Engineering Ultra-Small Cerium-Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease (Adv. Funct. Mater. 6/2024)

IF 5.1 Q1 POLYMER SCIENCE ACS Macro Letters Pub Date : 2024-02-05 DOI:10.1002/adfm.202470034

Zhongxing Chen, Zheng Li, Nana Tang, Yida Huang, Siheng Li, Wenjin Xu, Qing Wang, Xin Chen, Nan Zhao, Zhenhai Zeng, Yichen Xiao, Xinyi Chen, Jiawei Li, Xingtao Zhou, Guisheng Li, Mei Yang, Jinhai Huang

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Abstract

Ultrasmall Ce-MOFs Nanozymes

ln article number 2307569, Xingtao Zhou, Guisheng Li, Mei Yang, Jinhai Huang, and co-workers develop ultra-small cerium-based metal organic frameworks (Ce-MOFs) nanozymes for efficient antioxidative treatment of dry eye disease (DED). The obtained ultra-small Ce-MOF 3 (2 nm) exhibits superior ROS scavenging and antioxidant capacity, decreased cytotoxicity, and excellent ocular penetration. Therapeutically, Ce-MOF 3 is demonstrated to be highly efficient in alleviating DED by suppressing oxidative stress and inflammation, boosting corneal epithelial repair, and facilitating tear secretion recovery.

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设计超小型铈基金属有机框架纳米酶，用于干眼症的高效抗氧化治疗（Adv.）

超小型Ce-MOFs纳米酶ln文章编号：2307569，周兴涛、李桂生、杨梅、黄进海及其合作者开发了超小型铈基金属有机框架（Ce-MOFs）纳米酶，用于干眼病（DED）的高效抗氧化治疗。所获得的超小型 Ce-MOF 3（2 nm）具有卓越的清除 ROS 和抗氧化能力，降低了细胞毒性，并具有良好的眼部渗透性。在治疗方面，Ce-MOF 3 可抑制氧化应激和炎症反应，促进角膜上皮修复，促进泪液分泌恢复，从而有效缓解 DED。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.