Pub Date : 2024-08-07DOI: 10.2174/0118756298307594240725104448
Ning Chen, Junyao Chu, Bing Liu, Ting Zhu, Yuxin Wang, Ting Li
Microbial derivatives are a significant source of antioxidants, with varying structures leading to different activities due to distinct structure-activity relationships. These structures include polyketones, alkaloids, terpenes, and fatty acids. Microbial-derived antioxidants offer unique advantages, such as diversity, high yield, customizability, sustainability, and biocompatibility, making them promising for various applications. This review aims to address the following objectives: (1) to explore the antioxidant activities of microbial derivatives with these specific structures, (2) to detail their biosynthesis processes, and (3) to lay the groundwork for their further utilization and development in diverse fields.
{"title":"Research Progress on Compounds with Antioxidant Activity Derived from Microorganisms","authors":"Ning Chen, Junyao Chu, Bing Liu, Ting Zhu, Yuxin Wang, Ting Li","doi":"10.2174/0118756298307594240725104448","DOIUrl":"https://doi.org/10.2174/0118756298307594240725104448","url":null,"abstract":"Microbial derivatives are a significant source of antioxidants, with varying structures leading to different activities due to distinct structure-activity relationships. These structures include polyketones, alkaloids, terpenes, and fatty acids. Microbial-derived antioxidants offer unique advantages, such as diversity, high yield, customizability, sustainability, and biocompatibility, making them promising for various applications. This review aims to address the following objectives: (1) to explore the antioxidant activities of microbial derivatives with these specific structures, (2) to detail their biosynthesis processes, and (3) to lay the groundwork for their further utilization and development in diverse fields.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"82 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.2174/0118756298321262240719103850
Popuri Sureshbabu, Priyanka Chaudhary
Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.
{"title":"Synthesis of Indazole Scaffolds from Arynes and Suitable Coupling Partners - A Brief Review","authors":"Popuri Sureshbabu, Priyanka Chaudhary","doi":"10.2174/0118756298321262240719103850","DOIUrl":"https://doi.org/10.2174/0118756298321262240719103850","url":null,"abstract":"Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"122 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.2174/0118756298304506240628062045
Zahra Mazidi, Hamid Reza Garshasbi, Seyed Morteza Naghib, Mojgan Heydari, M. R. Mozafari
: The toxicity of systemic release in common drug delivery has irreversible effects on various tissues and organs of the body. The use of programmed biopolymers sensitive to the body's physiological conditions for targeted drug delivery has attracted extensive consideration. There are numerous benefits to this approach. The need for appropriate biopolymers for drug carriers suitable for programmed cargo delivery is a crucial challenge for biologists and physicists. Summarizing such materials can be very helpful in selecting the right materials. Extensive advances and many capabilities in the field of biopolymers have led to their increasing daily use, and among other materials, this research on biopolymers. In this study, the most important polymers for programmed drug delivery are introduced. We have tried to discuss the effective properties of materials in smart stimuli-sensitive drug delivery, their advantages and disadvantages, different forms, how to use them as a smart carrier, and their absorption mechanism.
