THE TRENDS AND INCIDENCE OF ALCOHOL-ASSOCIATED HEPATITIS HOSPITALIZATIONS FROM 2016-2020 AND THE IMPACT OF THE COVID-19 PANDEMIC.

Megan B Ghai, Pooja Rangan, Naim Alkhouri, Jessica Mellinger, Karn Wijarnpreecha
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Abstract

Introduction: The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016-2020 and evaluate demographic disparities including sex and race.

Methods: A retrospective analysis of the 2016-2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.

Results: Included were 607,140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016-2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100,000 all-cause discharges per year between 2016-2019 and increased to 113 hospitalizations per 100,000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016-2019 (aOR= 1.28, p < 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR= 2.71, p <0.001).

Discussion: Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol used disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.

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2016-2020 年酒精相关肝炎住院治疗的趋势和发病率,以及 covid-19 大流行的影响。
导言:人们对 COVID-19 大流行对酒精相关性肝炎(AH)住院治疗的影响知之甚少。在此,我们探讨了 2016-2020 年酒精相关性肝炎的发展趋势,并评估了包括性别和种族在内的人口统计学差异:方法:我们对 2016-2020 年医疗成本与利用项目全国住院患者样本进行了回顾性分析,以评估 AH 住院治疗的时间趋势。对 2020 年的数据集进行了评估,以比较有 COVID-19 附加诊断和没有 COVID-19 附加诊断的 AH 住院情况:结果:2016-2020年间,每145,055,152例全因出院病例中有607,140例加权AH住院病例。2016-2019 年间,AH 住院率以每年每 10 万例全因出院患者 23.4 例的速度增长,到 2020 年将增至每 10 万例全因出院患者 113 例。尽管住院率低于男性,但女性的死亡率更高。2020 年调整后的 AH 住院几率高于 2016-2019 年(aOR= 1.28,p <0.001)。与其他种族相比,西班牙裔人群因 AH 和 COVID-19 住院的几率更高(aOR= 2.71,p 讨论):需要加大力度对过度饮酒进行初级预防,并为酗酒者提供更多的社会支持。需要开展更多研究,以阐明西语裔人群中酗酒和 COVID-19 的种族差异。
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