The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-03-05 DOI:10.1002/oby.23999

Takahiro Ichikawa, Hiroshi Okada, Masahide Hamaguchi, Norihiro Nishioka, Yukiko Tateyama, Tomonari Shimamoto, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Taku Iwami, Michiaki Fukui

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Abstract

Objective

The study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.

Methods

All 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events was observed for 11 years. The main outcome was 3-point major adverse cardiac events (MACE), which comprises cardiovascular death, nonfatal coronary artery disease, and nonfatal stroke incidence.

Results

Of the participants, 2748 (2.3%) cases of 3-point MACE were identified during follow-up. The stable metabolically healthy obesity group had a higher risk of 3-point MACE than those with stable metabolically healthy nonobesity (MHNO). Additionally, the change from metabolically healthy obesity to MHNO for 2 years decreased the risk of 3-point MACE (hazard ratio [HR], 1.12: 95% CI: 0.84–1.47) to the same level as stable MHNO. However, the change from metabolically abnormal nonobesity and metabolically abnormal obesity to MHNO for 2 years maintained a higher risk of 3-point MACE (HR, 1.66 [95% CI: 1.36–2.01]; HR, 1.91 [95% CI: 1.22–2.81]) than those with stable MHNO.

Conclusions

Change in metabolic phenotype is associated with incident 3-point MACE.

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代谢表型的转变与心血管事件：松下队列研究 16.

研究目的研究目的是探讨代谢表型的变化是否会影响心血管事件的风险：这项回顾性队列研究共纳入了 117589 名参与者。在两个时间点对参与者的代谢表型进行了评估（第二次评估设定在第一次评估的两年后），并对心血管事件的发生率进行了长达 11 年的观察。主要结果是3点主要心脏不良事件（MACE），包括心血管死亡、非致命性冠状动脉疾病和非致命性中风发病率：结果：在随访期间，参与者中有 2748 例（2.3%）发生了 3 点 MACE。代谢健康的稳定肥胖组发生 3 点 MACE 的风险高于代谢健康的非稳定肥胖组（MHNO）。此外，从代谢健康肥胖转变为代谢健康非肥胖 2 年后，3 点 MACE 风险降低（危险比 [HR]，1.12：95% CI：0.84-1.47）至与稳定代谢健康非肥胖相同的水平。然而，从代谢异常的非肥胖和代谢异常的肥胖转变为持续2年的MHNO的患者发生3点MACE的风险（HR，1.66 [95% CI：1.36-2.01]；HR，1.91 [95% CI：1.22-2.81]）仍高于稳定的MHNO患者：代谢表型的变化与3点MACE事件有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.