Wen-Chao Gao, Wei Li, Juan Zhang, Hong-Hong Chang, Rong Zhou
{"title":"Mild and green thioacylation with dithiocarboxylates via photoredox catalysis","authors":"Wen-Chao Gao, Wei Li, Juan Zhang, Hong-Hong Chang, Rong Zhou","doi":"10.1016/j.gresc.2024.02.008","DOIUrl":null,"url":null,"abstract":"<div><div>A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent. The key to the success of this transformation is the light-induced generation of active dithioacyl disulfides as thioacyl donors. This green methodology has been successfully employed for the late-stage thioacylation of various amino compounds including drugs, hormones, amino acids and peptides under mild conditions.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"7 1","pages":"Pages 69-74"},"PeriodicalIF":0.0000,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Synthesis and Catalysis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666554924000280","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent. The key to the success of this transformation is the light-induced generation of active dithioacyl disulfides as thioacyl donors. This green methodology has been successfully employed for the late-stage thioacylation of various amino compounds including drugs, hormones, amino acids and peptides under mild conditions.
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