{"title":"Crisaborole in Atopic Dermatitis","authors":"Farheen Begum, Monis Khan","doi":"10.5812/jssc-146756","DOIUrl":"https://doi.org/10.5812/jssc-146756","url":null,"abstract":"<jats:p/>","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Morbihan disease (MD) is a rare and infrequent condition primarily affecting adults of both sexes in their third and fourth decades of life. Patients with MD typically present with asymptomatic, recurrent bilateral symmetrical pitting edema, which has an insidious onset and a progressive course. This edema affects the upper two-thirds of the face, including the forehead, glabella, periorbital area, cheeks, and nose, with or without erythema. Over time, it evolves into persistent solid, non-pitting, asymptomatic edema that is neither painful nor pruritic. Morbihan disease may cause facial contour deformity and sometimes narrowing of the visual field. The etiopathogenesis of MD remains unknown, and currently, there is no specific treatment for the condition. This review article provides an update on MD, aiming to increase awareness and knowledge about its etiopathogenesis and management.
{"title":"An Update on the Etiopathogenesis and Management of Morbihan Disease: A Narrative Review","authors":"Mohammed Abu El-Hamd, Soha Aboeldahab","doi":"10.5812/jssc-146014","DOIUrl":"https://doi.org/10.5812/jssc-146014","url":null,"abstract":": Morbihan disease (MD) is a rare and infrequent condition primarily affecting adults of both sexes in their third and fourth decades of life. Patients with MD typically present with asymptomatic, recurrent bilateral symmetrical pitting edema, which has an insidious onset and a progressive course. This edema affects the upper two-thirds of the face, including the forehead, glabella, periorbital area, cheeks, and nose, with or without erythema. Over time, it evolves into persistent solid, non-pitting, asymptomatic edema that is neither painful nor pruritic. Morbihan disease may cause facial contour deformity and sometimes narrowing of the visual field. The etiopathogenesis of MD remains unknown, and currently, there is no specific treatment for the condition. This review article provides an update on MD, aiming to increase awareness and knowledge about its etiopathogenesis and management.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Acne is a common skin condition characterized by chronic inflammation of the pilosebaceous unit. Increased sebum production is a key component of acne pathogenesis. Various therapies are available for acne, including topical, systemic, and physical treatments. Botulinum toxin is increasingly used in facial cosmetic procedures. Observations suggest that botulinum toxin type A (BoNT-A) may reduce sebum levels in the face. This finding could potentially lead to the development of a new treatment for oily skin and acne. Evidence Acquisition: A retrospective literature review was conducted by searching the PubMed, Web of Science, EMBASE, and SCOPUS databases using keywords such as "acne," "acne treatment," "oily skin," and "botulinum toxin type A." The review focused on studies that assessed the impact of BoNT-A on patients with acne vulgaris and oily skin, as well as studies that measured skin sebum levels and pore size following BoNT-A application. Results: Nine studies were reviewed. Of these, two evaluated the effects of BoNT-A on 30 and 35 patients with acne vulgaris. Four studies assessed sebum reduction in 20, 50, 42, and 20 patients. Three studies evaluated both sebum reduction and pore size tightening in 10, 25, and 20 patients. Eight studies demonstrated that the application of BoNT-A has a positive effect on patients with acne and reduces sebum production in facial skin. Only one study, which evaluated both sebum reduction and pore size tightening, found no significant effect. Overall, the studies indicate that BoNT-A application can positively impact acne and reduce facial sebum production. Specifically, intradermal application of BoNT-A at low dosages can help reduce acne, sebum production, and tighten pores. Conclusions: BoNT-A shows promise as a treatment for acne and oily skin. While cost-effectiveness may be a challenge for some patients, the benefits of BoNT-A make it a treatment option worth considering. With further studies to optimize dosages and determine the longest duration of efficacy, BoNT-A has the potential to revolutionize the treatment of acne and oily skin.
