Apoptotic Effects of Adipose-Derived Stem Cell Secretome in Breast Cancer Stem Cells: A Literature Review

Abstract

Adipose-derived stem cells (ASC) are cells from the core of fat tissue that secrete various cytokines, growth factors, proteins and extracellular vesicles that can be used in regenerative therapy, especially in the case of cancer. This ASC produces a secretome which is an exosome derived from ASC. In many studies it has been proven that the secretome has proangiogenic, neurotrophic and epithelialization activities and has the potential to be used for cardiovascular, respiratory, neurodegenerative, inflammatory and autoimmune diseases, as a wound healing treatment and as an immunomodulator in anticancer therapy through induction of apoptosis. Due to the limited use of stem cells in cell-based therapies, secretomes from ACS-derived exosomes may be a safer alternative treatment in the future with higher levels of effectiveness and lower side effects. Therefore in this review, we focus on the current knowledge about the ASC secretome that can induce breast cancer cell apoptosis.