{"title":"Multifunctional Smart Nano Biopolymers for Programmed Controlled Release of Biomolecules and Therapeutic Agents: An Overview on Modern Emerging Systems","authors":"Zahra Mazidi, Hamid Reza Garshasbi, Seyed Morteza Naghib, Mojgan Heydari, M. R. Mozafari","doi":"10.2174/0118756298304506240628062045","DOIUrl":"https://doi.org/10.2174/0118756298304506240628062045","url":null,"abstract":": The toxicity of systemic release in common drug delivery has irreversible effects on various tissues and organs of the body. The use of programmed biopolymers sensitive to the body's physiological conditions for targeted drug delivery has attracted extensive consideration. There are numerous benefits to this approach. The need for appropriate biopolymers for drug carriers suitable for programmed cargo delivery is a crucial challenge for biologists and physicists. Summarizing such materials can be very helpful in selecting the right materials. Extensive advances and many capabilities in the field of biopolymers have led to their increasing daily use, and among other materials, this research on biopolymers. In this study, the most important polymers for programmed drug delivery are introduced. We have tried to discuss the effective properties of materials in smart stimuli-sensitive drug delivery, their advantages and disadvantages, different forms, how to use them as a smart carrier, and their absorption mechanism.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"36 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141738880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0118756298313032240529094738
Bing Liu, Jinhua Wu, Ting Zhu, Xue Tian, Ning Chen, Wenlan Li, Ting Li
: The imidazole ring is a five membered ring with a simple chemical structure and is widely present in natural products. Due to its unique chemical structure, it is beneficial for the imidazole ring to bind with other functional groups, thus exhibiting a wide range of biological activities. The synthesis of imidazole derivatives often involves the Debus method, Michael addition method, and the use of existing materials to synthesize target compounds through one-pot synthesis. Imidazole compounds have numerous medicinal properties and physiological activities, including antioxidant, antibacterial, anti-inflammatory, antihistamine, hypoglycemic, antiviral, antihypertensive and anticancer effects. In addition to its medicinal chemical significance, imidazole also has industrial applications such as corrosion inhibitors, flame retardants, photography, and electronics. The synthesis and activity research of imidazole and its derivatives have good development prospects. This article reviews the chemical synthesis and biosynthesis of imidazole derivatives, as well as their biological activities.
{"title":"Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Imidazole Alkaloids","authors":"Bing Liu, Jinhua Wu, Ting Zhu, Xue Tian, Ning Chen, Wenlan Li, Ting Li","doi":"10.2174/0118756298313032240529094738","DOIUrl":"https://doi.org/10.2174/0118756298313032240529094738","url":null,"abstract":": The imidazole ring is a five membered ring with a simple chemical structure and is widely present in natural products. Due to its unique chemical structure, it is beneficial for the imidazole ring to bind with other functional groups, thus exhibiting a wide range of biological activities. The synthesis of imidazole derivatives often involves the Debus method, Michael addition method, and the use of existing materials to synthesize target compounds through one-pot synthesis. Imidazole compounds have numerous medicinal properties and physiological activities, including antioxidant, antibacterial, anti-inflammatory, antihistamine, hypoglycemic, antiviral, antihypertensive and anticancer effects. In addition to its medicinal chemical significance, imidazole also has industrial applications such as corrosion inhibitors, flame retardants, photography, and electronics. The synthesis and activity research of imidazole and its derivatives have good development prospects. This article reviews the chemical synthesis and biosynthesis of imidazole derivatives, as well as their biological activities.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"111 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141529934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0118756298307930240531072440
Nusrat Shafiq, Asna Jannat, Maryam Rashid, Shagufta Parveen, Nadia Noor
: This review is about a class of plant polyphenols known as Stilbenes. Resveratrol – the first stilbene was extracted from White Hellebore in 1940, since then 400 plus stilbene derivatives have been discovered. The core purpose of this paper is to summarize the history, extraction sources, biosynthesis and chemical synthesis and applications of stilbenes. Apart from biosynthesis, its novel derivatives are being synthesized in laboratories. This class of compounds has extensive clinical (including antioxidant, anticancer, anti-inflammatory activities etc.) and industrial applications such as optical dyes, laser dyes, scintillators, etc.