{"title":"Facial Acne Management and Sebum Reduction via Botulinum Toxin Type A Treatment: A Review","authors":"Serap Maden","doi":"10.5812/jssc-145639","DOIUrl":"https://doi.org/10.5812/jssc-145639","url":null,"abstract":"Context: Acne is a common skin condition characterized by chronic inflammation of the pilosebaceous unit. Increased sebum production is a key component of acne pathogenesis. Various therapies are available for acne, including topical, systemic, and physical treatments. Botulinum toxin is increasingly used in facial cosmetic procedures. Observations suggest that botulinum toxin type A (BoNT-A) may reduce sebum levels in the face. This finding could potentially lead to the development of a new treatment for oily skin and acne. Evidence Acquisition: A retrospective literature review was conducted by searching the PubMed, Web of Science, EMBASE, and SCOPUS databases using keywords such as \"acne,\" \"acne treatment,\" \"oily skin,\" and \"botulinum toxin type A.\" The review focused on studies that assessed the impact of BoNT-A on patients with acne vulgaris and oily skin, as well as studies that measured skin sebum levels and pore size following BoNT-A application. Results: Nine studies were reviewed. Of these, two evaluated the effects of BoNT-A on 30 and 35 patients with acne vulgaris. Four studies assessed sebum reduction in 20, 50, 42, and 20 patients. Three studies evaluated both sebum reduction and pore size tightening in 10, 25, and 20 patients. Eight studies demonstrated that the application of BoNT-A has a positive effect on patients with acne and reduces sebum production in facial skin. Only one study, which evaluated both sebum reduction and pore size tightening, found no significant effect. Overall, the studies indicate that BoNT-A application can positively impact acne and reduce facial sebum production. Specifically, intradermal application of BoNT-A at low dosages can help reduce acne, sebum production, and tighten pores. Conclusions: BoNT-A shows promise as a treatment for acne and oily skin. While cost-effectiveness may be a challenge for some patients, the benefits of BoNT-A make it a treatment option worth considering. With further studies to optimize dosages and determine the longest duration of efficacy, BoNT-A has the potential to revolutionize the treatment of acne and oily skin.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"82 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Humans have engaged in various beliefs, attitudes, actions, and medical procedures to enhance their physical attractiveness. This pursuit has led to several psychodermatological disorders, including charismaphobia, which is the fear of becoming unattractive. Objectives: Offering fresh perspectives to mental health practitioners and cosmetic dermatologists, the current study addresses a significant gap in knowledge by exploring the gender-specific dynamics of charismaphobia in relation to body esteem and self-esteem. Methods: The survey involved 879 conveniently selected participants, including both men (n = 261) and women (n = 618). The Charismaphobia Scale, Body-Esteem Scale, and Self-Esteem Scale were used, along with a demographic information questionnaire. Results: Women exhibited significantly higher levels of charismaphobia compared to men (Men = 52.53%; Women = 68.04%; P = 0.000; Cohen’s d = 0.710). Conversely, men demonstrated significantly greater body-esteem (Men = 80.03%; Women = 70.37%; P = 0.000; Cohen’s d = 1.040) and self-esteem (Men = 68.85%; Women = 53.69%; P = 0.000; Cohen’s d = 0.985) compared to women. A significant inverse correlation was identified between charismaphobia and both body-esteem (r = -.329; P < 0.01) and self-esteem (r = -.608; P < 0.01). In both men and women, self-esteem had a stronger impact on charismaphobia than vice versa (P < 0.01). The findings affirmed the greater relevance of self-esteem in influencing charismaphobia compared to body-esteem (P < 0.01). Conclusions: The current study highlights the unfair pressure placed on women to meet societal standards of beauty, explaining why charismaphobia is gender-specific. The study recommends embracing one's multifaceted identity, beyond physical appearance, to cultivate robust self-esteem and avoid the detrimental effects of charismaphobia. It emphasizes the fundamental roles of self-esteem and body-esteem in this process.
