Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.

IF 4.4 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES npj Microgravity Pub Date : 2024-02-27 DOI:10.1038/s41526-024-00366-8
Matteo Fois, Ana Diaz-Artiles, Syeda Yasmin Zaman, Luca Ridolfi, Stefania Scarsoglio
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Abstract

Head-down tilt (HDT) has been widely proposed as a terrestrial analog of microgravity and used also to investigate the occurrence of spaceflight-associated neuro-ocular syndrome (SANS), which is currently considered one of the major health risks for human spaceflight. We propose here an in vivo validated numerical framework to simulate the acute ocular-cerebrovascular response to 6° HDT, to explore the etiology and pathophysiology of SANS. The model links cerebral and ocular posture-induced hemodynamics, simulating the response of the main cerebrovascular mechanisms, as well as the relationship between intracranial and intraocular pressure to HDT. Our results from short-term (10 min) 6° HDT show increased hemodynamic pulsatility in the proximal-to-distal/capillary-venous cerebral direction, a marked decrease (-43%) in ocular translaminar pressure, and an increase (+31%) in ocular perfusion pressure, suggesting a plausible explanation of the underlying mechanisms at the onset of ocular globe deformation and edema formation over longer time scales.

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通过硅胶-体内头朝下倾斜框架将大脑血流动力学和眼球微重力诱导的改变联系起来。
头朝下倾斜(HDT)被广泛认为是地面微重力的一种类似物,也被用于研究与航天相关的神经-眼综合征(SANS)的发生,该综合征目前被认为是人类航天飞行的主要健康风险之一。我们在此提出了一个经过活体验证的数值框架,用于模拟 6° HDT 的急性眼-脑血管反应,以探索 SANS 的病因和病理生理学。该模型将脑部和眼部姿势引起的血流动力学联系起来,模拟主要脑血管机制的反应,以及颅内压和眼内压与 HDT 的关系。我们对短期(10 分钟)6° HDT 的研究结果表明,大脑近端到远端/毛细血管-静脉方向的血流动力学搏动性增加,眼球层压明显降低(-43%),眼球灌注压增加(+31%),这表明在较长的时间尺度上,眼球变形和水肿形成的潜在机制是可以解释的。
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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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