{"title":"On the Biological Activity of a Gold-Containing Nanocomposite Based on Sulfated Carrageenan Polysaccharide","authors":"M. V. Zvereva, G. P. Aleksandrova, T. V. Fadeeva","doi":"10.1134/s2635167623600700","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The results of the synthesis of a biologically active nanostructured polymer system based on natural κ-carrageenan polysaccharide, which simultaneously acts as a reducing and stabilizing agent for emerging gold nanoparticles, are presented. The structure and nanomorphological characteristics of the resulting nanocomposite (in particular, in an aqueous solution), represented by κ-carrageenan stabilized Au<sup>0</sup> nanoparticles, the size of which varies in the range of 6–20 nm, are established using modern spectral (infrared and optical spectroscopy, dynamic light scattering) and microscopic (transmission electron microscopy) methods. It is for the first time established that the Au<sup>0</sup>NP/κ-CG-DP nanocomposite has pronounced anticoagulant activity, affecting the intrinsic and extrinsic blood-coagulation pathways.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2635167623600700","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
The results of the synthesis of a biologically active nanostructured polymer system based on natural κ-carrageenan polysaccharide, which simultaneously acts as a reducing and stabilizing agent for emerging gold nanoparticles, are presented. The structure and nanomorphological characteristics of the resulting nanocomposite (in particular, in an aqueous solution), represented by κ-carrageenan stabilized Au0 nanoparticles, the size of which varies in the range of 6–20 nm, are established using modern spectral (infrared and optical spectroscopy, dynamic light scattering) and microscopic (transmission electron microscopy) methods. It is for the first time established that the Au0NP/κ-CG-DP nanocomposite has pronounced anticoagulant activity, affecting the intrinsic and extrinsic blood-coagulation pathways.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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