背景：人类通过各种信念、态度、行动和医疗程序来提高自己的外貌吸引力。这种追求导致了多种皮肤心理疾病，包括魅力恐惧症，即害怕自己变得没有吸引力。目标：本研究为心理健康从业者和美容皮肤科医生提供了新的视角，通过探讨魅力恐怖症与身体自尊和自重的性别特异性动态关系，填补了知识上的重大空白。调查方法调查对象为方便挑选的 879 名参与者，包括男性（n = 261）和女性（n = 618）。调查使用了魅力恐怖量表、身体自尊量表和自尊量表，以及人口统计学信息问卷。结果显示与男性相比，女性的魅力恐惧程度明显更高（男性 = 52.53%；女性 = 68.04%；P = 0.000；Cohen's d = 0.710）。相反，男性的身体自尊（男性 = 80.03%；女性 = 70.37%；P = 0.000；Cohen's d = 1.040）和自尊（男性 = 68.85%；女性 = 53.69%；P = 0.000；Cohen's d = 0.985）明显高于女性。魅力恐怖症与身体自尊（r = -.329; P < 0.01）和自尊（r = -.608; P < 0.01）之间存在明显的反相关关系。在男性和女性中，自尊对魅力恐怖症的影响比反之更大（P < 0.01）。研究结果证实，与身体自尊相比，自尊对魅力恐怖症的影响更大（P < 0.01）。结论：当前的研究强调了女性为满足社会对美的标准而承受的不公平压力，这也解释了为什么魅力恐怖症具有性别特异性。这项研究建议，除了外貌之外，还要拥抱自己多方面的身份，以培养强大的自尊心，避免魅力恐惧症的有害影响。它强调了自尊和身体自尊在这一过程中的基本作用。
{"title":"The Gender-Specific Dynamics of Charismaphobia in Relation to Body-Esteem and Self-Esteem: Implications for Cosmetic and Psycho-Dermatology","authors":"Waqar Husain, Maha Nasir Malik","doi":"10.5812/jssc-145103","DOIUrl":"https://doi.org/10.5812/jssc-145103","url":null,"abstract":"Background: Humans have engaged in various beliefs, attitudes, actions, and medical procedures to enhance their physical attractiveness. This pursuit has led to several psychodermatological disorders, including charismaphobia, which is the fear of becoming unattractive. Objectives: Offering fresh perspectives to mental health practitioners and cosmetic dermatologists, the current study addresses a significant gap in knowledge by exploring the gender-specific dynamics of charismaphobia in relation to body esteem and self-esteem. Methods: The survey involved 879 conveniently selected participants, including both men (n = 261) and women (n = 618). The Charismaphobia Scale, Body-Esteem Scale, and Self-Esteem Scale were used, along with a demographic information questionnaire. Results: Women exhibited significantly higher levels of charismaphobia compared to men (Men = 52.53%; Women = 68.04%; P = 0.000; Cohen’s d = 0.710). Conversely, men demonstrated significantly greater body-esteem (Men = 80.03%; Women = 70.37%; P = 0.000; Cohen’s d = 1.040) and self-esteem (Men = 68.85%; Women = 53.69%; P = 0.000; Cohen’s d = 0.985) compared to women. A significant inverse correlation was identified between charismaphobia and both body-esteem (r = -.329; P < 0.01) and self-esteem (r = -.608; P < 0.01). In both men and women, self-esteem had a stronger impact on charismaphobia than vice versa (P < 0.01). The findings affirmed the greater relevance of self-esteem in influencing charismaphobia compared to body-esteem (P < 0.01). Conclusions: The current study highlights the unfair pressure placed on women to meet societal standards of beauty, explaining why charismaphobia is gender-specific. The study recommends embracing one's multifaceted identity, beyond physical appearance, to cultivate robust self-esteem and avoid the detrimental effects of charismaphobia. It emphasizes the fundamental roles of self-esteem and body-esteem in this process.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon
Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P
{"title":"Observational Study of the Changes in Skin Thickness Among Children with Atopic Dermatitis Treated with Topical Mometasone Furoate 0.1% Cream","authors":"Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon","doi":"10.5812/jssc-139473","DOIUrl":"https://doi.org/10.5812/jssc-139473","url":null,"abstract":"Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139868260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon
Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P
{"title":"Observational Study of the Changes in Skin Thickness Among Children with Atopic Dermatitis Treated with Topical Mometasone Furoate 0.1% Cream","authors":"Wai Quen Lee, Kishore Manogalan, Pik Li Wong, Che Zubaidah Che Daud, Sabeera Begum Kader Ibrahim, Leong Kin Fon","doi":"10.5812/jssc-139473","DOIUrl":"https://doi.org/10.5812/jssc-139473","url":null,"abstract":"Background: Atopic dermatitis (AD) affects up to 20% of children worldwide and, as of now, it has no cure. The primary treatment for AD in children involves the use of topical corticosteroids. Objectives: Our objective was to evaluate the potential for skin atrophy caused by the application of mometasone furoate 0.1% cream in children with moderate to severe AD. Methods: This study was a single-center, prospective cohort study involving 22 children aged 6-12 years with moderate to severe AD. The children applied topical mometasone furoate 0.1% cream for 6 weeks in a non-occlusive manner. We conducted dermoscopic and ultrasonographic assessments of skin atrophy at 0, 2, and 6 weeks into the treatment. Results: All patients exhibited an improvement