Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-03-22 DOI:10.1016/j.ijheh.2024.114359

Megan E. Romano , Lisa G. Gallagher , George Price , Kathryn A. Crawford , Rachel Criswell , Emily Baker , Julianne Cook Botelho , Antonia M. Calafat , Margaret R. Karagas

{"title":"Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study","authors":"Megan E. Romano , Lisa G. Gallagher , George Price , Kathryn A. Crawford , Rachel Criswell , Emily Baker , Julianne Cook Botelho , Antonia M. Calafat , Margaret R. Karagas","doi":"10.1016/j.ijheh.2024.114359","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Prior studies suggest that prenatal per- and polyfluoroalkyl substances (PFAS) exposures are associated with shorter breastfeeding duration. Studies assessing PFAS mixtures and populations in North America are sparse.</p></div><div><h3>Methods</h3><p>We quantified PFAS concentrations in maternal plasma collected during pregnancy in the New Hampshire Birth Cohort Study (2010–2017). Participants completed standardized breastfeeding surveys at regular intervals until weaning (n = 813). We estimated associations between mixtures of 5 PFAS and risk of stopping exclusive breastfeeding before 6 months or any breastfeeding before 12 months using probit Bayesian kernel machine regression. For individual PFAS, we calculated the relative risk and hazard ratio (HR) of stopping breastfeeding using modified Poisson regression and accelerated failure time models respectively.</p></div><div><h3>Results</h3><p>PFAS mixtures were associated with stopping exclusive breastfeeding before 6 months, primarily driven by perfluorooctanoate (PFOA). We observed statistically significant trends in the association of perfluorohexane sulfonate (PFHxS), PFOA, and perfluorononanoate (PFNA) (p-trends≤0.02) with stopping exclusive breastfeeding. Participants in the highest PFOA quartile had a 28% higher risk of stopping exclusive breastfeeding before 6 months compared to those in the lowest quartile (95% Confidence Interval: 1.04, 1.56). Similar trends were observed for PFHxS and PFNA with exclusive breastfeeding (p-trends≤0.05). PFAS were not associated with stopping any breastfeeding before 12 months.</p></div><div><h3>Conclusions</h3><p>In this cohort, we observed that participants with greater overall plasma PFAS concentrations had greater risk of stopping exclusive breastfeeding before 6 months and associations were driven largely by PFOA. These findings further support the growing literature indicating that PFAS may be associated with shorter duration of breastfeeding.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"258 ","pages":"Article 114359"},"PeriodicalIF":4.5000,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hygiene and environmental health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1438463924000403","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Prior studies suggest that prenatal per- and polyfluoroalkyl substances (PFAS) exposures are associated with shorter breastfeeding duration. Studies assessing PFAS mixtures and populations in North America are sparse.

Methods

We quantified PFAS concentrations in maternal plasma collected during pregnancy in the New Hampshire Birth Cohort Study (2010–2017). Participants completed standardized breastfeeding surveys at regular intervals until weaning (n = 813). We estimated associations between mixtures of 5 PFAS and risk of stopping exclusive breastfeeding before 6 months or any breastfeeding before 12 months using probit Bayesian kernel machine regression. For individual PFAS, we calculated the relative risk and hazard ratio (HR) of stopping breastfeeding using modified Poisson regression and accelerated failure time models respectively.

Results

PFAS mixtures were associated with stopping exclusive breastfeeding before 6 months, primarily driven by perfluorooctanoate (PFOA). We observed statistically significant trends in the association of perfluorohexane sulfonate (PFHxS), PFOA, and perfluorononanoate (PFNA) (p-trends≤0.02) with stopping exclusive breastfeeding. Participants in the highest PFOA quartile had a 28% higher risk of stopping exclusive breastfeeding before 6 months compared to those in the lowest quartile (95% Confidence Interval: 1.04, 1.56). Similar trends were observed for PFHxS and PFNA with exclusive breastfeeding (p-trends≤0.05). PFAS were not associated with stopping any breastfeeding before 12 months.

Conclusions

In this cohort, we observed that participants with greater overall plasma PFAS concentrations had greater risk of stopping exclusive breastfeeding before 6 months and associations were driven largely by PFOA. These findings further support the growing literature indicating that PFAS may be associated with shorter duration of breastfeeding.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

新罕布什尔州出生队列研究中孕期血浆中的全氟和多氟烷基物质混合物与母乳喂养时间的关系

背景先前的研究表明，产前接触全氟烷基和多氟烷基物质（PFAS）与母乳喂养时间缩短有关。我们在新罕布什尔州出生队列研究（2010-2017 年）中对孕期收集的母体血浆中的 PFAS 浓度进行了量化。参与者定期完成标准化母乳喂养调查，直至断奶（n = 813）。我们使用 probit Bayesian 核机器回归法估算了 5 种 PFAS 混合物与 6 个月前停止纯母乳喂养或 12 个月前停止任何母乳喂养的风险之间的关系。对于单个 PFAS，我们分别使用修正泊松回归和加速失败时间模型计算了停止母乳喂养的相对风险和危险比 (HR)。我们观察到，全氟己烷磺酸（PFHxS）、全氟辛酸（PFOA）和全氟壬酸（PFNA）与停止纯母乳喂养之间存在具有统计学意义的关联趋势（p-趋势≤0.02）。与最低四分位数的参与者相比，PFOA最高四分位数的参与者在6个月前停止纯母乳喂养的风险高出28%（95%置信区间：1.04, 1.56）。全氟己烷磺酸（PFHxS）和全氟萘胺（PFNA）与纯母乳喂养也有类似的趋势（P-趋势≤0.05）。结论在这个队列中，我们观察到血浆中全氟辛烷磺酸总体浓度较高的参与者在 6 个月前停止纯母乳喂养的风险更大，而这种关联主要是由全氟辛酸引起的。这些发现进一步证实了越来越多的文献表明 PFAS 可能与缩短母乳喂养时间有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

International journal of hygiene and environmental health 医学-传染病学

CiteScore

11.50

自引率

5.00%

发文量

151

审稿时长

22 days

期刊介绍： The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.