Epigenetic Regulation of Autophagy in Bone Metabolism.

IF 5.1 Q2 CELL BIOLOGY Function (Oxford, England) Pub Date : 2024-01-27 eCollection Date: 2024-01-01 DOI:10.1093/function/zqae004
Yazhou Zhang, Qianqian Wang, Hongjia Xue, Yujin Guo, Shanshan Wei, Fengfeng Li, Linqiang Gong, Weiliang Pan, Pei Jiang
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Abstract

The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects such as bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy's impact on bone health varies depending on factors such as regulation, cell type, environmental cues, and physiological context. Despite being traditionally considered a cytoplasmic process, autophagy is subject to transcriptional and epigenetic regulation within the nucleus. However, the precise influence of epigenetic regulation, including DNA methylation, histone modifications, and non-coding RNA expression, on cellular fate remains incompletely understood. The interplay between autophagy and epigenetic modifications adds complexity to bone cell regulation. This article provides an in-depth exploration of the intricate interplay between these two regulatory paradigms, with a focus on the epigenetic control of autophagy in bone metabolism. Such an understanding enhances our knowledge of bone metabolism-related disorders and offers insights for the development of targeted therapeutic strategies.

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骨代谢中自噬的表观遗传调控
骨骼系统对于支持身体机能、保护重要器官、促进造血和储存必需矿物质至关重要。骨骼平衡包括骨密度、结构完整性和再生过程等方面,对骨骼功能的正常发挥至关重要。自噬是一种降解和回收细胞成分的复杂细胞内机制,在骨代谢中发挥着多方面的作用。它将细胞废物、受损蛋白质和细胞器封存在自噬体中,然后进行降解和再循环。自噬对骨骼健康的影响因调节、细胞类型、环境线索和生理背景等因素而异。尽管自噬传统上被认为是一个细胞质过程,但它在细胞核内受到转录和表观遗传的调控。然而,表观遗传调控(包括 DNA 甲基化、组蛋白修饰和非编码 RNA 表达)对细胞命运的确切影响仍不完全清楚。自噬和表观遗传修饰之间的相互作用增加了骨细胞调控的复杂性。本文深入探讨了这两种调控模式之间错综复杂的相互作用,重点是自噬在骨代谢中的表观遗传调控。这种认识增强了我们对骨代谢相关疾病的了解,并为开发有针对性的治疗策略提供了启示。
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来源期刊
CiteScore
5.70
自引率
0.00%
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0
审稿时长
3 weeks
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