Exploring the role of NAA40 in immune infiltrates and prognostic prediction in hepatocellular carcinoma.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-02-25 eCollection Date: 2024-01-01
Tong Zhou, Jun Cao, Qingqin Tang, Jieyu Jin, Yuting Liang, Bin Feng
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Abstract

NAA40 belongs to the N-terminal acetyltransferase (NATs) family, responsible for protein N-terminal modification, and it exerts crucial roles across various cancers. However, its impact on patient prognosis and immune infiltration in hepatocellular carcinoma (HCC) remains elusive. To address this, our study delved into the comprehensive analysis of NAA40 in the context of cancer. Our pan-cancer analysis unveiled elevated NAA40 expression in multiple tumor types, including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, LIHC, LUAD, LUSC, STAD, and THCA. Additionally, through a comprehensive examination across various cancer types within TCGA, we discovered that high NAA40 gene expression correlated with poor prognosis in HCC, pointing toward its role in promoting oncogenesis. Further investigation illuminated the association of increased NAA40 expression with T stage, pathologic stage, tumor status, and histologic grade. Interestingly, we noted a significant inverse correlation between NAA40 expression and the infiltration levels of immune cells, such as DC cells, neutrophils, NK cells, and T cells, in liver cancer. This observation underpins the hypothesis that NAA40 influences HCC development by modulating immune cell infiltration. Functional enrichment analysis provided valuable insights into the pathways influenced by NAA40. Enriched pathways encompassed oxidative phosphorylation, xenobiotic metabolism, bile acid metabolism, fatty acid metabolism, G2M checkpoint, and E2F targets. These findings collectively position NAA40 as a potential biomarker for prognostic prediction and monitoring the effects of immunotherapy in HCC.

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探索 NAA40 在肝细胞癌免疫浸润和预后预测中的作用。
NAA40属于N端乙酰转移酶(NATs)家族,负责蛋白质的N端修饰,在各种癌症中发挥着重要作用。然而,它对肝细胞癌(HCC)患者预后和免疫浸润的影响仍然难以捉摸。为了解决这个问题,我们的研究深入研究了癌症背景下 NAA40 的全面分析。我们的泛癌症分析揭示了NAA40在多种肿瘤类型中的高表达,包括BLCA、BRCA、CHOL、COAD、ESCA、HNSC、LIHC、LUAD、LUSC、STAD和THCA。此外,通过对TCGA中各种癌症类型的全面检查,我们发现NAA40基因的高表达与HCC的不良预后相关,这表明NAA40在促进肿瘤发生中的作用。进一步的研究表明,NAA40表达的增加与T分期、病理分期、肿瘤状态和组织学分级有关。有趣的是,我们注意到NAA40的表达与肝癌中免疫细胞(如DC细胞、中性粒细胞、NK细胞和T细胞)的浸润水平呈显著的反相关。这一观察结果支持了NAA40通过调节免疫细胞浸润影响HCC发展的假设。功能富集分析为了解受NAA40影响的通路提供了宝贵的信息。富集途径包括氧化磷酸化、异生物代谢、胆汁酸代谢、脂肪酸代谢、G2M检查点和E2F靶点。这些发现共同将NAA40定位为一种潜在的生物标记物,用于预测HCC的预后和监测免疫疗法的效果。
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