Investigating the role of salivary Interleukin-40 levels in diagnosing periodontal diseases.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-03-21 DOI:10.1111/odi.14936

Fatma Köksel Babun, Nezahat Arzu Kayar, Mükerrem Hatipoğlu

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Abstract

Background: The present study aimed to analyze IL-40, IL-1β, and MMP-8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters.

Materials and methods: We collected saliva samples from 120 systemically healthy, non-smoking individuals aged between 18 and 63 years. These individuals were divided into three groups: healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]. IL-40, IL-1β, and MMP-8 levels in saliva samples were analyzed by ELISA.

Results: We observed significantly elevated salivary IL-40 levels in the G group compared to the S group (p = 0.003). We found significantly higher salivary IL-1β levels in the P group compared to both the S and G groups (p = 0.000). Salivary MMP-8 levels were significantly higher in the P group than in the S group (p = 0.016).

Conclusion: Our study suggests that IL-40 and IL-1β may serve as effective salivary biomarkers for diagnosing gingivitis, while MMP-8 and IL-1β may be effective for distinguishing periodontitis. Based on our study's findings, it can be stated that IL-40 may serve as a new and effective biomarker for distinguishing individuals with gingivitis from healthy ones.

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研究唾液白细胞介素-40 水平在诊断牙周疾病中的作用。

研究背景本研究旨在分析牙周炎以及牙龈炎和牙周健康中的IL-40、IL-1β和MMP-8水平，并探讨这些生物标志物与标准临床参数之间的潜在相关性：我们收集了 120 名全身健康、不吸烟、年龄在 18 岁至 63 岁之间的人的唾液样本。这些人被分为三组：健康对照组[S]、牙龈炎组[G]和 III 期 B 级牙周炎组[P]。采用 ELISA 方法分析唾液样本中的 IL-40、IL-1β 和 MMP-8 水平：结果：与 S 组相比，我们发现 G 组唾液中的 IL-40 水平明显升高（p = 0.003）。我们发现，与 S 组和 G 组相比，P 组唾液 IL-1β 水平明显升高（p = 0.000）。P 组唾液 MMP-8 水平明显高于 S 组（p = 0.016）：我们的研究表明，IL-40 和 IL-1β 可作为诊断牙龈炎的有效唾液生物标志物，而 MMP-8 和 IL-1β 可作为鉴别牙周炎的有效唾液生物标志物。根据我们的研究结果，IL-40 可以作为一种新的、有效的生物标记物来区分牙龈炎患者和健康患者。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.