{"title":"A Comprehensive Review on History, Sources, Biosynthesis, Chemical Synthesis and Applications of Stilbenes","authors":"Nusrat Shafiq, Asna Jannat, Maryam Rashid, Shagufta Parveen, Nadia Noor","doi":"10.2174/0118756298307930240531072440","DOIUrl":"https://doi.org/10.2174/0118756298307930240531072440","url":null,"abstract":": This review is about a class of plant polyphenols known as Stilbenes. Resveratrol – the first stilbene was extracted from White Hellebore in 1940, since then 400 plus stilbene derivatives have been discovered. The core purpose of this paper is to summarize the history, extraction sources, biosynthesis and chemical synthesis and applications of stilbenes. Apart from biosynthesis, its novel derivatives are being synthesized in laboratories. This class of compounds has extensive clinical (including antioxidant, anticancer, anti-inflammatory activities etc.) and industrial applications such as optical dyes, laser dyes, scintillators, etc.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"18 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-28DOI: 10.2174/0118756298310340240514060824
Bing Liu, Lijing Zhang, Ting Zhu, Yuxin Wang, Ning Chen, Wenlan Li, Ting Li
:: Indole alkaloids are a class of secondary metabolites with a wide range of biological activities. The chemical structure of indole alkaloids is relatively complex, but all of them have a remarkable structural feature, which is a five-membered pyrrole cyclocyclobenzene ring. Because of the unique structural characteristics of indole alkaloids, they have also a wide range of pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, anti-viral, anti-hepatitis, antidiabetes, neuroprotective, lipid-lowering and so on. For example, indole alkaloids have been shown to show anticancer activity through various anti-proliferation mechanisms and play an important role in the research of novel cancer treatment advances. In this article, we reviewed the recent progress of indole alkaloids isolated from microorganisms and their chemical and biosynthesis, which laid a foundation for further utilization and development of indole alkaloids.
{"title":"Research Progress on Active Indole Alkaloids in Microorganisms","authors":"Bing Liu, Lijing Zhang, Ting Zhu, Yuxin Wang, Ning Chen, Wenlan Li, Ting Li","doi":"10.2174/0118756298310340240514060824","DOIUrl":"https://doi.org/10.2174/0118756298310340240514060824","url":null,"abstract":":: Indole alkaloids are a class of secondary metabolites with a wide range of biological activities. The chemical structure of indole alkaloids is relatively complex, but all of them have a remarkable structural feature, which is a five-membered pyrrole cyclocyclobenzene ring. Because of the unique structural characteristics of indole alkaloids, they have also a wide range of pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, anti-viral, anti-hepatitis, antidiabetes, neuroprotective, lipid-lowering and so on. For example, indole alkaloids have been shown to show anticancer activity through various anti-proliferation mechanisms and play an important role in the research of novel cancer treatment advances. In this article, we reviewed the recent progress of indole alkaloids isolated from microorganisms and their chemical and biosynthesis, which laid a foundation for further utilization and development of indole alkaloids.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"428 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141171451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.2174/0118756298296678240402080951
Jinli Hou, Mosstafa Kazemi
In chemistry, thiazoles and their derivatives constitute a significant class of biologically active molecules that are thought to be the fundamental building blocks of numerous other biologically active compounds. Many synthetic pharmaceuticals, including fungicides, dyes, antimicrobials, and anticonvulsants, are made using thiazoles and their derivatives as an intermediary. Thus, one of the main areas of organic synthesis research is the presentation of effective and environmentally acceptable catalytic methods for the synthesis of thiazole derivatives. Over the past ten years, organic synthesis in chemistry has been completely transformed by the use of magnetic nanocomposites as catalysts. Magnetic nanoparticles are very stable and easily manipulated on the surface, which can result in the creation of an efficient catalyst. The main feature of magnetic nanocatalysts is their ability to be easily separated from the reaction mixture using only an external magnet. In recent years, several magnetic nanocatalysts have been reported to produce various thiazole compounds. We will look at these methods and talk about the characteristics of these catalytic systems in this post. This review will be helpful for synthetic chemists who are interested in magnetic nanocatalysts and working in the field of thiazole synthesis.
