Curcumin as a regulator of Th17 cells: Unveiling the mechanisms

IF 4.1 Q2 FOOD SCIENCE & TECHNOLOGY Food Chemistry Molecular Sciences Pub Date : 2024-03-12 DOI:10.1016/j.fochms.2024.100198

Ehsan Ghoushi , Mohadeseh Poudineh , Negin Parsamanesh , Tannaz Jamialahmadi , Amirhossein Sahebkar

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Abstract

Curcumin, a polyphenol natural product derived from turmeric, possesses diverse pharmacological effects due to its interactions with various cells and molecules. Recent studies have highlighted its immunomodulatory properties, including its impact on immune cells and mediators involved in immune responses. Th17 cells play a crucial role in promoting immune responses against extracellular pathogens by recruiting neutrophils and inducing inflammation. These cells produce inflammatory cytokines such as TNF-α, IL-21, IL-17A, IL-23, IL-17F, IL-22, and IL-26. Curcumin has been shown to significantly inhibit the proliferation of Th17 cells and reduce the production of inflammatory cytokines, including TNF-α, IL-22, and IL-17. This review aims to assess the effectiveness of curcumin and its underlying mechanisms in modulating Th17 cells.

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姜黄素是 Th17 细胞的调节剂：揭示机制

姜黄素是一种从姜黄中提取的多酚天然产物，它与各种细胞和分子相互作用，具有多种药理作用。最近的研究强调了姜黄素的免疫调节特性，包括它对免疫细胞和参与免疫反应的介质的影响。Th17 细胞通过招募中性粒细胞和诱导炎症，在促进针对细胞外病原体的免疫反应中发挥着至关重要的作用。这些细胞会产生炎性细胞因子，如 TNF-α、IL-21、IL-17A、IL-23、IL-17F、IL-22 和 IL-26。姜黄素能显著抑制 Th17 细胞的增殖，并减少 TNF-α、IL-22 和 IL-17 等炎性细胞因子的产生。本综述旨在评估姜黄素在调节 Th17 细胞方面的功效及其内在机制。

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