Treatment of peri-implant mucositis: Adjunctive effect of glycine powder air polishing to professional mechanical biofilm removal. 12 months randomized clinical study

IF 3.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Implant Dentistry and Related Research Pub Date : 2024-02-05 DOI:10.1111/cid.13304
Discepoli Nicola DDS MSc PhD, De Rubertis Isabella DDS, Ciocci Carolina DDS, Nicola Baldini DDS PhD, Mirra Raffaele DDS
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Abstract

Introduction

To evaluate the adjunctive effect of glycine-powder air-polishing (GPAP) to full-mouth ultrasonic debridement (Fm-UD) in the treatment of peri-implant mucositis, and to determine the impact of implant and patient-level variables for disease resolution.

Methods

Individuals with a diagnosis of peri-implant mucositis were consecutively included in this randomized parallel arm clinical study. All the participants received a session of Fm-UD. Only implants allocated to the test group were additionally treated with GPAP. Clinical assessments were recorded at baseline, at 3 and at 12 months following intervention. The primary outcomes were complete disease resolution (DR1), defined as absence of bleeding sites at probing per implants, and partial disease resolution (DR2), measured as the presence of less than two bleeding sites at probing per implant. A final logistic multivariate regression model was built to evaluate the predictive role of implant and patient-level variables on DR.

Results

Fifty two patients and 157 implants were included. Both groups displayed significant reduction in the extent of bleeding on probing and plaque levels. At 12 months, DR1 was achieved in 16% and 27% of participants for the test and the control group respectively. IDR1 was best predicted by the number of bleeding sites (OR = 2.7, p = 0.04) and the greatest PPD value (OR = 2.7, p = 0.05), while IDR2 by the prosthetic connection (OR = 2.59, p = 0.02), the mean PPD (OR = 2.23, p = 0.04), the FMBS (OR = 4.09, p = 0.04), and number of implants (OR = 4.59, p = 0.02).

Conclusions

Despite significant improvements of clinical signs of peri-implant inflammation, the use of GPAP appears to have no adjunctive effect as compared with Fm-UD alone in the achievement of DR. Elevated initial levels of bleeding and PD predicted inferior likelihood of reaching disease resolution. The present randomized parallel arm clinical study was registered on Clinicaltrials.gov and received the following registration number: NCT05801315. This clinical trial was not registered prior to participant recruitment and randomization (https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009965&selectaction=Edit&uid=U0004FXM&ts=2&cx=fje7l8).

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种植体周围粘膜炎的治疗:甘氨酸粉末空气抛光对专业机械生物膜去除的辅助效果。为期12个月的随机临床研究。
简介评估甘氨酸粉末空气抛光术(GPAP)与全口超声波清创术(Fm-UD)在治疗种植体周围粘膜炎方面的辅助效果,并确定种植体和患者水平变量对疾病缓解的影响:这项随机平行臂临床研究连续纳入了被诊断为种植体周围粘膜炎的患者。所有参与者都接受了一次 Fm-UD 治疗。只有分配到试验组的种植体才额外接受了 GPAP 治疗。临床评估在基线、干预后 3 个月和 12 个月进行记录。主要结果是疾病完全缓解(DR1)和部分疾病缓解(DR2),前者的定义是每个种植体探诊时无出血点,后者的测量是每个种植体探诊时出血点少于两个。最后建立了一个逻辑多变量回归模型,以评估种植体和患者水平变量对 DR 的预测作用:共纳入 52 名患者和 157 个种植体。两组患者的探诊出血程度和牙菌斑水平均明显下降。12 个月后,测试组和对照组分别有 16% 和 27% 的参与者达到了 DR1。出血部位数量(OR = 2.7,p = 0.04)和最大 PPD 值(OR = 2.7,p = 0.05)对 IDR1 的预测效果最好,而修复体连接(OR = 2.59,p = 0.02)、平均 PPD(OR = 2.23,p = 0.04)、FMBS(OR = 4.09,p = 0.04)和种植体数量(OR = 4.59,p = 0.02)对 IDR2 的预测效果最好:尽管种植体周围炎症的临床症状有了明显改善,但与单独使用 Fm-UD 相比,使用 GPAP 似乎对实现 DR 没有辅助作用。初始出血和PD水平升高预示着疾病缓解的可能性较低。本随机平行臂临床研究已在 Clinicaltrials.gov 上注册,注册号如下:NCT05801315:NCT05801315。该临床试验在参与者招募和随机化之前并未注册(https://register.Clinicaltrials: gov/prs/app/action/SelectProtocol?sid=S0009965&selectaction=Edit&uid=U0004FXM&ts=2&cx=fje7l8)。
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来源期刊
CiteScore
6.00
自引率
13.90%
发文量
103
审稿时长
4-8 weeks
期刊介绍: The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.
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