{"title":"A Comprehensive Review on Synthesis of Thiazoles: Research on Magnetically Recoverable Catalysts","authors":"Jinli Hou, Mosstafa Kazemi","doi":"10.2174/0118756298296678240402080951","DOIUrl":"https://doi.org/10.2174/0118756298296678240402080951","url":null,"abstract":"In chemistry, thiazoles and their derivatives constitute a significant class of biologically active molecules that are thought to be the fundamental building blocks of numerous other biologically active compounds. Many synthetic pharmaceuticals, including fungicides, dyes, antimicrobials, and anticonvulsants, are made using thiazoles and their derivatives as an intermediary. Thus, one of the main areas of organic synthesis research is the presentation of effective and environmentally acceptable catalytic methods for the synthesis of thiazole derivatives. Over the past ten years, organic synthesis in chemistry has been completely transformed by the use of magnetic nanocomposites as catalysts. Magnetic nanoparticles are very stable and easily manipulated on the surface, which can result in the creation of an efficient catalyst. The main feature of magnetic nanocatalysts is their ability to be easily separated from the reaction mixture using only an external magnet. In recent years, several magnetic nanocatalysts have been reported to produce various thiazole compounds. We will look at these methods and talk about the characteristics of these catalytic systems in this post. This review will be helpful for synthetic chemists who are interested in magnetic nanocatalysts and working in the field of thiazole synthesis.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"60 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.2174/0118756298298861240401074137
Qianqian Lei, Zaoduan Wu, Yu Ye, Huifang Xie, Chen Zhang, Xiangqi Yang, Bangbang Li, Hao Xu, Zehua Yang
: Gem-dimethyl bicyclic [3.1.0] proline, an azadicyclohexane derivative, constitutes a prevalent skeleton structure in drugs, which serves an important role in the synthesis of antiviral drugs, such as Nirmatrelvir, Boceprevir, Narlaprevir, etc. This study offers a comprehensive overview of the documented synthetic strategies for gem-dimethyl bicyclic [3.1.0] proline methyl ester and delves into the application characteristics of each synthetic strategy. These synthetic approaches can be divided into three major types: the first synthetic method uses proline derivatives as the starting material, the second one uses cyclopropane derivatives as the starting material, and the third one uses the bicyclic skeleton as the starting material. Of these strategies, the third method stands out as the most extensively adopted.
{"title":"Synthesis of Gem-Dimethyl Bicyclic [3.1.0] Proline as an Antiviral Drug Intermediate","authors":"Qianqian Lei, Zaoduan Wu, Yu Ye, Huifang Xie, Chen Zhang, Xiangqi Yang, Bangbang Li, Hao Xu, Zehua Yang","doi":"10.2174/0118756298298861240401074137","DOIUrl":"https://doi.org/10.2174/0118756298298861240401074137","url":null,"abstract":": Gem-dimethyl bicyclic [3.1.0] proline, an azadicyclohexane derivative, constitutes a prevalent skeleton structure in drugs, which serves an important role in the synthesis of antiviral drugs, such as Nirmatrelvir, Boceprevir, Narlaprevir, etc. This study offers a comprehensive overview of the documented synthetic strategies for gem-dimethyl bicyclic [3.1.0] proline methyl ester and delves into the application characteristics of each synthetic strategy. These synthetic approaches can be divided into three major types: the first synthetic method uses proline derivatives as the starting material, the second one uses cyclopropane derivatives as the starting material, and the third one uses the bicyclic skeleton as the starting material. Of these strategies, the third method stands out as the most extensively adopted.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"34 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.2174/0118756298299464240402045438
Ravi Varala, Vittal Seema, Mohammed Hussein, Mostafa A. Ismail, M. Mujahid Alam
: meta-Chloroperbenzoic acid (mCPBA) is a readily available peroxide that is a powerful oxidizing agent utilized in a range of oxidative reactions. Metal-free oxidations mediated by mCPBA involving selective oxidation of aliphatic amines to oximes, selective oxidation of organosulphides/ aldehydes, synthesis of heterocyclic N-oxides, domino C[sp2] hydroxylation/ annulation of enaminones (heterocyclic ring formation), acid to phenol conversion, oxidation of exocyclic C=C bond, oxidative ring contraction, etc. have been comprehensively and critically examined in this mini-review from 2015 to date.
