A Systematic Review of Electrochemical Sensing Devices Based on Metal-organic Frameworks for the Identification of Tumor Biomarkers

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2024-02-01 DOI:10.2174/0118756298276294231130111658
Aiany Maria Queiroz Felix, Karen Loraine Macena Santos, Severino Alves Júnior, Maria Danielly Lima Oliveira, César Augusto Souza de Andrade
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Abstract

Background:: Electrochemical sensors have attracted enormous interest in recent decades due to their relatively simple synthesis process, the possibility of modifications in their composition, and their wide application in detecting analytes. Method:: To achieve excellent performance, materials used in its construction must facilitate the transfer of electrons and provide a large surface area and excellent electrocatalytic activity. Because they are functional nanomaterials, metal-organic frameworks (MOFs) meet the criteria for application as a sensing material and can be used to build high-performance sensors for numerous applications. They play a relevant role in the early diagnosis of various neoplasms and tumor processes, thus providing better prognoses. Considering this universe, the present study focused on evaluating the application of these nanomaterials in the recognition of tumor biomarkers. Result:: A systematic review of scientific publications was performed using the following descriptors "MOFs", "Metal-organic frameworks", "Biosensor", "Electrochemistry", and "Tumor Biomarker". Conclusion:: Herein, we analyze recent innovations of MOF-based biosensors applied to the detection of tumor biomarkers, discussing how promising characteristics and properties of these materials were harnessed in the development of biosensors to provide a new contribution to future studies and the development of applied MOFs to electrochemical biosensing.
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基于金属有机框架的电化学传感设备用于鉴定肿瘤生物标记物的系统综述
背景::近几十年来,电化学传感器因其相对简单的合成过程、可对其成分进行改性以及在检测分析物方面的广泛应用而备受关注。方法:为了实现优异的性能,用于构建传感器的材料必须有利于电子转移,并具有较大的表面积和优异的电催化活性。金属有机框架(MOFs)是一种功能性纳米材料,符合传感材料的应用标准,可用于制造高性能传感器,应用领域广泛。它们在各种肿瘤和肿瘤过程的早期诊断中发挥着重要作用,从而提供更好的预后。有鉴于此,本研究重点评估了这些纳米材料在识别肿瘤生物标记物方面的应用。研究结果使用以下描述符 "MOFs"、"金属有机框架"、"生物传感器"、"电化学 "和 "肿瘤生物标志物 "对科学出版物进行了系统性审查。结论在此,我们分析了最近应用于肿瘤生物标记物检测的基于 MOF 的生物传感器的创新,讨论了如何在生物传感器的开发过程中利用这些材料的有前途的特征和特性,为未来的研究和开发应用 MOF 的电化学生物传感做出新的贡献。
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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