有关非洲疟原虫疟疾病媒对杀虫剂的抗药性的数据来自已发表的研究。在线文献数据库(包括 Google Scholar 和 PubMed)用于搜索相关研究。收录了 2000 年至 2023 年 5 月间发表的报道疟原虫对杀虫剂的抗药性及相关机制的文章。仅报道仿生学的文章被排除在外。符合选择标准的 174 篇文章记录了物种分布和对杀虫剂抗性的空间变化。研究发现,疟原虫对世界卫生组织推荐用于疟疾病媒控制的四类杀虫剂的抗药性越来越强;但这一情况因国家而异。杀虫剂抗药性似乎降低了病媒控制方法的有效性,特别是 IRS 和 ITN。由于疟原虫体内的解毒酶(P450s 和谷胱甘肽-S-转移酶 [GSTs])而产生的生化抗药性被广泛记录在案。然而,非洲的 An. funestus 对有机磷类和新烟碱类等其他杀虫剂仍然易感。本综述强调了作为非洲重要疟疾病媒的疟蚊对杀虫剂的抗药性日益增强,这对疟疾控制工作构成了重大挑战。虽然疟蚊对推荐的杀虫剂类别(主要是拟除虫菊酯类,在某些情况下还包括有机氯和氨基甲酸酯类)表现出抗药性,但它对有机磷和新烟碱等其他类别的杀虫剂仍然易感,这为病媒控制策略提供了潜在的替代选择。这项研究强调,有必要采取有针对性的干预措施,考虑到疟原虫的种群结构和地理分布,包括其兄弟物种及其对杀虫剂的抗药性情况,以有效实现消灭疟疾的目标。
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来源期刊
Medical and Veterinary Entomology
Medical and Veterinary Entomology 农林科学-昆虫学
CiteScore
3.70
自引率
5.30%
发文量
65
审稿时长
12-24 weeks
期刊介绍: Medical and Veterinary Entomology is the leading periodical in its field. The Journal covers the biology and control of insects, ticks, mites and other arthropods of medical and veterinary importance. The main strengths of the Journal lie in the fields of: -epidemiology and transmission of vector-borne pathogens changes in vector distribution that have impact on the pathogen transmission- arthropod behaviour and ecology- novel, field evaluated, approaches to biological and chemical control methods- host arthropod interactions. Please note that we do not consider submissions in forensic entomology.
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