in skin erythema. At the beginning of the study, 91% of the patients had mild to moderate erythema, while 9.1% had severe erythema. After 6 weeks of using topical mometasone, 27.3% had mild erythema, and 72.7% had completely resolved erythema (P","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"151 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139808091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bleomycin Tatooing for Periungual Verruca","authors":"S. Rambhia","doi":"10.5812/jssc-143299","DOIUrl":"https://doi.org/10.5812/jssc-143299","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"60 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138968051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Ali Nilforoushzadeh, Hanieh Azizi, E. Taghiabadi, Mohammad Amir Amirkhani
{"title":"Extracellular Vesicles (EVs) as a New Treatment for Melanoma","authors":"Mohammad Ali Nilforoushzadeh, Hanieh Azizi, E. Taghiabadi, Mohammad Amir Amirkhani","doi":"10.5812/jssc-141515","DOIUrl":"https://doi.org/10.5812/jssc-141515","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atul Rajeendran, M. M. Shenoy, Malcolm Pinto, Vishal B Amin, S. Hegde, Amina Asfiya, A. Razak
Background: Palmoplantar keratodermas (PPK) represents a group of skin disorders characterized by excessive epidermal thickening of palms and soles. They are classically divided into inherited and acquired groups. Dermoscopy is a non-invasive procedure that can aid in the clinical diagnosis of PPK. Objectives: To study the clinical features and dermoscopic patterns of PPK caused by various dermatological conditions. Methods: Ninety-eight patients with various types of PPK were included in this cross-sectional observational study after obtaining informed consent. Symptoms, general systemic findings, and dermatological manifestations were recorded. The dermoscopic examination was performed by a single observer using Heine Delta 20+ and FotoFinder Medicam 1000. Diagnostically challenging cases were biopsied for histopathological examination. SPSS (Statistical Package for Social Sciences) version 20 [IBM SPSS statistics (IBM Corp. Armonk, NY, USA released 2011)] was used to perform statistical analyses. The chi-square test was applied to examine statistical associations between qualitative variables. The level of significance was set at 5%. Results: Out of 98 cases with PPK, 93 were acquired, and 5 were inherited. The commonest dermoscopy pattern included palmoplantar psoriasis (n = 48), showing a background light red color with yellow diffused white scales with regular dotted and glomerular vessels, followed by palmoplantar eczema (n = 39) (light red color with yellow patchy white background, yellow scales, and patchy dotted vessels). Light red/dull red background with diffuse white scaling and regular linear, dotted, or glomerular vessels were significantly in favor of palmoplantar psoriasis, while a yellow background, diffuse yellow scaling, patchy dotted vessels, and yellow crust were more in favor of palmoplantar dermatitis. Pityriasis rubra pilaris (PRP) (n = 3) showed a light red background, diffused white scales, and dotted and linear vessels with patchy distribution. Lichen planus (n = 2) revealed a light red color with a yellow background, diffused and peripheral white scales, and irregular linear (radial) and dotted vessels. Wickham’s striae were found on palms. Tinea manuum with pedis (n = 1) showed a dull red background and diffused white and yellow scales with the localization of the scales in the skin furrows. PPK secondary to ichthyosis vulgaris (n = 3) revealed a light red background with diffused white and yellow patchy scaling and regular linear and patchy glomerular vessels. Greither’s disease showed a light red color with a yellow background, a diffused white scale pattern, and multiple dotted vessels arranged in an irregular pattern. Erythrokeratodermia variabilis showed a background color of light red and diffused white scales in a crisscross pattern. Conclusions: Dermoscopy can reveal characteristic but not pathognomonic dermoscopic patterns that can be useful in the clinical diagnosis of various types of PPK. More studies wit
