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Research Progress on Compounds with Antioxidant Activity Derived from Microorganisms 从微生物中提取具有抗氧化活性的化合物的研究进展
IF 2.3 4区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-08-07 DOI: 10.2174/0118756298307594240725104448
Ning Chen, Junyao Chu, Bing Liu, Ting Zhu, Yuxin Wang, Ting Li
Microbial derivatives are a significant source of antioxidants, with varying structures leading to different activities due to distinct structure-activity relationships. These structures include polyketones, alkaloids, terpenes, and fatty acids. Microbial-derived antioxidants offer unique advantages, such as diversity, high yield, customizability, sustainability, and biocompatibility, making them promising for various applications. This review aims to address the following objectives: (1) to explore the antioxidant activities of microbial derivatives with these specific structures, (2) to detail their biosynthesis processes, and (3) to lay the groundwork for their further utilization and development in diverse fields.
微生物衍生物是抗氧化剂的重要来源,其结构各不相同,因此具有不同的结构-活性关系。这些结构包括聚酮、生物碱、萜烯和脂肪酸。微生物衍生抗氧化剂具有独特的优势,如多样性、高产率、可定制性、可持续性和生物相容性,因此在各种应用中大有可为。本综述旨在探讨以下目标:(1)探索具有这些特定结构的微生物衍生物的抗氧化活性;(2)详细介绍其生物合成过程;(3)为其在不同领域的进一步利用和发展奠定基础。
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引用次数: 0
Synthesis of Indazole Scaffolds from Arynes and Suitable Coupling Partners - A Brief Review 从芳香烃和合适的偶联剂合成吲唑支架 - 简要回顾
IF 2.3 4区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-08-02 DOI: 10.2174/0118756298321262240719103850
Popuri Sureshbabu, Priyanka Chaudhary
Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.
无过渡金属环化/级联反应已被视为获得碳水化合物/杂环分子的强大合成工具。其中,苄烯化学因其在不同反应条件下通过不寻常的碳-碳(C-C)或碳-异原子(C-O、C-N、C-S)键形成的多种功能化烯而备受关注。在本综述中,使用苄烯前体和其他各种偶联剂构建具有合成和制药价值的吲唑支架的动态方法很少。在这篇微型综述中,我们介绍了无金属级联策略的最新进展,重点介绍了几位合成化学家的贡献,包括我们的研究工作。我们还特别注意提供详细的机理途径来解释所开发的方法。
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引用次数: 0
Multifunctional Smart Nano Biopolymers for Programmed Controlled Release of Biomolecules and Therapeutic Agents: An Overview on Modern Emerging Systems 用于生物分子和治疗剂程序控制释放的多功能智能纳米生物聚合物:现代新兴系统概述
IF 2.3 4区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-07-18 DOI: 10.2174/0118756298304506240628062045
Zahra Mazidi, Hamid Reza Garshasbi, Seyed Morteza Naghib, Mojgan Heydari, M. R. Mozafari
: The toxicity of systemic release in common drug delivery has irreversible effects on various tissues and organs of the body. The use of programmed biopolymers sensitive to the body's physiological conditions for targeted drug delivery has attracted extensive consideration. There are numerous benefits to this approach. The need for appropriate biopolymers for drug carriers suitable for programmed cargo delivery is a crucial challenge for biologists and physicists. Summarizing such materials can be very helpful in selecting the right materials. Extensive advances and many capabilities in the field of biopolymers have led to their increasing daily use, and among other materials, this research on biopolymers. In this study, the most important polymers for programmed drug delivery are introduced. We have tried to discuss the effective properties of materials in smart stimuli-sensitive drug delivery, their advantages and disadvantages, different forms, how to use them as a smart carrier, and their absorption mechanism.
