Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon
{"title":"Observational Study of the Changes in Skin Thickness Among Children with Atopic Dermatitis Treated with Topical Mometasone Furoate 0.1% Cream","authors":"Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon","doi":"10.5812/jssc-139473","DOIUrl":null,"url":null,"abstract":"Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"151 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Skin and Stem Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/jssc-139473","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P
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