{"title":"Clinical and Dermoscopic Studying of Palmoplantar Keratodermas","authors":"Atul Rajeendran, M. M. Shenoy, Malcolm Pinto, Vishal B Amin, S. Hegde, Amina Asfiya, A. Razak","doi":"10.5812/jssc-140213","DOIUrl":"https://doi.org/10.5812/jssc-140213","url":null,"abstract":"Background: Palmoplantar keratodermas (PPK) represents a group of skin disorders characterized by excessive epidermal thickening of palms and soles. They are classically divided into inherited and acquired groups. Dermoscopy is a non-invasive procedure that can aid in the clinical diagnosis of PPK. Objectives: To study the clinical features and dermoscopic patterns of PPK caused by various dermatological conditions. Methods: Ninety-eight patients with various types of PPK were included in this cross-sectional observational study after obtaining informed consent. Symptoms, general systemic findings, and dermatological manifestations were recorded. The dermoscopic examination was performed by a single observer using Heine Delta 20+ and FotoFinder Medicam 1000. Diagnostically challenging cases were biopsied for histopathological examination. SPSS (Statistical Package for Social Sciences) version 20 [IBM SPSS statistics (IBM Corp. Armonk, NY, USA released 2011)] was used to perform statistical analyses. The chi-square test was applied to examine statistical associations between qualitative variables. The level of significance was set at 5%. Results: Out of 98 cases with PPK, 93 were acquired, and 5 were inherited. The commonest dermoscopy pattern included palmoplantar psoriasis (n = 48), showing a background light red color with yellow diffused white scales with regular dotted and glomerular vessels, followed by palmoplantar eczema (n = 39) (light red color with yellow patchy white background, yellow scales, and patchy dotted vessels). Light red/dull red background with diffuse white scaling and regular linear, dotted, or glomerular vessels were significantly in favor of palmoplantar psoriasis, while a yellow background, diffuse yellow scaling, patchy dotted vessels, and yellow crust were more in favor of palmoplantar dermatitis. Pityriasis rubra pilaris (PRP) (n = 3) showed a light red background, diffused white scales, and dotted and linear vessels with patchy distribution. Lichen planus (n = 2) revealed a light red color with a yellow background, diffused and peripheral white scales, and irregular linear (radial) and dotted vessels. Wickham’s striae were found on palms. Tinea manuum with pedis (n = 1) showed a dull red background and diffused white and yellow scales with the localization of the scales in the skin furrows. PPK secondary to ichthyosis vulgaris (n = 3) revealed a light red background with diffused white and yellow patchy scaling and regular linear and patchy glomerular vessels. Greither’s disease showed a light red color with a yellow background, a diffused white scale pattern, and multiple dotted vessels arranged in an irregular pattern. Erythrokeratodermia variabilis showed a background color of light red and diffused white scales in a crisscross pattern. Conclusions: Dermoscopy can reveal characteristic but not pathognomonic dermoscopic patterns that can be useful in the clinical diagnosis of various types of PPK. More studies wit","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"22 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Eosinophils are multifunctional cells of innate immunity and play a pivotal role in allergic, antiparasitic, phagocytotic, and tissue repair functions. These cells are sentinel mediators of pruritus. The increase in the absolute eosinophil count (AEC) in pruritic dermatoses is considered an objective marker of disease severity. The dermatology life quality index (DLQI) is a questionnaire assessing subjective impairment in quality of life. Objectives: To assess the correlation between AEC and DLQI in pruritic dermatoses. Methods: This cross-sectional observational-correlational study was carried out over a period of 6 months in a tertiary care center on 100 patients diagnosed with various clinical forms of pruritic dermatoses after obtaining informed consent. The DLQI score was calculated using a pre-validated questionnaire followed by the determination of AEC in whole blood samples. Results: Most patients had inflammatory diseases (26%), followed by infections (16%) and urticaria (14%). Mild eosinophilia was observed in 28% of cases, moderate eosinophilia in 22%, and severe eosinophilia in 6% of the cases. In terms of the DLQI score, the impact of the disease on quality of life was profound in 37% of the patients and enormous among 12% of them. Quality of life was unaffected in 5% of the cases. Overall, there was a significant strong positive correlation between AEC and DLQI (r = 0.649, P < 0.0001). Conclusions: A significant correlation was noticed between AEC and subjective DLQI as a marker of disease burden in various forms of pruritic dermatoses. Thus, AEC can be regarded as a perceived marker of disease prognostication, an objective equivalent to quality of life, and, most importantly, a potential target for therapeutic interventions.