:普通给药的全身释放毒性会对人体的各种组织和器官产生不可逆的影响。使用对人体生理条件敏感的程序化生物聚合物进行靶向给药已引起广泛关注。这种方法有许多好处。生物学家和物理学家面临的一个重要挑战是,需要合适的生物聚合物作为药物载体,以实现程序化货物递送。总结这类材料对选择合适的材料很有帮助。生物聚合物领域取得的广泛进展和具备的多种能力使其在日常使用中日益增多,在其他材料中,本研究对生物聚合物进行了研究。本研究介绍了用于程序化给药的最重要聚合物。我们试图讨论这些材料在智能刺激敏感给药方面的有效特性、它们的优缺点、不同形式、如何将它们用作智能载体以及它们的吸收机制。
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引用次数: 0
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Imidazole Alkaloids 生物活性咪唑生物碱的化学合成与生物合成研究进展
IF 2.3 4区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-06-24 DOI: 10.2174/0118756298313032240529094738
Bing Liu, Jinhua Wu, Ting Zhu, Xue Tian, Ning Chen, Wenlan Li, Ting Li
: The imidazole ring is a five membered ring with a simple chemical structure and is widely present in natural products. Due to its unique chemical structure, it is beneficial for the imidazole ring to bind with other functional groups, thus exhibiting a wide range of biological activities. The synthesis of imidazole derivatives often involves the Debus method, Michael addition method, and the use of existing materials to synthesize target compounds through one-pot synthesis. Imidazole compounds have numerous medicinal properties and physiological activities, including antioxidant, antibacterial, anti-inflammatory, antihistamine, hypoglycemic, antiviral, antihypertensive and anticancer effects. In addition to its medicinal chemical significance, imidazole also has industrial applications such as corrosion inhibitors, flame retardants, photography, and electronics. The synthesis and activity research of imidazole and its derivatives have good development prospects. This article reviews the chemical synthesis and biosynthesis of imidazole derivatives, as well as their biological activities.
:咪唑环是一个化学结构简单的五元环,广泛存在于天然产品中。由于其独特的化学结构,咪唑环有利于与其他官能团结合,从而表现出广泛的生物活性。咪唑衍生物的合成通常涉及 Debus 法、迈克尔加成法以及利用现有材料通过一锅合成法合成目标化合物。咪唑类化合物具有多种药用特性和生理活性,包括抗氧化、抗菌、抗炎、抗组胺、降血糖、抗病毒、降血压和抗癌作用。咪唑除了具有医药化学意义外,还具有工业应用价值,如缓蚀剂、阻燃剂、摄影和电子产品等。咪唑及其衍生物的合成和活性研究具有良好的发展前景。本文综述了咪唑衍生物的化学合成、生物合成及其生物活性。
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引用次数: 0
A Comprehensive Review on History, Sources, Biosynthesis, Chemical Synthesis and Applications of Stilbenes 关于二苯乙烯类化合物的历史、来源、生物合成、化学合成和应用的全面综述
IF 2.3 4区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-06-24 DOI: 10.2174/0118756298307930240531072440
Nusrat Shafiq, Asna Jannat, Maryam Rashid, Shagufta Parveen, Nadia Noor
: This review is about a class of plant polyphenols known as Stilbenes. Resveratrol – the first stilbene was extracted from White Hellebore in 1940, since then 400 plus stilbene derivatives have been discovered. The core purpose of this paper is to summarize the history, extraction sources, biosynthesis and chemical synthesis and applications of stilbenes. Apart from biosynthesis, its novel derivatives are being synthesized in laboratories. This class of compounds has extensive clinical (including antioxidant, anticancer, anti-inflammatory activities etc.) and industrial applications such as optical dyes, laser dyes, scintillators, etc.
:这篇综述介绍的是一类被称为二苯乙烯的植物多酚。白藜芦醇--第一个二苯乙烯类化合物是 1940 年从白鹤滩中提取的,此后又发现了 400 多种二苯乙烯类衍生物。本文的核心目的是概述二苯乙烯类化合物的历史、提取来源、生物合成、化学合成和应用。除了生物合成外,实验室还在合成其新型衍生物。这类化合物具有广泛的临床(包括抗氧化、抗癌、抗炎等活性)和工业应用,如光学染料、激光染料、闪烁体等。
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引用次数: 0
Research Progress on Active Indole Alkaloids in Microorganisms 微生物中活性吲哚生物碱的研究进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2024-05-28 DOI: 10.2174/0118756298310340240514060824
Bing Liu, Lijing Zhang, Ting Zhu, Yuxin Wang, Ning Chen, Wenlan Li, Ting Li
:: Indole alkaloids are a class of secondary metabolites with a wide range of biological activities. The chemical structure of indole alkaloids is relatively complex, but all of them have a remarkable structural feature, which is a five-membered pyrrole cyclocyclobenzene ring. Because of the unique structural characteristics of indole alkaloids, they have also a wide range of pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, anti-viral, anti-hepatitis, antidiabetes, neuroprotective, lipid-lowering and so on. For example, indole alkaloids have been shown to show anticancer activity through various anti-proliferation mechanisms and play an important role in the research of novel cancer treatment advances. In this article, we reviewed the recent progress of indole alkaloids isolated from microorganisms and their chemical and biosynthesis, which laid a foundation for further utilization and development of indole alkaloids.
