Succession of the oral microbiome with the increasing severity of periodontitis

IF 9.7 4区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS VIEW Pub Date : 2024-02-01 DOI:10.1002/viw.20230118
Jun Mi, Mengfan Zhi, Wenyan Kang, Qianyu Liang, Di Tang, Ting Wang, Wenjing Song, Tianyong Sun, Meihui Li, Jinlong Shao, Shaohua Ge, Qiang Feng
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Abstract

Periodontitis development is strongly associated with the succession of the oral microbiome. However, the knowledge about the succession of the oral microbiome in the development of periodontitis remains insufficient. In the present study, an analysis was conducted on the succession of tongue back, the saliva (Sal) microbiome, and gingival crevicular fluid (GCF) from healthy individuals and patients with mild (CPL), moderate (CPM), severe chronic (CPH), and generalized aggressive periodontitis (GAgP). The composition and structure of the oral microbiome gradually changed with the increasing severity of periodontitis, among which GCF showed the highest correlation with periodontitis. With an ecological preference, pathogens in the mouth varied with the development of periodontitis. In healthy and CPL patients, Sal-derived microorganisms accounted for a large proportion of GCF but exhibited a decrease in patients with CPM, CPH, and GAgP. Permutation and time course sequencing analysis revealed that a variety of microorganisms changed with the severity of periodontitis. A majority of these microorganisms are closely related to clinical periodontal indices. Ecological analysis suggested that the composition of oral microbial communities at different stages of periodontitis is controlled by random processes. The comparison of microbial interaction networks demonstrated that a series of key microorganisms drive oral health to severe periodontitis. In this study, the relationship between the succession process of the oral microbiota and the development of periodontitis was revealed.
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口腔微生物群的继承与牙周炎严重程度的增加
牙周炎的发展与口腔微生物群的演替密切相关。然而,人们对牙周炎发展过程中口腔微生物群的演替的了解仍然不足。本研究分析了健康人和轻度牙周炎(CPL)、中度牙周炎(CPM)、重度慢性牙周炎(CPH)和全身侵袭性牙周炎(GAgP)患者的舌背、唾液(Sal)微生物群和牙龈缝隙液(GCF)的演替情况。口腔微生物组的组成和结构随着牙周炎严重程度的增加而逐渐发生变化,其中 GCF 与牙周炎的相关性最高。根据生态偏好,口腔中的病原体随着牙周炎的发展而变化。在健康和 CPL 患者中,盐源性微生物在 GCF 中占很大比例,但在 CPM、CPH 和 GAgP 患者中则有所减少。换位和时程测序分析表明,多种微生物会随着牙周炎的严重程度而发生变化。其中大部分微生物与临床牙周指数密切相关。生态学分析表明,牙周炎不同阶段的口腔微生物群落组成是由随机过程控制的。微生物相互作用网络的比较表明,一系列关键微生物驱动口腔健康走向严重牙周炎。本研究揭示了口腔微生物群的演替过程与牙周炎发展之间的关系。
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来源期刊
VIEW
VIEW Multiple-
CiteScore
12.60
自引率
2.30%
发文量
0
审稿时长
10 weeks
期刊介绍: View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.
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