{"title":"The trends and incidence of alcohol-associated hepatitis hospitalizations from 2016–2020 and the impact of the COVID-19 pandemic","authors":"Megan B. Ghai , Pooja Rangan , Naim Alkhouri , Jessica Mellinger , Karn Wijarnpreecha","doi":"10.1016/j.alcohol.2024.03.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016 to 2020 and evaluate demographic disparities including sex and race.</div></div><div><h3>Methods</h3><div>A retrospective analysis of the 2016–2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.</div></div><div><h3>Results</h3><div>Included were 607 140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016 to 2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100 000 all-cause discharges per year between 2016 and 2019 and increased to 113 hospitalizations per 100 000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016–2019 (aOR = 1.28, <em>p</em> < 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR = 2.71, <em>p</em> < 0.001).</div></div><div><h3>Discussion</h3><div>Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol use disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 177-184"},"PeriodicalIF":2.5000,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0741832924000399","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016 to 2020 and evaluate demographic disparities including sex and race.
Methods
A retrospective analysis of the 2016–2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.
Results
Included were 607 140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016 to 2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100 000 all-cause discharges per year between 2016 and 2019 and increased to 113 hospitalizations per 100 000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016–2019 (aOR = 1.28, p < 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR = 2.71, p < 0.001).
Discussion
Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol use disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.
期刊介绍:
Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects.
Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.