::吲哚生物碱是一类具有广泛生物活性的次级代谢产物。吲哚生物碱的化学结构相对复杂,但它们都有一个显著的结构特征,那就是都有一个五元吡咯环。由于吲哚生物碱独特的结构特点,它们还具有广泛的药理活性,如抗菌、抗炎、抗肿瘤、抗病毒、抗肝炎、抗糖尿病、神经保护、降血脂等。例如,吲哚生物碱通过各种抗增殖机制显示出抗癌活性,在新型癌症治疗进展的研究中发挥着重要作用。本文综述了近年来从微生物中分离出的吲哚生物碱及其化学和生物合成的研究进展,为进一步利用和开发吲哚生物碱奠定了基础。
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引用次数: 0
A Comprehensive Review on Synthesis of Thiazoles: Research on Magnetically Recoverable Catalysts 噻唑合成综述:磁性可回收催化剂研究
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2024-04-30 DOI: 10.2174/0118756298296678240402080951
Jinli Hou, Mosstafa Kazemi
In chemistry, thiazoles and their derivatives constitute a significant class of biologically active molecules that are thought to be the fundamental building blocks of numerous other biologically active compounds. Many synthetic pharmaceuticals, including fungicides, dyes, antimicrobials, and anticonvulsants, are made using thiazoles and their derivatives as an intermediary. Thus, one of the main areas of organic synthesis research is the presentation of effective and environmentally acceptable catalytic methods for the synthesis of thiazole derivatives. Over the past ten years, organic synthesis in chemistry has been completely transformed by the use of magnetic nanocomposites as catalysts. Magnetic nanoparticles are very stable and easily manipulated on the surface, which can result in the creation of an efficient catalyst. The main feature of magnetic nanocatalysts is their ability to be easily separated from the reaction mixture using only an external magnet. In recent years, several magnetic nanocatalysts have been reported to produce various thiazole compounds. We will look at these methods and talk about the characteristics of these catalytic systems in this post. This review will be helpful for synthetic chemists who are interested in magnetic nanocatalysts and working in the field of thiazole synthesis.
在化学领域,噻唑及其衍生物是一类重要的生物活性分子,被认为是许多其他生物活性化合物的基本组成成分。许多合成药物,包括杀菌剂、染料、抗菌剂和抗惊厥剂,都是以噻唑及其衍生物为中间体制成的。因此,有机合成研究的主要领域之一是提出合成噻唑衍生物的有效且环境可接受的催化方法。在过去的十年中,使用磁性纳米复合材料作为催化剂彻底改变了化学中的有机合成。磁性纳米粒子非常稳定,且表面易于操作,因此可以制造出高效的催化剂。磁性纳米催化剂的主要特点是只需使用外部磁铁,就能很容易地从反应混合物中分离出来。近年来,有报道称几种磁性纳米催化剂可用于生产各种噻唑化合物。我们将在这篇文章中介绍这些方法,并谈谈这些催化系统的特点。这篇综述将对那些对磁性纳米催化剂感兴趣并从事噻唑合成领域工作的合成化学家有所帮助。
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引用次数: 0
Synthesis of Gem-Dimethyl Bicyclic [3.1.0] Proline as an Antiviral Drug Intermediate 作为抗病毒药物中间体的宝石-二甲基双环 [3.1.0] 脯氨酸的合成
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2024-04-30 DOI: 10.2174/0118756298298861240401074137
Qianqian Lei, Zaoduan Wu, Yu Ye, Huifang Xie, Chen Zhang, Xiangqi Yang, Bangbang Li, Hao Xu, Zehua Yang
: Gem-dimethyl bicyclic [3.1.0] proline, an azadicyclohexane derivative, constitutes a prevalent skeleton structure in drugs, which serves an important role in the synthesis of antiviral drugs, such as Nirmatrelvir, Boceprevir, Narlaprevir, etc. This study offers a comprehensive overview of the documented synthetic strategies for gem-dimethyl bicyclic [3.1.0] proline methyl ester and delves into the application characteristics of each synthetic strategy. These synthetic approaches can be divided into three major types: the first synthetic method uses proline derivatives as the starting material, the second one uses cyclopropane derivatives as the starting material, and the third one uses the bicyclic skeleton as the starting material. Of these strategies, the third method stands out as the most extensively adopted.