背景:嗜酸性粒细胞是先天性免疫的多功能细胞，在过敏、抗寄生虫、吞噬和组织修复等功能中发挥着重要作用。这些细胞是瘙痒的前哨介质。瘙痒性皮肤病中嗜酸性粒细胞绝对计数(AEC)的增加被认为是疾病严重程度的客观标志。皮肤科生活质量指数(DLQI)是一种评估主观生活质量损害的问卷调查。目的:探讨瘙痒性皮肤病AEC与DLQI的相关性。方法:本横断面观察相关性研究是在一家三级医疗中心对100名经知情同意后诊断为各种临床形式瘙痒性皮肤病的患者进行为期6个月的研究。DLQI评分采用预先验证的问卷计算，然后测定全血样本中的AEC。结果:以炎症性疾病为主(26%)，其次为感染(16%)和荨麻疹(14%)。轻度嗜酸性粒细胞增多的病例占28%，中度嗜酸性粒细胞增多的病例占22%，重度嗜酸性粒细胞增多的病例占6%。在DLQI评分方面，疾病对生活质量的影响在37%的患者中是深刻的，在12%的患者中是巨大的。5%的患者的生活质量未受影响。总体而言，AEC与DLQI呈正相关(r = 0.649, P < 0.0001)。结论:在各种形式的瘙痒性皮肤病中，AEC和主观DLQI作为疾病负担的标志之间存在显著的相关性。因此，AEC可被视为疾病预后的感知标记，客观等同于生活质量，最重要的是，它是治疗干预的潜在目标。
{"title":"Peripheral Eosinophilia as an Ominous Marker of Poor Quality of Life: A Cross-Sectional Study Evaluating the Correlation Between Absolute Eosinophilia and Dermatology Life Quality Index in Various Pruritic Dermatoses","authors":"Vijay Deepak Joshi, V. Belgaumkar, S. Pradhan","doi":"10.5812/jssc-139132","DOIUrl":"https://doi.org/10.5812/jssc-139132","url":null,"abstract":"Background: Eosinophils are multifunctional cells of innate immunity and play a pivotal role in allergic, antiparasitic, phagocytotic, and tissue repair functions. These cells are sentinel mediators of pruritus. The increase in the absolute eosinophil count (AEC) in pruritic dermatoses is considered an objective marker of disease severity. The dermatology life quality index (DLQI) is a questionnaire assessing subjective impairment in quality of life. Objectives: To assess the correlation between AEC and DLQI in pruritic dermatoses. Methods: This cross-sectional observational-correlational study was carried out over a period of 6 months in a tertiary care center on 100 patients diagnosed with various clinical forms of pruritic dermatoses after obtaining informed consent. The DLQI score was calculated using a pre-validated questionnaire followed by the determination of AEC in whole blood samples. Results: Most patients had inflammatory diseases (26%), followed by infections (16%) and urticaria (14%). Mild eosinophilia was observed in 28% of cases, moderate eosinophilia in 22%, and severe eosinophilia in 6% of the cases. In terms of the DLQI score, the impact of the disease on quality of life was profound in 37% of the patients and enormous among 12% of them. Quality of life was unaffected in 5% of the cases. Overall, there was a significant strong positive correlation between AEC and DLQI (r = 0.649, P < 0.0001). Conclusions: A significant correlation was noticed between AEC and subjective DLQI as a marker of disease burden in various forms of pruritic dermatoses. Thus, AEC can be regarded as a perceived marker of disease prognostication, an objective equivalent to quality of life, and, most importantly, a potential target for therapeutic interventions.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124573443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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