Antiproliferative and Antibacterial Activity of Polyporoid Fungi from Veracruz, Mexico

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-02-01 DOI:10.1615/intjmedmushrooms.2024052840
Rosalba González-Solís, Guillermo Mendoza, Antero Ramos, Victor M. Bandala, Leticia Montoya, Aday González-Bakker, José M. Padrón, Irene Lagunes, Ángel Trigos
{"title":"Antiproliferative and Antibacterial Activity of Polyporoid Fungi from Veracruz, Mexico","authors":"Rosalba González-Solís, Guillermo Mendoza, Antero Ramos, Victor M. Bandala, Leticia Montoya, Aday González-Bakker, José M. Padrón, Irene Lagunes, Ángel Trigos","doi":"10.1615/intjmedmushrooms.2024052840","DOIUrl":null,"url":null,"abstract":"Polyporoid fungi represent a vast source of bioactive compounds with potential pharmacological applications. The importance of polyporoid fungi in TCM has led to an extensive use of some species of Ganoderma for promoting health and longevity because their consumption is associated with several bioactivities. Nevertheless, bioactivity of some other members of the Polyporaceae family has also been reported. This work reports the antiproliferative and antibacterial activity of crude extracts obtained from fruiting bodies of polypore fungi collected from the central region of Veracruz, Mexico, aimed at understanding the diversity of polypore species with potential pharmacological applications. 29 collections were identified macro- and microscopically in 19 species of polyporoid fungi, belonging to 13 genera. The antiproliferative activity screening of extracts against solid tumor cell lines (A549, SW1573, HeLa, HBL-100, T-47D and WiDr) allow us to identify four extracts with strong bioactivity (GI50= 50 μg/mL). Afterwards a phylogenetic analysis of DNA sequences from the ITS region obtained from bioactive specimens allowed us to identify three extracts as Pycnoporus sanguineus (GI50= 10 μg/mL) and the fourth bioactive extract as Ganoderma oerstedii (GI50= 50 μg/mL). Likewise, extracts from P. sanguineus showed mild or moderate antibacterial activity against Escherichia coli, Staphylococcus aureus and Xanthomonas albilineas. Bioprospecting studies of polyporoid fungi add to the knowledge of the diversity of macrofungi in Mexico and allow us to select one of the bioactive P. sanguineus to continue the pursuit of bioactive compounds through mycochemical studies.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of medicinal mushrooms","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1615/intjmedmushrooms.2024052840","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Polyporoid fungi represent a vast source of bioactive compounds with potential pharmacological applications. The importance of polyporoid fungi in TCM has led to an extensive use of some species of Ganoderma for promoting health and longevity because their consumption is associated with several bioactivities. Nevertheless, bioactivity of some other members of the Polyporaceae family has also been reported. This work reports the antiproliferative and antibacterial activity of crude extracts obtained from fruiting bodies of polypore fungi collected from the central region of Veracruz, Mexico, aimed at understanding the diversity of polypore species with potential pharmacological applications. 29 collections were identified macro- and microscopically in 19 species of polyporoid fungi, belonging to 13 genera. The antiproliferative activity screening of extracts against solid tumor cell lines (A549, SW1573, HeLa, HBL-100, T-47D and WiDr) allow us to identify four extracts with strong bioactivity (GI50= 50 μg/mL). Afterwards a phylogenetic analysis of DNA sequences from the ITS region obtained from bioactive specimens allowed us to identify three extracts as Pycnoporus sanguineus (GI50= 10 μg/mL) and the fourth bioactive extract as Ganoderma oerstedii (GI50= 50 μg/mL). Likewise, extracts from P. sanguineus showed mild or moderate antibacterial activity against Escherichia coli, Staphylococcus aureus and Xanthomonas albilineas. Bioprospecting studies of polyporoid fungi add to the knowledge of the diversity of macrofungi in Mexico and allow us to select one of the bioactive P. sanguineus to continue the pursuit of bioactive compounds through mycochemical studies.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
墨西哥韦拉克鲁斯多孔真菌的抗增殖和抗菌活性
多孔真菌是具有潜在药理应用价值的生物活性化合物的巨大来源。由于多孔真菌在中医中的重要性,灵芝的一些种类被广泛用于促进健康和延年益寿,因为食用灵芝具有多种生物活性。然而,多孔菌科其他一些成员的生物活性也有报道。本研究报告了从墨西哥韦拉克鲁斯中部地区采集的多孔真菌子实体中提取的粗提取物的抗增殖和抗菌活性,旨在了解具有潜在药理应用价值的多孔真菌物种的多样性。通过宏观和显微镜鉴定了隶属于 13 个属的 19 种多孔真菌中的 29 个藏品。通过对实体瘤细胞系(A549、SW1573、HeLa、HBL-100、T-47D 和 WiDr)进行抗增殖活性筛选,我们确定了四种生物活性较强的提取物(GI50= 50 μg/mL)。随后,通过对从生物活性标本中获得的 ITS 区域 DNA 序列进行系统进化分析,我们确定三种提取物为 Pycnoporus sanguineus(GI50= 10 μg/mL),第四种生物活性提取物为 Ganoderma oerstedii(GI50= 50 μg/mL)。同样,山苍子提取物对大肠杆菌、金黄色葡萄球菌和白血黄单胞菌具有轻度或中度抗菌活性。对多孔真菌的生物勘探研究增加了我们对墨西哥大型真菌多样性的了解,并使我们能够选择其中一种具有生物活性的 P. sanguineus,通过真菌化学研究继续寻找生物活性化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
期刊最新文献
Methanolic Extract of Morchella esculenta (Ascomycota), Prevents Chemotherapy Related Cardiotoxicity in Tumour Bearing Mice Optimization of Mycelial Growth Parameters in Lion’s Mane Edible Medicinal Mushroom Hericium erinaceus (Agaricomycetes) by Supplementation of Growth Hormones Hot Water Extract of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body Activates Myeloid Dendritic Cells through a Dectin-1-Mediated Pathway Enhancement of Cordycepin Production Through Liquid Static Fermentation of Caterpillar Medicinal Mushroom Cordycep militaris (Ascomycetes) Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Stress and Selective Fitness Profile Parameters in Female College Students in West Bengal, India
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1