{"title":"Metal-free Oxidations with m-CPBA: An Octennial Update","authors":"Ravi Varala, Vittal Seema, Mohammed Hussein, Mostafa A. Ismail, M. Mujahid Alam","doi":"10.2174/0118756298299464240402045438","DOIUrl":"https://doi.org/10.2174/0118756298299464240402045438","url":null,"abstract":": meta-Chloroperbenzoic acid (mCPBA) is a readily available peroxide that is a powerful oxidizing agent utilized in a range of oxidative reactions. Metal-free oxidations mediated by mCPBA involving selective oxidation of aliphatic amines to oximes, selective oxidation of organosulphides/ aldehydes, synthesis of heterocyclic N-oxides, domino C[sp2] hydroxylation/ annulation of enaminones (heterocyclic ring formation), acid to phenol conversion, oxidation of exocyclic C=C bond, oxidative ring contraction, etc. have been comprehensively and critically examined in this mini-review from 2015 to date.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"57 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.2174/0118756298284383240110080227
Ning Chen, Xue Tian, Bing Liu, Ting Zhu, Jintong Zhao, Ting Li
: Cyclodepsipeptides, mainly derived from marine organisms and soil microorganisms, are amphiphilic molecules consisting of short oligopeptides with fatty acid tails attached to form a macrocyclic structure. Studies on the activity of cyclodepsipeptides have shown that they have cytotoxicity, antibacterial and anthelmintic effects, and are widely used in biological control, drug development, environmental remediation and disease treatment. Cyclodepsipeptides play a prominent role in the development of new drugs and drug lead compounds, especially as antibiotics with great medicinal potentiall, and are slowly seeping into the public consciousness. The biosynthesis of cyclodepsipeptides is mainly based on the synthesis of non-ribosomal peptide synthases, and selection of key regulatory enzymes for homologue regulation and biosynthetic strategies using genetic engineering and metabolic engineering approaches. The biosynthesis method is miniaturised, recyclable, and safer. The total synthesis methods of cyclodepsipeptides are mainly combined solid-liquid phase methods, which synthesise cyclodepsipeptides faster and are easy to purify. This paper reviews the biological activities of cyclodepsipeptides, their biosynthesis, and total synthesis.
{"title":"Cyclodepsipeptides: Isolation, Bioactivities, Biosynthesis and Total Synthesis","authors":"Ning Chen, Xue Tian, Bing Liu, Ting Zhu, Jintong Zhao, Ting Li","doi":"10.2174/0118756298284383240110080227","DOIUrl":"https://doi.org/10.2174/0118756298284383240110080227","url":null,"abstract":": Cyclodepsipeptides, mainly derived from marine organisms and soil microorganisms, are amphiphilic molecules consisting of short oligopeptides with fatty acid tails attached to form a macrocyclic structure. Studies on the activity of cyclodepsipeptides have shown that they have cytotoxicity, antibacterial and anthelmintic effects, and are widely used in biological control, drug development, environmental remediation and disease treatment. Cyclodepsipeptides play a prominent role in the development of new drugs and drug lead compounds, especially as antibiotics with great medicinal potentiall, and are slowly seeping into the public consciousness. The biosynthesis of cyclodepsipeptides is mainly based on the synthesis of non-ribosomal peptide synthases, and selection of key regulatory enzymes for homologue regulation and biosynthetic strategies using genetic engineering and metabolic engineering approaches. The biosynthesis method is miniaturised, recyclable, and safer. The total synthesis methods of cyclodepsipeptides are mainly combined solid-liquid phase methods, which synthesise cyclodepsipeptides faster and are easy to purify. This paper reviews the biological activities of cyclodepsipeptides, their biosynthesis, and total synthesis.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"254 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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