:宝石二甲基双环[3.1.0]脯氨酸是一种叠氮二环己烷衍生物,是药物中普遍存在的骨架结构,在Nirmatrelvir、Boceprevir、Narlaprevir等抗病毒药物的合成中发挥着重要作用。本研究全面概述了 gem-dimethyl 双环 [3.1.0] 脯氨酸甲酯的文献合成策略,并深入探讨了每种合成策略的应用特点。这些合成方法可分为三大类:第一类合成方法以脯氨酸衍生物为起始原料,第二类合成方法以环丙烷衍生物为起始原料,第三类合成方法以双环骨架为起始原料。在这些策略中,第三种方法被最广泛地采用。
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引用次数: 0
Metal-free Oxidations with m-CPBA: An Octennial Update m-CPBA 的无金属氧化作用:十年更新
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2024-04-17 DOI: 10.2174/0118756298299464240402045438
Ravi Varala, Vittal Seema, Mohammed Hussein, Mostafa A. Ismail, M. Mujahid Alam
: meta-Chloroperbenzoic acid (mCPBA) is a readily available peroxide that is a powerful oxidizing agent utilized in a range of oxidative reactions. Metal-free oxidations mediated by mCPBA involving selective oxidation of aliphatic amines to oximes, selective oxidation of organosulphides/ aldehydes, synthesis of heterocyclic N-oxides, domino C[sp2] hydroxylation/ annulation of enaminones (heterocyclic ring formation), acid to phenol conversion, oxidation of exocyclic C=C bond, oxidative ring contraction, etc. have been comprehensively and critically examined in this mini-review from 2015 to date.
甲氧氯过苯二甲酸(mCPBA)是一种易于获得的过氧化物,是一种可用于一系列氧化反应的强氧化剂。由 mCPBA 介导的无金属氧化反应涉及脂肪胺到肟的选择性氧化、有机硫化物/醛的选择性氧化、杂环 N-氧化物的合成、烯胺酮的多米诺 C[sp2] 羟基化/环化(杂环形成)、酸到酚的转化、外环 C=C 键的氧化、氧化缩环等。
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引用次数: 0
Cyclodepsipeptides: Isolation, Bioactivities, Biosynthesis and Total Synthesis 环表肽:分离、生物活性、生物合成和全合成
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2024-02-22 DOI: 10.2174/0118756298284383240110080227
Ning Chen, Xue Tian, Bing Liu, Ting Zhu, Jintong Zhao, Ting Li
: Cyclodepsipeptides, mainly derived from marine organisms and soil microorganisms, are amphiphilic molecules consisting of short oligopeptides with fatty acid tails attached to form a macrocyclic structure. Studies on the activity of cyclodepsipeptides have shown that they have cytotoxicity, antibacterial and anthelmintic effects, and are widely used in biological control, drug development, environmental remediation and disease treatment. Cyclodepsipeptides play a prominent role in the development of new drugs and drug lead compounds, especially as antibiotics with great medicinal potentiall, and are slowly seeping into the public consciousness. The biosynthesis of cyclodepsipeptides is mainly based on the synthesis of non-ribosomal peptide synthases, and selection of key regulatory enzymes for homologue regulation and biosynthetic strategies using genetic engineering and metabolic engineering approaches. The biosynthesis method is miniaturised, recyclable, and safer. The total synthesis methods of cyclodepsipeptides are mainly combined solid-liquid phase methods, which synthesise cyclodepsipeptides faster and are easy to purify. This paper reviews the biological activities of cyclodepsipeptides, their biosynthesis, and total synthesis.
:环十二肽主要来源于海洋生物和土壤微生物,是一种两亲分子,由短寡肽组成,脂肪酸尾部连接形成大环结构。对环十二肽活性的研究表明,环十二肽具有细胞毒性、抗菌和驱虫作用,被广泛应用于生物防治、药物开发、环境修复和疾病治疗等领域。环表肽类化合物在新药和药物先导化合物的开发中发挥着突出的作用,尤其是作为具有巨大药用潜力的抗生素,正慢慢渗入公众的视野。环十二肽的生物合成主要基于非核糖体肽合成酶的合成,以及利用基因工程和代谢工程方法选择同源物调控的关键调控酶和生物合成策略。这种生物合成方法具有微型化、可循环和更安全的特点。环十二肽的全合成方法主要是固液相结合法,这种方法合成环十二肽的速度较快,且易于纯化。本文综述了环表肽的生物活性、生物合成和全合成方法。
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引用次数: 0
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